Application of ginsenoside Re and lysozyme in preparation of medicine for treating or preventing abdominal aortic aneurysm

A technology for abdominal aortic aneurysm and ginsenoside, which is applied in the field of medicine to achieve the effects of inhibiting growth, delaying progress and having broad application prospects

Active Publication Date: 2021-04-16
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant report on the combined use of ginsenoside Re and lysozyme for the treatment and prevention of abdominal aortic aneurysm

Method used

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  • Application of ginsenoside Re and lysozyme in preparation of medicine for treating or preventing abdominal aortic aneurysm
  • Application of ginsenoside Re and lysozyme in preparation of medicine for treating or preventing abdominal aortic aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Study on Drug Efficacy of Inhibiting Abdominal Aortic Aneurysm

[0018] 1. Establishment of Abdominal Aortic Aneurysm Model

[0019] Experimental animals: C57B / 6J mice, 12 weeks old, SPF grade, male, body weight 20±2g, were purchased from the Experimental Animal Center of Hebei Medical University.

[0020] Mice were raised in SPF grade animal rooms, kept at 50-60% humidity and 22-24°C. The photoperiod is light from 7:00-19:00 and dark from 19:00-7:00. In a sterile environment, the abdomen of mice was subcutaneously anesthetized with 10% chloral hydrate, and the abdomen of mice was routinely prepared for skin disinfection. Use ophthalmology scissors to make an incision about 1.5 cm from the iliac crest on both sides to the intersection point of the midline to the head side, and cut the peritoneum deeply. , widen the field of view, expose the abdominal aorta, carefully separate the two sides of the artery, peel off the abdominal aorta at the branch of the ilia...

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Abstract

The invention relates to the application of ginsenoside Re and lysozyme in preparation of a medicine for treating or preventing abdominal aortic aneurysm. Experiments show that ginsenoside Re and lysozyme are combined for use, so that the growth of abdominal aortic aneurysm can be effectively inhibited, and the progress of abdominal aortic aneurysm is delayed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of ginsenoside Re and lysozyme in the preparation of medicines for treating or preventing abdominal aortic aneurysm. Background technique [0002] Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease, characterized by structural destruction of the abdominal aortic wall, which gradually expands into a degenerative lesion of a pulsatile mass, whose diameter exceeds 1.5 times the normal diameter. body rupture, the case fatality rate is as high as 80%. The main patients with abdominal aortic aneurysm are elderly patients. The incidence rate of abdominal aortic aneurysm is 5 times higher in men than in women, and it is as high as 8% in men over 65 years old. It is an important cause of death in elderly men. The pathogenesis of abdominal aortic aneurysm originates from inflammation on the arterial wall. The infiltration of inflammatory cells causes th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K31/704A61P35/00
Inventor 黄芸佟苗苗王娜赵丽丽史梦召吴雨甘晓若
Owner HEBEI MEDICAL UNIVERSITY
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