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Application of avitinib in preparation of medicine for treating idiopathic pulmonary fibrosis

A pulmonary fibrosis and avitinib technology, applied in the field of biomedicine, can solve the problems of poor treatment response, incomplete elucidation of the pharmacological mechanism, and inability to reverse the progression of the disease, achieve good application prospects and reduce pulmonary fibrosis. area, the effect of improving lung capacity

Inactive Publication Date: 2021-04-20
TIANJIN JIKUN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although these drugs can delay the rate of decline in lung function, they cannot reverse the progression of the disease, and a considerable number of patients respond poorly to treatment, and the specific pharmacological mechanism has not yet been fully elucidated

Method used

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  • Application of avitinib in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of avitinib in preparation of medicine for treating idiopathic pulmonary fibrosis
  • Application of avitinib in preparation of medicine for treating idiopathic pulmonary fibrosis

Examples

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Embodiment 1

[0028]Example 1: Avitinib slows down idiopathic pulmonary fibrosis

[0029] 1. Animal model preparation: The idiopathic pneumonia model using bleomycin is currently the most used idiopathic pulmonary fibrosis model. Male C57BL / 6J wild-type mice (8-10 weeks old) were anesthetized by intraperitoneal injection of 0.5ml / 100g (body weight) with a mass volume concentration of 10% chloral hydrate, and intratracheal invasive injection of 2U / kg bleomycin. The specific implementation method is as follows: after the mouse is anesthetized, weigh and record, fix the mouse on the operating table, disinfect the neck with 70% alcohol, use a scalpel to make a vertical wound of about 1 cm in the neck of the mouse, and use micro tweezers to separate The tissue exposed the trachea, and the syringe was pierced into the trachea through the gap between the tracheal cartilage rings toward the heart, and then slowly injected with a volume of bleomycin saline solution corresponding to its body weight...

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Abstract

The invention provides application of avitinib in preparation of a medicine for treating idiopathic pulmonary fibrosis. The avitinib or the pharmaceutically acceptable salts, esters and hydrates thereof have good effects on idiopathic pulmonary fibrosis, have no adverse reaction, and can improve the forced vital capacity, inspiration airway resistance, expiration airway resistance and dynamic compliance of patients with idiopathic pulmonary fibrosis; the lung collagen content of the patients with idiopathic pulmonary fibrosis is reduced; the pulmonary fibrosis area is reduced or the increase of the pulmonary fibrosis area is prevented; and good application prospects are provided for treating, relieving or improving pulmonary fibrosis diseases.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of avitinib in the preparation of medicines for treating idiopathic pulmonary fibrosis. Background technique [0002] With the aggravation of environmental pollution, the incidence of lung diseases continues to rise. Pulmonary fibrosis (PF) is characterized by persistent damage to the alveoli, proliferation of fibroblasts, and deposition of a large amount of extracellular matrix (ECM), resulting in varying degrees of inflammation and fibrosis in the alveoli and interstitium. A disease that causes destruction of lung structure and respiratory failure, so it is also called interstitial lung disease (ILD) or diffuse parenchymal lung disease (DPLD). [0003] The etiology of pulmonary fibrosis includes physical factors, chemical factors, biological factors, etc., and also includes pulmonary fibrosis of unknown etiology, such as idiopathic pulmonary fibrosis. Idiopathic pul...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P11/00
Inventor 杨诚周红刚李霄鹤张亮李建伦东超
Owner TIANJIN JIKUN MEDICAL TECH CO LTD
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