Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate

A technology of sodium lauryl sulfate and pharmaceutical excipients, which is applied to the preparation of sulfate esters, the preparation of organic compounds, chemical instruments and methods, etc. It can solve the problems of poor stability of pH value and affect product stability, and achieve stable good sex effect

Pending Publication Date: 2021-03-16
江苏优扬药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the stabilizers with good pH value of 7.5-9.5 include phosphate (including phosphate, polymeric phosphate, etc.), carbonate series, etc., while sulfate, citrate, and EDTA salt have poor pH stabilization effects
However, the addition of these inorganic salts will lead to the reaction of calcium, aluminum, and magnesium ions in the pharmaceutical production process to form precipitates, which will affect the stability of the product.

Method used

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  • Preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Such as figure 1 Shown, a kind of preparation device of sodium lauryl sulfate of medicinal adjuvant: comprise sulfonation reactor 5, neutralizer 6, homogenization tank 7, feeder 8, quantitative feeder 9, drier 10, Cyclone filter 11, milling system 13, secondary dryer 14 and powder homogenizer 15;

[0028] The top of the sulfonation reactor 5 is provided with SO 3 A sulfonating agent feed port 1 and a dodecyl alcohol feed port 2, the bottom is provided with an acid ester discharge port; the acid acid discharge port is connected to the feed port of the neutralizer 6;

[0029] The neutralizer 6 is provided with an alkali feed port 3, wherein a liquid caustic neutralizing agent is passed into;

[0030] The outlet of the neutralizer 6 is connected to the inlet of the homogenizing tank 7, and the bottom outlet of the homogenizing tank is connected to the feeder 8, and the feeder 8 is connected to the drier 10;

[0031] The outlet of the drier 10 and the discharge port of t...

Embodiment 2

[0041] A preparation method of sodium lauryl sulfate as a pharmaceutical auxiliary material, characterized in that the steps are as follows:

[0042] (1) Control of sulfonation reaction degree: 105g dodecanol and 41.3g SO 3 The sulfonation reaction generates 146.3 g of lauryl sulfate, and the conversion rate is 95.0%;

[0043] (2) Neutralizing and high pH value control: 65.2g of sodium lauryl sulfate from the reaction of sulfonated lauryl sulfate and 32% sodium hydroxide is produced, and the pH value is controlled at 10.5;

[0044] (3) Drying and adjusting the pH value of the powder: Dehydrate and dry the neutralized material to obtain 162.4g, add 1.1g of solid organic acid regulator, and send it to the milling system for grinding and homogenizing, the pH value of the powder is 7.6 ;

[0045] (4) Dealcoholization: Use hot air to reduce the partial pressure of fatty alcohol to remove most of the volatile dodecanol from the ground material, and use the fat recovery system to r...

Embodiment 3

[0048] A preparation method of sodium lauryl sulfate as a pharmaceutical auxiliary material, characterized in that the steps are as follows:

[0049] (1) Control of sulfonation reaction degree: 103g dodecanol and 41.3g SO 3 Sulfonation reaction generates lauryl sulfate 144.3g, conversion rate 97.0%;

[0050] (2) Neutralizing and high pH value control: 65.2g of sodium lauryl sulfate from the reaction of sulfonated lauryl sulfate and 32% sodium hydroxide is produced, and the pH value is controlled at 10.3;

[0051] (3) Drying and adjusting the pH value of the powder: Dehydrate and dry the neutralized material to obtain 160.4g, add 1.0g of solid organic acid regulator, and send it to the milling system for grinding and homogenizing, the pH value of the powder is 7.9 ;

[0052] (4) Dealcoholization: Use hot air to reduce the partial pressure of fatty alcohol to remove most of the volatile lauryl alcohol from the ground material, and use the fat recovery system to recover 2.5g of a...

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Abstract

Disclosed is a preparation device and method of pharmaceutical adjuvant sodium dodecyl sulfate. The preparation device comprises a sulfonation reactor, the top of the sulfonation reactor is provided with an SO3 sulfonating agent feed port and a dodecanol feed port, and the bottom of the sulfonation reactor is provided with an acid ester discharge port; the acid ester discharge port is connected with the feed port of the neutralizer; an alkali feeding hole is formed in the neutralizer; an outlet of the neutralizer is connected with an inlet of the homogenizing tank, a discharge port in the bottom of the homogenizing tank is connected with the feeder, and the feeder is connected with the dryer; an outlet of the dryer, a discharge port of the quantitative feeder and the air purifier are connected to the cyclone filter through air supply pipelines; the upper end of the cyclone filter is connected with the induced draft fan I, and the bottom is connected with a grinding system; the grindingsystem is connected with a secondary drying machine, and the secondary drying machine is connected with an induced draft fan II and a powder homogenizer respectively; and the induced draft fan II isconnected with a fatty alcohol recovery system. The drying process is safe and stable, the inorganic salt content is low, and the product is not easy to precipitate.

Description

technical field [0001] The invention relates to a preparation device and method of sodium lauryl sulfate as a medicinal auxiliary material, and is especially suitable for preparing pharmaceutical powdery sodium lauryl sulfate with low inorganic salt and low pH value. Background technique [0002] Sodium lauryl sulfate is often used as emulsifier, dispersant and other pharmaceutical excipients in pharmaceuticals. The alkalinity is less than 0.6ml (0.1N hydrochloric acid solution), and the pH value should not be too high. In addition, sodium lauryl sulfate is a heat-sensitive and acid-unstable surfactant. It is easy to become rancid and decompose during the drying process, resulting in a decline in product quality. Inhomogeneous, it is easy to rancid and decompose if it sticks to the equipment. When using 30% liquid material for spray drying, the powder is easy to stick to the tower, and the high temperature for a long time will cause black spots in the product. Therefore, u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C303/24C07C303/44C07C305/04
CPCC07C303/24C07C303/44C07C305/04
Inventor 汪家众祝红元李静陈秀平谢淑皖刘红星
Owner 江苏优扬药业有限公司
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