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In-vitro liver support system

A support system and liver technology, applied in the field of medical devices, can solve the problems of poor use of the bioartificial liver system, and achieve the effect of convenient replacement and effective circulation

Active Publication Date: 2021-05-07
山东壹瑞特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical problem that the bioartificial liver system in the prior art is not effective, and provides an extracorporeal liver support system therapy

Method used

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  • In-vitro liver support system
  • In-vitro liver support system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 A kind of extracorporeal liver support system

[0035] An extracorporeal liver support system, which includes a blood circulation tube connected to each device, a blood pump connected to the patient's pipeline to ensure the speed of blood extracorporeal circulation, and an ultrafiltrate generator that realizes filtration and cytoplasmic separation; The ultrafiltrate pump that filters out the plasma or ultrafiltrate transmission speed; the cell bioreactor connected after the ultrafiltrate pump to process the substances in the plasma or ultrafiltrate; the cell bioreactor connected effectively to filter out what may remain The cell filter of cells in the cytoplasm or ultrafiltrate; the ultrafiltrate generator also stretches out a connecting tube to connect back to the patient's blood circulation line, and it is characterized in that the cell filter is connected back to the patient's blood circulation line (circulation Pipeline) section or connected to the fron...

Embodiment 2

[0050] Embodiment 2 A kind of extracorporeal liver support system

[0051]An extracorporeal liver support system, which includes blood circulation or flow pipelines connected to various devices, a blood pump that ensures the speed of extracorporeal circulation of blood connected to the patient's pipeline, and an ultrafiltrate generator that realizes filtration and cytoplasmic separation; guarantees ultrafiltration The ultrafiltrate pump that filters out the plasma or ultrafiltrate transmission speed of the liquid generator; the cell bioreactor connected after the ultrafiltrate pump to process the substances in the plasma or ultrafiltrate; the cell bioreactor connected effectively to filter out the possibility A cell filter for cells remaining in the cytoplasm or ultrafiltrate; a connecting tube protrudes from the ultrafiltrate generator to connect to the cell reactor circulation line, which is characterized in that the cell filter is connected back to the patient's circulation ...

Embodiment 3

[0067] Embodiment 3 A kind of extracorporeal liver support system

[0068] An extracorporeal liver support system, which includes a blood circulation pipeline connected to each device, a blood pump connected to the patient pipeline to ensure the speed of blood extracorporeal circulation, and an ultrafiltrate generator that realizes filtration and cytoplasmic separation;

[0069] The ultrafiltrate pump that ensures the transmission speed of the ultrafiltrate generator to filter out the plasma or ultrafiltrate; the cell bioreactor connected after the ultrafiltrate pump to process the substances in the plasma or ultrafiltrate; the cell bioreactor connected effectively A cell filter that filters out cells that may remain in plasma or ultrafiltrate; the cell filter is connected back to the patient's circulation line or connected to the front end of the ultrafiltrate generator, and a return blood heater is set on the return to the patient's circulation line An infusion pump for infu...

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Abstract

An in-vitro liver supporting system comprises a blood circulation pipeline, a blood pump and an ultrafiltrate generator which are communicated with all structures, an ultrafiltrate pump, a cell bioreactor, a cell filter, a calcium ion infusion pump and a calcium ion detection device; the ultrafiltrate generator is further connected with a connecting pipe which is connected back to a patient blood circulation pipeline, and a citrate infusion pump for infusing anticoagulant substances is arranged in front of the ultrafiltrate generator; the calcium ion infusion pump provides sufficient calcium ions to bind to the citrate; the blood circulation pipeline is provided with a plurality of pressure detection devices for detecting whether the pipeline is smooth or not; first substance detection devices for detecting substances capable of reflecting cell activity in the bioreactor are arranged in front of and behind the cell bioreactor, and a second infusion pump for supplementing substances in circulating blood and a second substance detection device capable of detecting the concentration of infusion substances in the circulating blood are arranged on the blood circulation pipeline; and the second substance detection device is connected with the corresponding second infusion pump, and the second substance detection device adjusts the input rate of the infusion pump in a feedback manner.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to the technical field of medical devices for treating liver diseases, and specifically relates to an extracorporeal liver support system. Background technique [0002] Severe liver disease / liver failure caused by hepatitis, drugs, toxins and tumors is still one of the leading causes of critical illness and death worldwide. Statistics from the World Health Organization show that the number of people who have been infected with hepatitis in the world has reached more than 2 billion, and about 500 million people have deteriorated to severe liver diseases, and the number of people who die of liver diseases every year reaches 1.5 million. In Asia, especially China, this problem is particularly prominent. According to statistics, about 400,000 patients die of liver failure every year, which means that more than 1,000 patients die every day. [0003] The condition of patients wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/18A61M1/36C12M1/34C12M1/12C12M1/00C12M3/00G01D21/02
CPCA61M1/1621A61M1/1698A61M1/3621A61M1/3672A61M1/369C12M47/04C12M41/46C12M23/58C12M41/40G01D21/02A61M2205/18A61M2205/36A61M2202/0413A61M2205/3331A61M2205/3327A61M2205/3324A61M2202/0021
Inventor J·布拉泽顿D·贺阮海斌
Owner 山东壹瑞特生物科技有限公司
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