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Myricetin functionalized silver nanoparticles, green preparation method thereof and pharmaceutical composition

A functional and compositional technology, applied in the direction of drug combination, drug delivery, antibacterial drugs, etc., can solve the problem of decreased bactericidal effect, and achieve the effect of simple operation, good antibacterial and antioxidant activity, and obvious antibacterial activity

Inactive Publication Date: 2021-02-12
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, relevant reports in the prior art indicate that the bactericidal effect of myricetin combined with nanomaterials has declined

Method used

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  • Myricetin functionalized silver nanoparticles, green preparation method thereof and pharmaceutical composition
  • Myricetin functionalized silver nanoparticles, green preparation method thereof and pharmaceutical composition
  • Myricetin functionalized silver nanoparticles, green preparation method thereof and pharmaceutical composition

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preparation example Construction

[0064] The second aspect of the present invention provides the preparation method of the myricetin functionalized nano-silver particles described in the first aspect, the preparation method comprising the following steps: adding the silver nitrate solution to the organic solution of myricetin and heating and mixing until the color of the solution changes to After the grass turns green, continue heating to obtain the nano-silver particles.

[0065] Preferably, the organic solution of myricetin is one of methanol, ethanol and acetonitrile solutions including but not limited to myricetin.

[0066] In the above scheme, the ethanol solution of myricetin is preferably used, which is less toxic than other reagents, and the prepared silver nanoparticles are safer.

[0067] Furthermore, the preparation method uses ethanol solution of myricetin, and the configuration ratio is as follows: 30-40 mg of myricetin is mixed with 40-60 ml of 45-55% ethanol solution.

[0068] Preferably, the h...

Embodiment 1

[0085] 1. Synthesis of silver nanoparticles

[0086] A standard sample of myricetin (39 mg) was accurately weighed and dissolved in 50 ml of 50% ethanol, and silver nitrate was dissolved in deionized water. Then add 8mL myricetin ethanol solution in 25mL round bottom flask, add 2mL silver nitrate solution in it, make MY:AgNO 3 (1:1) final molar ratio. The mixture was heated on an oil bath at a set temperature (50°C). A color change occurred at 15 minutes, gradually turning grass green, and black particles could be seen suspended in solution. At this time, the nano-silver particles are initially formed. After heating for 3 hours, the reaction mixture was poured into a centrifuge tube. After centrifuging at 8000 rpm for 30 minutes, the supernatant was taken, and the supernatant was reserved for measurement by an inductively coupled plasma spectrometer (ICP). Rinse 2-3 times with deionized water to remove excess organic matter. After drying, the nano-silver particles are ev...

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Abstract

The invention particularly relates to myricetin functionalized silver nanoparticles, a green preparation method thereof and a pharmaceutical composition. Myricetin has various biological characteristics of antibiosis, antioxidation, anticancer and the like, but is poor in water solubility, so bioavailability is low. The invention provides a myricetin-mediated silver nanoparticle. The silver nanoparticle has good oxidation resistance, and the free radical scavenging rate of the silver nanoparticle is about 60-87% under different concentrations (0.01-0.1 mg / ml). The biosynthesized nano-silver particles have good antibacterial performance on escherichia coli and salmonella at room temperature. The minimum inhibitory concentrations (MIC) are 10<-4> g / L and 10<-5> g / L respectively.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a myricetin-functionalized nano-silver particle, a preparation method of the nano-silver particle, a pharmaceutical composition containing the nano-silver particle, an antibacterial preparation and an antioxidant preparation. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, many natural products have shown good antibacterial and antiviral properties, including flavonoids, alkaloids, organic acids, volatile oils, polysaccharides, saponins, anthraquinones, terpenoids, etc. Among them, flavonoids are an important class of natural organ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K47/69A61K47/55A61K31/352A61K33/38A61P31/04A61P39/06
CPCA61K45/06A61K47/6923A61K47/55A61K31/352A61K33/38A61P31/04A61P39/06A61K2300/00Y02A50/30
Inventor 王岱杰李兆崔莉施树云郭莹林树乾李戈宋祥云李景超
Owner SHANDONG ANALYSIS & TEST CENT
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