Supercharge Your Innovation With Domain-Expert AI Agents!

A kind of Huanglian Jiedu decoction split components and its application in atopic dermatitis

A technology of Coptidis Jiedu Decoction and atopic dermatitis, applied to medical preparations containing active ingredients, drug combinations, skin diseases, etc., can solve the problems of large dosage, large side effects, inconvenient preparations, etc., and achieve the split method Convenience, clear ingredient content, and the effect of avoiding ingredient loss

Active Publication Date: 2022-03-29
台州市中心医院
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Huanglian Jiedu Decoction, as a Chinese medicine compound, has a large dosage, inconvenient preparation and large side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of Huanglian Jiedu decoction split components and its application in atopic dermatitis
  • A kind of Huanglian Jiedu decoction split components and its application in atopic dermatitis
  • A kind of Huanglian Jiedu decoction split components and its application in atopic dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The present invention provides a split component of Huanglian Jiedu Decoction, which is obtained by the following split method:

[0023] (1) Weigh 300g of Coptidis rhizome, 200g of Scutellaria baicalensis, 200g of Cortex Phellodendron, and 300g of Gardenia, and after cutting and grinding, the mixture is obtained. After the mixture is soaked in 5L of water for 2h, it is heated to 100°C for extraction for 2h. Filter out the medicinal liquid while it is hot, repeat the above extraction process until the medicinal liquid is colorless, and combine the extracted medicinal liquid.

[0024] (2) Concentrate the extracted medicinal solution to 3.2L under reduced pressure, then add ethanol, and carry out alcohol precipitation. During alcohol precipitation, the alcohol content of ethanol is 75%, and refrigerate below 4°C for 12 hours to obtain alcohol precipitation solution, and suction filter the alcohol precipitation solution , ultrasonically washing the filter residue with ethyl...

Embodiment 2

[0059] The present invention provides a split component of Huanglian Jiedu Decoction, which is obtained by the following split method:

[0060] (1) Weigh 300 g of Coptis Rhizoma, 200 g of Radix Scutellariae, 200 g of Phellodendron Phellodendron, and 300 g of Gardenia, and after cutting and grinding, the mixture is obtained. After the mixture is soaked in 7 L of water for 2 hours, it is heated to 100° C. for extraction for 2 hours. Filter out the medicinal liquid while it is hot, repeat the above extraction process until the medicinal liquid is colorless, and combine the extracted medicinal liquid.

[0061] (2) Concentrate the extracted medicinal solution to 3.2L under reduced pressure, then add ethanol, and carry out alcohol precipitation. During alcohol precipitation, the alcohol content of ethanol is 75%, and refrigerate below 4°C for 24 hours to obtain alcohol precipitation solution, and suction filter the alcohol precipitation solution , ultrasonically washing the filter r...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses split components of Huanglian Jiedu Decoction and its application in atopic dermatitis, and belongs to the technical field of extracting active parts of traditional Chinese medicine compound recipes. The Coptidis Jiedu Decoction splits components by extracting Coptis chinensis, Scutellaria baicalensis, Phellodendron Phellodendron, and Gardenia, followed by ethanol precipitation of the medicinal solution, retaining the filtrate and extracting to obtain petroleum ether extract, and extracting the extracted water layer The chromatographic column separation is carried out to obtain the polysaccharide fraction of Huanglian Jiedu Decoction, the water washing fraction of Huanglian Jiedu Decoction, the 40% alcohol washing fraction of Huanglian Jiedu Decoction, and the 90% alcohol washing fraction of Huanglian Jiedu Decoction. The anti-atopic dermatitis research of the components obtained by the separation method of the present invention shows that the polysaccharide component of Huanglian Jiedu Decoction and the 40% alcohol washing component of Huanglian Jiedu Decoction have better anti-atopic dermatitis effects.

Description

technical field [0001] The invention belongs to the technical field of extracting active parts of traditional Chinese medicine compound, in particular, it relates to split components of Huanglian Jiedu Decoction and its application in atopic dermatitis. Background technique [0002] Atopic dermatitis (AD), also known as atopic dermatitis, atopic dermatitis, etc., is a chronic relapsing, pruritic, inflammatory skin disease characterized by chronic inflammation, altered immune response and The epidermal barrier dysfunction is characterized clinically by repeated episodes of eczema-like dermatitis, accompanied by inflammation, itching, crusting, and dryness. As a chronic disease, AD occurs in patients of all ages: 15% to 30% begin in childhood, 2% to 10% of adults are affected by AD, and approximately 40%-80% of patients have Family history of allergies. [0003] Many studies have confirmed that Huanglian Jiedu Decoction is an effective compound for the treatment of atopic de...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P17/00A61K31/715
CPCA61K36/718A61K36/539A61K36/756A61K36/744A61K31/715A61P17/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor 徐煜彬王文杰陈赛贞
Owner 台州市中心医院
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com