Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of lauric acid in improving animal reproductive function damage

A technology of animal reproduction and lauric acid, applied in animal feed, anhydride/acid/halide active ingredients, applications, etc., can solve the problems of reproductive function damage, affecting the promotion and application of lauric acid, and estrous cycle disorder

Inactive Publication Date: 2021-04-06
SOUTH CHINA AGRI UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the research on improving the animal reproductive function damage caused by high-fat diet, especially the improvement of estrous cycle disorder and abnormal glucose and lipid metabolism in high-fat diet animals, is still blank, and there are no relevant technical reports, which also affects the Further popularization and application of lauric acid
[0006] Through the above analysis, the existing problems and defects of the prior art are: in the prior art, there are few studies on the improvement of animal reproductive performance damage and abnormal glucose and lipid metabolism induced by high-fat diets, and there is no use of lauric acid for the treatment of high-fat diets. Improving technology for diet-induced animal reproductive performance impairment and abnormal glucose and lipid metabolism

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of lauric acid in improving animal reproductive function damage
  • Application of lauric acid in improving animal reproductive function damage
  • Application of lauric acid in improving animal reproductive function damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Lauric acid can improve the abnormality of the estrus cycle in mice fed with high fat

[0038] 1. In order to study the effect of lauric acid on the estrous cycle of high-fat fed mice, 8-week-old female C57BL / 6 mice were used as the research object.

[0039] 2. Experimental method

[0040] (1) Animal feeding method: 1 animal / cage, single breeding; feeding temperature and humidity: 24-26°C, 40%-60%; 12h:12h day and night intermittent lighting; feeding conditions are always kept stable to ensure the accuracy of the test results reliability. During the breeding period, the animals had free access to food and drinking water, and the feed and drinking water were provided by Guangdong Medical Experimental Animal Center.

[0041] (2) Grouping and treatment of animals: 8-week-old mice were randomly divided into 3 groups: control group, high-fat group, and high-fat+lauric acid group, with 8 mice in each group. The mice in the control group were fed with normal diet...

Embodiment 2

[0046] Embodiment 2 lauric acid can improve the intolerance of glucose and insulin in high-fat fed mice

[0047] 1. In order to further study the effect of lauric acid on glucose metabolism in high-fat fed mice, glucose and insulin tolerance experiments were carried out on mice at 17 weeks. The day before the glucose tolerance test, the mice were fasted overnight (20:00-08:00), and the mice were gavaged with glucose, the amount of gavage was 1g glucose / kg mouse body weight, and the test and records were performed at 0 and 30 Blood glucose at 1 minute, 60 minutes, 90 minutes, and 120 minutes. On the morning of the insulin resistance experiment, the mice were fasted for 4 hours, and insulin was injected intraperitoneally to the mice. The amount of insulin injected was 1U insulin / kg mouse body weight, and the 0, 30, 60, 90 and 90 minutes of the experiment were detected and recorded. Blood glucose at the 120-minute time point.

[0048] 2. The result is as follows figure 2 Show...

Embodiment 3

[0051] Embodiment 3 lauric acid can change the lipid composition in the serum of mice fed with high fat

[0052] 1. In order to further study the effect of lauric acid on the lipid metabolism of high-fat-fed mice, on the day of the end of the experiment, the mice were anesthetized with carbon dioxide and sacrificed. The serum of the mice was collected and sent to the company for serum lipidomic analysis.

[0053] 2. The result is as follows image 3 Shown:

[0054] (1) if Figure 8 As shown in A, compared with the high-fat group, adding lauric acid to the high-fat diet can up-regulate 19 lipids in serum and down-regulate 2 lipids. Such as Figure 9 As shown, the figure shows 21 lipids that were specifically up-regulated and down-regulated by the addition of lauric acid in the high-fat diet compared with the high-fat group. The experimental results showed that adding lauric acid to the high-fat diet could greatly up-regulate the contents of sphingomyelin and lysolecithin in...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of animal reproduction and development, and discloses application of lauric acid in improving animal reproduction function damage, and the lauric acid is directly added into animal feed, so the animal reproduction function damage and abnormal glycolipid metabolism caused by high-fat diet can be improved. The invention overcomes the defects of research on improvement of animal reproductive performance impairment and abnormal glycolipid metabolism induced by high fat diet in the prior art, and provides application of lauric acid in improvement of animal reproductive performance impairment and abnormal glycolipid metabolism induced by high fat diet. The application range of lauric acid is widened, the reproductive performance damage of animals caused by high-fat diet is improved, and the method is a technology for improving the reproductive performance damage of animals caused by high-fat diet through a nutrition regulation and control means, has important significance for animal production and human health, and provides a a powerful technical theoretical basis for application of lauric acid in improvement of reproductive function damage of high-fat diet animals.

Description

technical field [0001] The invention belongs to the technical field of animal reproduction and development, and in particular relates to the use of lauric acid in improving animal reproductive function damage. Background technique [0002] At present, in daily life, production practice and clinical experiments, long-term consumption of high-fat food can cause obesity in animals and humans and lead to obesity-related metabolic diseases, such as fatty liver, diabetes and polycystic ovary syndrome. After the female animal reaches sexual maturity, there will be periodic follicle development, ovulation and sex hormone secretion, which is called the estrus cycle. The estrous cycle of female animals is divided into preestrus, estrus, postestrus and interestrus. Animal estrous cycle is an important criterion for judging animal reproductive function. However, female animals that eat too much high-fat food often have symptoms such as abnormal estrus, high androgen, and ovulation dis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/20A61P15/08A23K20/10
CPCA61K31/20A23K20/10A61P15/08
Inventor 王松波江青艳张枫琳束刚朱晓彤王丽娜高萍
Owner SOUTH CHINA AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com