Application of effective component group of thrombus-eliminating collateral-dredging formula in treating cerebral hemorrhage

A technology of Xiaoshuan Tongluo and effective ingredients, applied in the field of traditional Chinese medicine, can solve the problems such as no application report of Xiaoshuan Tongluo Prescription, and achieve the effect of significant blood-brain barrier protection, improving neurological function, and reducing the volume of cerebral infarction.

Pending Publication Date: 2020-09-15
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the application of Xiao...

Method used

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  • Application of effective component group of thrombus-eliminating collateral-dredging formula in treating cerebral hemorrhage
  • Application of effective component group of thrombus-eliminating collateral-dredging formula in treating cerebral hemorrhage
  • Application of effective component group of thrombus-eliminating collateral-dredging formula in treating cerebral hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Preparation of active ingredient group of Xiaoshuan Tongluo Formula.

[0027] Xiaoshuan Tongluo Recipe according to the following proportions: 120 parts of Chuanxiong, 90 parts of Salvia, 180 parts of Astragalus, 60 parts of Alisma, 60 parts of Panax notoginseng, 30 parts of Sophora japonica, 60 parts of Guizhi, 60 parts of turmeric, 30 parts of woody fragrance , 2.4 parts of borneol, and 60 parts of hawthorn, firstly use petroleum ether to extract, then continue to extract the extract with different ratios of petroleum ether and acetone (9:1 / 8:2 / 7:3 / 6:4), the residue Partially extracted with ethanol, the extracts were respectively used with acetone, methanol, different proportions of petroleum ether and acetone (9:1 / 7:3 / 1:1 / 3:7) and different proportions of acetone and methanol (9:1 / 7 :3) Extraction is carried out, and the residue continues to be extracted with water. The obtained extracts of ester-soluble and alcohol-soluble fractions were separated by sil...

experiment example 1

[0028] Experimental Example 1. The active ingredient group of Xiaoshuan Tongluo Decoction reduces the volume of cerebral infarction in rats with acute hyperglycemia.

[0029]Experimental materials: Sprague Dawley (SD) rats were purchased from Weitong Lihua (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.). The active ingredient group of Xiaoshuan Tongluo Formula was provided by the National Center for Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences. DMSO was added to aid dissolution during gavage, and the dose was 800mg / kg / d, and the operation was performed after continuous gavage for 7 days. SD rats with a body weight ranging from 240-270 g were anesthetized by intraperitoneal injection of chloral hydrate (350 mg / kg). Intraperitoneal injection of 50% glucose solution 6ml / kg, 30min after operation. The hair around the bregma was shaved, and the skin on the top of the head was cut to expose the bregma. Select 2 mm behind bregma...

experiment example 2

[0035] Experimental example 2. The active ingredient group of Xiaoshuan Tongluo decoction reduces cerebral edema in rats with acute hyperglycemia

[0036] Animal modeling and administration methods are the same as in Example 1. After 24 hours of ischemia, the brain tissue was weighed to measure the wet weight and dry weight, and the water content of the brain was calculated by the wet and dry weight method, which reflected the severity of cerebral edema.

[0037] The result is as figure 2 As shown, the water content of the brain significantly increased after ischemia and hyperglycemia, and the active ingredient group of Xiaoshuan Tongluo Formula significantly reduced the water content of the brain.

[0038] Table 2. Effects of Xiaoshuan Tongluo Decoction active ingredient groups on cerebral edema in rats with acute hyperglycemia.

[0039]

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Abstract

The invention discloses an application of an effective component group of a thrombus-eliminating collateral-dredging formula in preparation of a medicine for treating cerebral hemorrhage. The cerebralhemorrhage comprises simple cerebral hemorrhage stroke, cerebral ischemia hemorrhage caused by hyperglycemia or hypertension after cerebral embolism, and hemorrhage caused by thrombolytic medicine treatment and other factors. Experimental research finds that an effective component group formed by active screening of components obtained by different extraction methods of the thrombus-eliminating and collateral-dredging formula can significantly reduce the volume of cerebral infarction and encephaledema of rats, improve neurological functions and protect blood-brain barrier damage caused by hyperglycemia, thereby reducing the risk and degree of hemorrhagic transformation during hyperglycemia. The effective component group of the thrombus-eliminating and collateral-dredging formula can be used for preparing medicines for treating cerebral hemorrhage and hemorrhage transformation caused by hyperglycemia, relieving secondary hemorrhage in ischemic areas and improving prognosis of patients.

Description

technical field [0001] The invention relates to a new combination and new use of known medicines, in particular to a new use of the active ingredient group of Xiaoshuan Tongluo prescription for treating cerebral hemorrhage, which belongs to the field of traditional Chinese medicine. Background technique [0002] Stroke is a common serious disease among the elderly, and it is the number one cause of death and disability in my country. At present, the incidence of stroke in my country is increasing at a rate of 8.7% per year. WHO predicts that by 2030, the number of deaths of stroke patients in my country will reach 4 million each year. Among the survivors of stroke, as many as 70%-85% of the patients lose their ability to live and work to varying degrees, causing a heavy burden to society and families. Stroke can be divided into ischemic stroke and hemorrhagic stroke, and ischemic stroke patients account for about 80%. [0003] Hemorrhagic transformation (HT) after stroke i...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P25/00A61P7/04A61K31/045
CPCA61K36/258A61K36/537A61K36/236A61K36/734A61K36/489A61K36/9066A61K36/285A61K31/045A61K36/481A61K36/54A61K36/884A61P25/00A61P7/04A61K2236/35A61K2236/33A61K2236/333A61K2236/39A61K2236/331A61K2236/55A61K2300/00
Inventor 杜冠华孔令雷陈燕霞王海港
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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