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Medicine for treating gastroesophageal reflux disease and preparation method thereof

A gastroesophageal reflux and drug technology, applied in the field of traditional Chinese medicine, can solve the problems of poor curative effect of reflux esophagitis, achieve the effect of improving esophageal mucosal inflammation, improving patients' symptoms, and being convenient to carry and use

Inactive Publication Date: 2021-04-20
山西中医药大学附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defect of poor curative effect in the treatment of reflux esophagitis in the prior art, the present invention provides a drug for treating gastroesophageal reflux disease with reliable curative effect and no side effects and adverse reactions and its preparation method

Method used

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  • Medicine for treating gastroesophageal reflux disease and preparation method thereof
  • Medicine for treating gastroesophageal reflux disease and preparation method thereof
  • Medicine for treating gastroesophageal reflux disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method of the medicine for the treatment of gastroesophageal reflux disease of the present embodiment comprises the following steps: 250g of Scutellaria baicalensis, 150g of Coptidis Rhizome, 150g of dried ginger, 150g of Radix Ginseng, 250g of Pinellia chinensis, 150g of longan longan, 150g of patchouli, and 800g of Magnolia officinalis 150g of licorice, mix evenly, add 10 times the weight of the drug in water, soak for 24 hours, decoct three times, 2 hours each time, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.08, clear paste, dry under reduced pressure, and pulverize into a fine powder, add the above-mentioned fine powder and appropriate amount of starch, mix well, and make granules.

[0022] Preferably, the decompression conditions between the decoction and the concentration of the filtrate are vacuum: -0.03MPa, temperature: 70°C; the conditions for decompression drying of the clear paste a...

Embodiment 2

[0025] The preparation method of the medicine for the treatment of gastroesophageal reflux disease of the present embodiment comprises the following steps: 300g of Scutellaria baicalensis, 180g of Coptidis Rhizome, 180g of dried ginger, 180g of Radix Ginseng, 300g of Pinellia chinensis, 180g of longan longan, 180g of Patchouli, and 900g of Magnolia officinalis 180g of licorice, mixed evenly, adding 10 times the weight of the drug in water, soaking for 24 hours, decocting three times, 2 hours each time, combining the decoction, filtering, concentrating the decompression filtrate to a relative density of 1.11, clear paste, drying under reduced pressure, crushing into a fine powder, add the above-mentioned fine powder and appropriate amount of starch, mix well, and make granules.

[0026]Preferably, the decompression conditions between the decoction and the concentration of the filtrate are vacuum degree: -0.04MPa, temperature: 75°C; the conditions for decompression drying of the ...

Embodiment 3

[0029] The preparation method of the medicine for the treatment of gastroesophageal reflux disease of the present embodiment comprises the following steps: 350g of Scutellaria baicalensis, 200g of Coptidis Rhizoma, 200g of dried ginger, 200g of Radix Ginseng, 350g of Pinellia chinensis, 200g of Piper longum, 200g of Patchouli, and 1000g of Magnolia officinalis 200g of licorice, mixed evenly, adding 10 times the weight of the drug in water, soaking for 24 hours, decocting three times, 2 hours each time, combining the decoction, filtering, concentrating the decompression filtrate to a relative density of 1.13, clear paste, drying under reduced pressure, crushing into a fine powder, add the above-mentioned fine powder and appropriate amount of starch, mix well, and make granules.

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Abstract

The invention discloses a medicine for treating gastroesophageal reflux disease and a preparation method thereof. The preparation method comprises the following steps of uniformly mixing 250-350 g of radix scutellariae, 150-200 g of rhizoma coptidis, 150-200 g of rhizoma zingiberis, 150-200 g of radix ginseng, 250-350 g of rhizoma pinelliae preparata, 150-200 g of fructus piperis longi, 150-200 g of herba pogostemonis, 800-1000 g of cortex magnoliae officinalis and 150-200 g of radix glycyrrhizae, adding water with the weight 10 times that of the medicines, performing soaking for 24 hours, performing decoction for 2 hours each of three times, combining decoction solutions, performing filtration, concentrating a filtrate under reduced pressure to obtain clear paste with the relative density of 1.08, performing drying under reduced pressure, performing crushing into fine powder, adding the fine powder and a proper amount of starch, and performing uniform mixing to obtain granules. According to the invention, the defect that in the prior art, the curative effect of treating reflux esophagitis is poor is overcome. The medicine is refined in formula, reasonable in compatibility, reliable in curative effect after being clinically used for years and free of any toxic and side effects and adverse reactions.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to a medicine for treating gastroesophageal reflux disease. The invention also relates to a preparation method of the medicine. Background technique [0002] Reflux esophagitis (RE) is an inflammatory lesion of the esophagus caused by the reflux of gastric and duodenal contents into the esophagus. Endoscopically, the damage of the esophageal mucosa is manifested as esophageal erosion and / or esophageal ulcer. The pathogenesis of reflux esophagitis is still unclear, and many factors are involved. The main pathophysiological mechanism is the decline of anti-reflux defense mechanism (transient lower esophageal sphincter relaxation, weakened anti-reflux effect of diaphragmatic angle, hiatal hernia, etc.) ) and the result of enhanced attack of reflux on the esophageal mucosa. Reflux includes acid reflux and non-acid reflux. It is generally believed that acid reflux is the mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/04
Inventor 杨丽芳郝旭亮王雁彬冯玛丽张越师晶晶
Owner 山西中医药大学附属医院
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