Myricetin functionalized silver nanoparticles, green preparation method thereof and pharmaceutical composition

A functional and compositional technology, applied in the direction of drug combination, drug delivery, antibacterial drugs, etc., can solve the problem of decreased bactericidal effect, and achieve the effect of simple operation, good antibacterial and antioxidant activity, and obvious antibacterial activity
CN112353945AInactive Publication Date: 2021-02-12SHANDONG ANALYSIS & TEST CENT
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG ANALYSIS & TEST CENT
Publication Date
2021-02-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention particularly relates to myricetin functionalized silver nanoparticles, a green preparation method thereof and a pharmaceutical composition. Myricetin has various biological characteristics of antibiosis, antioxidation, anticancer and the like, but is poor in water solubility, so bioavailability is low. The invention provides a myricetin-mediated silver nanoparticle. The silver nanoparticle has good oxidation resistance, and the free radical scavenging rate of the silver nanoparticle is about 60-87% under different concentrations (0.01-0.1 mg / ml). The biosynthesized nano-silver particles have good antibacterial performance on escherichia coli and salmonella at room temperature. The minimum inhibitory concentrations (MIC) are 10<-4> g / L and 10<-5> g / L respectively.
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Description

technical field

[0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a myricetin-functionalized nano-silver particle, a preparation method of the nano-silver particle, a pharmaceutical composition containing the nano-silver particle, an antibacterial preparation and an antioxidant preparation. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] In recent years, many natural products have shown good antibacterial and antiviral properties, including flavonoids, alkaloids, organic acids, volatile oils, polysaccharides, saponins, anthraquinones, terpenoids, etc. Among them, flavonoids are an important class of natural organ...

Claims

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