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Application of icaritin in preparation of medicine for preventing and treating cerebral infarction hemorrhage transformation

A technology of icariin and cerebral infarction, applied in the field of medicine

Pending Publication Date: 2021-09-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature report on the prevention and treatment of hemorrhagic transformation by icarigenin

Method used

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  • Application of icaritin in preparation of medicine for preventing and treating cerebral infarction hemorrhage transformation
  • Application of icaritin in preparation of medicine for preventing and treating cerebral infarction hemorrhage transformation
  • Application of icaritin in preparation of medicine for preventing and treating cerebral infarction hemorrhage transformation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation Example 1 Icarigenin Microemulsion Preparation

[0035]

[0036] Preparation process: Weigh the prescription amount of soybean oil, polyoxyethylene-23-lauryl ether, and 1,2-propylene glycol, mix and stir evenly, then add icarigenin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution and obtain clarification The solution is the icarigenin microemulsion preparation. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

Embodiment 2

[0037] Preparation Example 2 Icarigenin Microemulsion Preparation

[0038]

[0039] Preparation process: Weigh the prescription amount of hydrogenated cocoglyceride, lauroyl polyethylene glycol-32-glyceride, 1,2-propylene glycol, polyethylene glycol 3350, mix and stir evenly, then add icariin to dissolve , can also be ultrasonically treated to accelerate the dissolution to obtain a clear solution, which is the icariin microemulsion preparation. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm.

Embodiment 3

[0040] Preparation Example 3 Icarigenin Injection

[0041]

[0042] Preparation process: Add icariin to the prescribed amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of icaritin in preparation of a medicine for preventing and treating cerebral infarction hemorrhage transformation. The icaritin can significantly reduce primary hemorrhage transformation, asymptomatic hemorrhage transformation and secondary hemorrhage transformation risks caused by the use of thrombolytic drugs, anticoagulant drugs or antiplatelet drugs of cerebral infarction patients, significantly shorten the hemorrhage time and reduce the hemorrhage amount, does not change four coagulation tests and blood routine values when exerting the effects, does not affect the thrombolytic effect of the thrombolytic drugs, has a significant prevention effect for the hemorrhagic infarction which can be determined according to the first cranial CT/MRI, and has important significance for the improvement of the short-term and long-term curative effect of the thrombolytic treatment of infarction diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of icariin in the preparation of medicines for the prevention and treatment of cerebral infarction hemorrhage transformation. Background technique [0002] At present, cardiovascular and cerebrovascular diseases have become the main diseases that endanger the health and life of Chinese people. Among them, stroke has been the second leading cause of death in my country and the second leading cause of death in the world for five consecutive years. By 2010, China's guidelines for the secondary prevention of ischemic stroke and transient ischemic attack (2010 edition) have clearly pointed out that: cerebrovascular disease has become the first cause of disability and death in my country's urban and rural population, And with the arrival of population aging, the incidence of stroke will increase year by year. Therefore, the early prevention and treatment of various types of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10A61P7/04
CPCA61K31/352A61P9/10A61P7/04
Inventor 姚景春李光艳
Owner LUNAN PHARMA GROUP CORPORATION
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