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Application of retegravir in preparation of medicine for treating idiopathic pulmonary fibrosis

A pulmonary fibrosis, idiopathic technology, applied in the field of biomedicine, can solve the problem of pulmonary fibrosis without Remdesivir

Inactive Publication Date: 2021-01-29
TIANJIN JIKUN MEDICAL TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Remdesivir has a certain inhibitory effect on filoviruses, arenaviruses, and coronaviruses, but so far, there are no reports that remdesivir can slow down or treat pulmonary fibrosis caused by non-coronaviruses, and there are no reports of remdesivir Relevant reports that decivir can slow down and treat idiopathic pulmonary fibrosis

Method used

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  • Application of retegravir in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of retegravir in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of retegravir in preparation of medicine for treating idiopathic pulmonary fibrosis

Examples

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Embodiment 1

[0034] Example 1: Remdesivir slows down idiopathic pulmonary fibrosis

[0035] 1. Animal model preparation: The idiopathic pneumonia model using bleomycin is currently the most used idiopathic pulmonary fibrosis model. Male C57BL / 6J wild-type mice (8-10 weeks old) were anesthetized by intraperitoneal injection of 0.5ml / 100g (body weight) with a mass volume concentration of 10% chloral hydrate, and intratracheal invasive injection of 2U / kg bleomycin. The specific implementation method is as follows: after the mouse is anesthetized, weigh and record, fix the mouse on the operating table, disinfect the neck with 70% alcohol, use a scalpel to make a vertical wound of about 1 cm in the neck of the mouse, and use micro tweezers to separate The tissue exposed the trachea, and the syringe was pierced into the trachea through the gap between the tracheal cartilage rings toward the heart, and then slowly injected with a volume of bleomycin saline solution corresponding to its body wei...

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Abstract

The embodiment of the invention relates to an application of retegravir in preparation of a medicine for treating idiopathic pulmonary fibrosis. The retegravir has a good effect on idiopathic pulmonary fibrosis, has no adverse reaction, and can improve the vital capacity, inspiration airway resistance, expiration airway resistance and dynamic compliance of a patient suffering from idiopathic pulmonary fibrosis; the lung collagen content of patients with idiopathic pulmonary fibrosis is reduced; and the pulmonary fibrosis area is reduced or the pulmonary fibrosis area is prevented from being increased.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of remdesivir in the preparation of drugs for treating idiopathic pulmonary fibrosis. Background technique [0002] With the aggravation of environmental pollution, the incidence of lung diseases continues to rise. Pulmonary fibrosis (PF) is characterized by persistent damage to the alveoli, proliferation of fibroblasts, and deposition of a large amount of extracellular matrix (ECM), resulting in varying degrees of inflammation and fibrosis in the alveoli and interstitium. A disease that causes destruction of lung structure and respiratory failure, so it is also called interstitial lung disease (ILD) or diffuse parenchymal lung disease (DPLD). [0003] The etiology of pulmonary fibrosis includes physical factors, chemical factors, biological factors, etc., and also includes pulmonary fibrosis of unknown etiology, such as idiopathic pulmonary fibrosis. Idiopathic pulmo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61P11/00
CPCA61K31/685A61P11/00
Inventor 杨诚周红刚李霄鹤
Owner TIANJIN JIKUN MEDICAL TECH CO LTD
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