Application of ruscogenin in preparation of cerebral hemorrhage prevention and treatment medicine

Abstract

The invention discloses application of ruscogenin in preparation of cerebral hemorrhage prevention and treatment medicines, and belongs to the technical field of natural medicines. According to the invention, a mouse cerebral hemorrhage model is induced through brain stereotactic injection collagenase, it is verified that ruscogenin can reduce the mouse cerebral hemorrhage amount, the cerebral hemorrhage area, encephaledema, neurological function damage and blood brain barrier damage, and ruscogenin can be developed or used for preparing the medicine for preventing and treating cerebral hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to the application of ruscogenin in the preparation of medicines for the prevention and treatment of cerebral hemorrhage. Background technique [0002] Intracerebral hemorrhage (ICH), also known as hemorrhagic stroke, refers to hemorrhage caused by rupture of blood vessels in the non-traumatic brain parenchyma. Serious threat to human health ((1) Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and riskfactors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet 2019, 394(10204):1-14.). According to the survey, stroke is the number one cause of death in China, and the incidence of cerebral hemorrhage accounts for about 20%, but it is the subtype of stroke with the highest clinical mortality rate. And the vast majority of survivors left severe neurological deficit symptoms, which brought a heav...

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Problems solved by technology

However, whether ruscogenin can improve

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