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A compound puerarin preparation

A technology of puerarin and preparations, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of not meeting the clinical requirements of cardiovascular and cerebrovascular diseases and unsatisfactory treatment of cerebrovascular diseases, and achieve clinical The application dose is safe, the active ingredient content is clear, and the effect of high bioavailability

Inactive Publication Date: 2010-10-13
程高楼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent application provides patients and medical workers with a kind of puerarin dripping pills with rapid drug release, rapid effect, less toxic and side effects, and clear active ingredients for cardiovascular diseases, this patent application ignores the fact that the human body has blood-brain Barrier, it is difficult for drugs to enter the brain tissue, so the patent application is still not ideal for the treatment of cerebrovascular diseases, and cannot meet all clinical requirements for the prevention and treatment of cardiovascular and cerebrovascular diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: compound puerarin dropping pill (A) preparation method

[0033] Prescription: Puerarin 300.00g

[0034] Ice flakes 100.00g

[0035] Musk 50.00g

[0036] Macrogol 4000 400.00g

[0037] Made into 10000 capsules

[0038] Preparation method: Take the prescribed amount of polyethylene glycol 4000 and melt it; take 350mL of absolute ethanol, add puerarin, borneol, and musk and stir to dissolve; mix the liquid medicine with the melted polyethylene glycol 4000, continue stirring, and evaporate Remove ethanol, put it in a preheated dropping pill machine, keep it warm at 90°C, and use methyl silicone oil as a coolant to drop it into pills.

Embodiment 2

[0039] Embodiment 2: compound puerarin dripping pill (B) preparation method

[0040] Prescription: Puerarin 250.00g

[0041] Ice flakes 125.00g

[0042] Polyethylene glycol 6000 430.00g

[0043] Made into 10000 capsules

[0044]Preparation method: Take the prescribed amount of polyethylene glycol 6000 and melt it; take 300mL of absolute ethanol, add puerarin and borneol, stir to dissolve; mix the liquid medicine and melted polyethylene glycol 6000, continue to stir, and wave away Ethanol is placed in a preheated pill dropping machine, kept at 88°C, and methyl silicone oil is used as a coolant to drip into pills.

Embodiment 3

[0045] Embodiment 3: the preparation of compound puerarin injection

[0046] 1. Prescription

[0047] Puerarin 200g

[0048] Musk 30g

[0049] Hydroxypropyl Beta Cyclodextrin 15g

[0050] Made 1000 pieces

[0051] 2. Preparation process

[0052] Weigh 30g of musk, add 15g of hydroxypropyl beta cyclodextrin to aid dissolution, add 200g of puerarin and mix evenly, add water for injection to 8000ml, warm to dissolve, add activated carbon for decolorization, remove heat source, filter the activated carbon with a sand stick, add Water for injection to 10,000ml, adjust the pH value to 6.0-7.0, and test its content. If it is qualified, it will be finely filtered through a 0.22μm microporous membrane, filled in a 10ml ampoule, sterilized for 30 minutes, and then inspected by light after cooling. After passing the inspection, the finished water needle can be obtained.

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Abstract

The invention discloses a compound preparation for treating cardiovascular and cerebrovascular diseases, which comprises the constituents of (by weight percent) puerarin 1 part, borneol 0.1-2 parts, and pharmaceutically acceptable carrying agents or auxiliary materials.

Description

technical field [0001] The invention relates to a compound preparation for treating cardiovascular and cerebrovascular diseases, in particular to a compound puerarin preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases, and are the number one killer of human beings. Because cardiovascular and cerebrovascular diseases are characterized by chronicity and suddenness, and can cause death in severe cases, the drugs used to treat cardiovascular and cerebrovascular diseases are often chemical drugs, but these drugs often produce side effects (such as gastrointestinal reactions), toxic reactions (such as toxicity such as damage to circulation, respiratory and nervous system functions), and a series of adverse reactions such as drug withdrawal reactions; so people are increasingly relying on Chinese patent medicines to treat cardiovascular and cerebrovascular diseases. However, traditional Chinese patent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/00A61K31/045A61K31/7048A61K9/16A61K9/48A61K9/20A61K35/55A61K9/08
Inventor 程高楼
Owner 程高楼
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