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Virucidal nanoparticles and use thereof against influenza virus

A nanoparticle and virus-killing technology, which is applied in the direction of antiviral agents, medical preparations of non-active ingredients, drug delivery, etc., and can solve the problems that the demand for drugs has not been met.

Pending Publication Date: 2021-05-07
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the absence of a broad-spectrum effective vaccine, there is an unmet need for drugs against influenza

Method used

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  • Virucidal nanoparticles and use thereof against influenza virus
  • Virucidal nanoparticles and use thereof against influenza virus
  • Virucidal nanoparticles and use thereof against influenza virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0130]Experimental data

[0131]Density test

[0132]The nanoparticles of three different densities of 6-sialic-N-acetyl lactose (6'sln) were synthesized to prove optimal 6'slN density (figure 1 ). Control experiments of the gold nanoparticles of PEG (5) and 3-sialic-N-acetyl lactam amine (3'sln) were also carried out.

[0133]Two-influenza virus strains H1N1 (NETH / 09) and H3N2 (Sing / 04) and a hemata-reaction study were carried out in comparison. LD-6'sln nanoparticles anti-all test viruses half inhibitory concentration (EC50)lowest. In general, the inhibitory effect of nanoparticles on the A subtype is better than the inhibitory effect on the secondary subtype.

[0134]Table 1: Semi - inhibitory concentration of different nanoparticles anti-H1N1 (Neth / 09) strain (EC50) And half cytotoxic concentrations (CC50). The molar concentration is calculated based on nanoparticles and triose / nanoparticles, respectively.

[0135]

[0136]Table 2: EC of different nanoparticles anti-H3N2 SING / 04 strai...

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Abstract

The invention relates to virucidal nanoparticles comprising a trisaccharide moiety and use thereof against influenza virus.

Description

Technical field[0001]The present invention relates to the use of killing viral nanoparticles and anti-flu viruses of triose moieties.Background technique[0002]The influenza virus is the most infectious virus. Every year, different influenza strains are infected with animals and humans, and people who have low-risk babies, elderly and immune function, all of these people have risk of hospitalization and death due to influenza. Therefore, seasonal flu has had a significant impact on social economy. In fact, in developed countries and mainly in developing countries, respiratory diseases will cost a large part of the total health costs. Due to the speed of flu, developing vaccines is still a major challenge. If you only pay attention to the occasional popularity rather than annual outbreaks, the development of vaccines will face greater challenges. This situation constitutes a serious risk to the development time of the new vaccine (average 6 months). In addition, even in the presence o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/54A61K47/69A61K47/61A61P31/16
CPCA61K47/549A61K47/61A61K47/6923A61K47/6929A61P31/16A61K47/6939A61K47/6951
Inventor C·塔帕雷尔武V·卡格诺O·科卡比耶克F·斯泰拉奇
Owner ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)