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Anti-anxiety/anti-depression medicinal composition and application thereof

A composition and anti-depressant technology, which is applied in the direction of drug combination, effective ingredients of hydroxyl compounds, and pharmaceutical formulations, can solve the problems of anti-anxiety/anti-depressant drug adverse reactions and poor effects, and achieve dosage reduction, cost reduction, and safety good sex effect

Active Publication Date: 2021-02-23
HEMPIRE (SHANGHAI) PHARM R&D LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to solve the problem of serious adverse reactions or poor effects of existing anti-anxiety / anti-depressant drugs, and to provide a pharmaceutical composition. Act synergistically with significant antidepressant and / or anxiolytic effects

Method used

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  • Anti-anxiety/anti-depression medicinal composition and application thereof
  • Anti-anxiety/anti-depression medicinal composition and application thereof
  • Anti-anxiety/anti-depression medicinal composition and application thereof

Examples

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preparation example Construction

[0037] Preparation of the refined cannabis extract of the test drug: take industrial hemp flowers and leaves, extract them with ethanol, and molecularly distill the cannabis extract, then collect cannabidiol, tetrahydrocannabinol, and cannabinol in sections through high-pressure preparation chromatography, and then three The main ingredients are crystallized to prepare pure products, namely CBD (99.84%), THC (99.32%) and CBN (99.02%).

[0038] 2.1.1 Preparation of test liquid:

[0039] Preparation of CBD sub-microemulsion: Weigh 25g of glycerin and dissolve it in 500ml of water for injection, weigh 12g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.0943g of CBD crystals and dissolve it in 100g In coconut oil, add 2g of oleic acid and mix well to obtain a CBD oil solution; add the CBD oil solution into a high-shear emulsifier at a constant speed to prepare a fat emulsion solution, and ...

Embodiment 1-3 and comparative example 1-4

[0064] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.3765g of CBD crystals, 0.0063g of THC crystals, and 0.0126g of CBN crystals Dissolve in 1000g (300g sweet almond oil, 300g coconut oil, 400g linseed oil) mixed oil, add 20g oleic acid and mix well to obtain an oil phase; add the oil phase to a high shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution of Example 2, the content of CBD is 0.03759mg / ml, THC The content of CBN is 0.00063mg / ml, and the content of CBN is 0.00125mg / ml (the ratio is about 60:1:2); according to this method, other examples and comparative examples are prepared acc...

Embodiment 4-6 and comparative example 5-8

[0104] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.3765g of CBD crystals, 0.0063g of THC crystals, and 0.0126g of CBN crystals Dissolve in 1000g (300g sweet almond oil, 300g coconut oil, 400g linseed oil) mixed oil, add 20g oleic acid and mix well to obtain an oil phase; add the oil phase to a high shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution in Example 5, the content of CBD is 0.03759mg / ml, THC The content of CBN is 0.00063 mg / ml, and the content of CBN is 0.00125 mg / ml (the ratio is about 60:1:2); according to this method, the test liquids of other examples and comparative exa...

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Abstract

The invention discloses an anti-anxiety / anti-depression medicinal composition and an application thereof. Active components of the medicinal composition comprise the following components in parts by weight: 40-80 parts of cannabidiol, 0.5-1.5 parts of tetrahydrocannabinol and 1.3-2.7 parts of cannabinol. According to the medicinal composition provided by the invention, cannabis sativa extracts arecombined in different proportions, the effects of resisting anxiety, resisting depression, relieving spirit and the like are achieved through the interaction of the medicinal components, the dosage of the cannabis sativa extracts, particularly the cannabidiol, can be greatly reduced, and the medicinal composition is particularly suitable for various crowds under the current social pressure.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anxiolytic / antidepressant pharmaceutical composition and its application. Background technique [0002] At present, with the acceleration of the pace of life, the increase of life pressure, the number of people living alone is increasing, and the people with sleep disorders, anxiety and depression are developing from middle-aged and elderly people to younger people. People are also paying more and more attention to the impact of sub-health status on quality of life. Depressed and depressed people are the main force in sub-healthy people. [0003] Anxiety and depression are a kind of mental illness that endanger people's healthy life. At present, my country's economy is developing rapidly, social competition is fierce, and the urban population is increasing rapidly. The number of patients with anxiety and depression has increased significantly. At present, the commonly used anti...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/05A61P25/22A61P25/24
CPCA61K31/05A61K31/352A61P25/22A61P25/24A61K2300/00
Inventor 邹陈东肖挽李国辉黄穗
Owner HEMPIRE (SHANGHAI) PHARM R&D LTD
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