Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener

Abstract

In certain embodiments, the present disclosure is directed to methods and uses for treating seizure disorders in a human, wherein the methods and uses comprise orally administering a therapeutically effective amount of the voltage-gated potassium channel allosteric modulator, N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3- dimethylbutanamide (Compound A), to the human in need thereof, for example, under fed conditions. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.

Description

[0001]1. Background technology[0002]Epilepsy is a common neurological disease. The estimated prevalence worldwide is 0.7% of the population (50 million people) (see Hirtz, D. et al. "Neurology. (2007), 68: 326- 337). It is characterized by abnormal electrical activity in the brain that causes seizures. For epidemiological purposes, this definition requires more than one unprovoked seizure of any type.[0003]Mainly due to the etiology of the disease, compared with the general population, patients with epilepsy have an increased risk of death. However, among patients with uncontrollable epilepsy, the highest risk of seizure-related death is due to sudden epilepsy death (SUDEP) (see Hitiris, N. et al., Epilepsy and Behavior (2007), 10. :363-376. Patients participating in clinical trials of investigational anti-epileptic drugs (AED) usually have epilepsy for more than 10 years, and multiple AED treatments are ineffective.[0004]The pathophysiology of most forms of epilepsy is still poorly...

AI Technical Summary

Problems solved by technology

Although neuronal potassium-gated channels play a major role in controlling neuronal excitability, current drugs have little effect on these channels

Therefore, drugs with novel mechanisms of action or improvements to already marketed AEDs are needed to address a meaningful unmet clinical need for seizure control in patients with refractory epilepsy

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