Novel berberine derivative as well as synthesis method and application thereof

A technology of berberine and its derivatives, applied in the direction of organic chemical methods, chemical instruments and methods, isotope introduction into organic compounds, etc., can solve the problems of difficult synthesis of raw materials, difficult clinical transformation, low yield, etc., to achieve clinical transformation , Raw materials are easy to get, and the effect of reducing costs
CN112250680AActive Publication Date: 2021-01-22WEST CHINA HOSPITAL SICHUAN UNIV
7 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-01-22

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a novel berberine derivative as well as a synthesis method and application thereof, belongs to the field of imaging agents, and aims to derive the structure of isoquinoline alkaloid berberine, optimize derived sites on the basis of an early stage and introduce an F-containing side chain to prepare a series of probes with a myocardial targeting property. A 18F marker of theseries of compounds is successfully prepared through a marking experiment of positron nuclide 18F; the 18F-labeled novel berberine derivative is higher in myocardial uptake, raw materials are easy toobtain, the synthesis cost of a molecular probe is reduced, and clinical transformation is facilitated.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of imaging agents, and in particular relates to a novel berberine derivative and its synthesis method and application. Background technique

[0002] Although the diagnosis and treatment of coronary heart disease have made great progress in recent years, coronary heart disease is still one of the major diseases that seriously threaten human health worldwide (especially in European and American countries). In my country, the incidence and mortality of coronary heart disease and heart-related diseases are also on the rise. According to the latest data from the World Health Organization (WHO), my country will usher in the peak of cardiovascular diseases in the next five years or so. Therefore, early diagnosis, early intervention and prognosis evaluation of coronary heart disease and other heart-related diseases are particularly important.

[0003] As a non-invasive diagnostic technique, myocardial perfusion imaging is pa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More