Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compositions and methods for intranasal delivery of pregnenolone

A technology of pregnenolone and intranasal administration, applied in the directions of drug combination, liquid delivery, ointment delivery, etc., can solve problems such as application limitation and toxicity, and achieve the effect of improving cognitive function

Pending Publication Date: 2021-03-16
马特恩制药股份公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the main strategy to increase acetylcholine activity in the brain of patients with reduced acetylcholine transmission is the administration of acetylcholinesterase inhibitors, but their use is limited due to their toxicity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for intranasal delivery of pregnenolone
  • Compositions and methods for intranasal delivery of pregnenolone
  • Compositions and methods for intranasal delivery of pregnenolone

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0098] Example 1: Intranasal administration of pregnenolone ipsilaterally into one nostril increases acetylcholine activity.

[0099] A two-way ANOVA paired comparison of within-subjects ANOVA for repeated measures was performed to assess the unilateral intranasal administration of pregnenolone (11.2 milligrams per milliliter (mg / mL)), ipsilateral hemisphere and vehicle, contralateral Hemispheric effects on extracellular acetylcholine (Ach) release in the amygdala of each animal, as figure 1 shown. The number of animals used for analysis in the amygdala was: n=10.

[0100] There was a statistically significant difference between the extracellular release of Ach in the two amygdala hemispheres (ipsilateral and contralateral) of each animal, F(1 / 9)=40.195; Wilks λ (Wilks 'Lambda) = .183, p<0.005, partial n squared = .817. A higher increase in extracellular acetylcholine levels was found in the ipsilateral amygdala.

[0101] Independent t-tests (two-tailed) were performed to...

example 2

[0107] Example 2: Administration of pregnenolone in both nostrils increases acetylcholine activity in the amygdala and hippocampus.

[0108] Between- and within-subjects analyzes of variance were performed to assess intranasal administration of pregnenolone (PRG) (5.6 mg / mL (mg / mL), 11.2 mg / mL (mg / mL)) or vehicle in the forehead. Effects in lobar cortex, hippocampus and amygdala. The number of animals studied for analysis of the frontal cortex was: n=7 for the vehicle group, n=5 for the PREG 5.6 mg / mL dose group, and n=6 for the PREG 11.2 mg / mL dose group. The number of animals studied for analysis of the hippocampus was: n=6 for the vehicle group, n=7 for the PREG 5.6 mg / mL dose group, and n=5 for the PREG 11.2 mg / mL dose group. The number of animals studied for analysis of the amygdala (excluding animals 38 and 39) were: n=7 for the vehicle group, n=5 for the PREG 5.6 mg / mL dose group, n=5 for the PREG 11.2 mg / mL dose group 4.

[0109] Such as image 3 As shown in A, nei...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to methods of increasing activity of the neurotransmitter acetylcholine in specific brain regions to treat diseases or disorders associated with reduced acetylcholine activity.In particular, the methods relate to intranasal administration of pregnenolone in only one nostril increasing acetylcholine activity only in the amygdala corresponding to this nostril, thus, providingipsilateral increase of acetylcholine activity.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application 62 / 658,946, filed April 17, 2018, the entire contents of which are incorporated herein by reference. technical field [0003] Described herein are compositions and methods for the intranasal delivery of pregnenolone, eg, useful for increasing the activity of acetylcholine in specific brain regions. Background technique [0004] Neurosteroids and neurotransmitters are compounds that are active in the brain with specific roles in regulating normal brain function, including regulating cognition, feeding, mood, motivation, and motor skills. See Zheng, P., "Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance," Advances in Neurobiology (Prog. Neurobiol.), 89, 134-152 (2009). Abnormal neurosteroid and neurotransmitter function and / or concentrations are associated with many central nervous system (CN...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/06A61K47/14A61K31/573
CPCA61K9/0048A61K9/06A61K31/573A61K47/14A61P25/00A61K9/0043
Inventor C·马特恩
Owner 马特恩制药股份公司
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com