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Method for extracting scopolamine, hyoscyamine and pseudohyoscyamine from flos daturae

A technology of methyl scopolamine and an extraction method, which is applied in the field of natural medicine extraction, can solve the problems of difficulty in improving product purity, many process steps, and many use of auxiliary materials, and achieves high sample extraction volume, overcomes high toxicity and saves process time. Effect

Active Publication Date: 2021-06-01
ZHANG JIA GANG VINSCE BIO PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reported preparation method of scopolamine is to use Inner Mongolia to produce high-content datura as raw material, extract with chloroform-saturated acid aqueous solution, then carry out strong acid cation exchange resin purification to the extract, and then crystallize after multi-step chloroform extraction to obtain high Purity scopolamine hydrobromide, but if this method adopts low-content datura as raw material, problems such as poor enrichment, low recovery, and difficulty in improving product purity will occur in the resin purification stage
[0004] Chinese patent application CN108610339A discloses a process for extracting and separating scopolamine from datura with low content. The process adopts ultrasonic-assisted dichloromethane method for extraction, and then uses acid water and carbon tetrachloride for extraction to realize the initial enrichment of scopolamine. Collect, and then use macroporous resin combined with crystallization technology to purify to obtain high-purity scopolamine hydrobromide. This process has many steps, and there are certain restrictions on the extraction of high-content raw material Dajinhua
However, the product of this method is limited to scopolamine, and more auxiliary materials are used in the extraction process, and the cost is relatively high

Method used

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  • Method for extracting scopolamine, hyoscyamine and pseudohyoscyamine from flos daturae
  • Method for extracting scopolamine, hyoscyamine and pseudohyoscyamine from flos daturae

Examples

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Effect test

Embodiment 1

[0039] A method for extracting hyoscyamine, hyoscyamine and demethacine from datura flower, specifically comprising the following steps:

[0040] (1) Weigh 5kg of datura herbaceae, after pulverization, the length of each piece is about 2-3cm, and place it in the leaching device; pass through 40kg of 80% concentration of methanol aqueous solution, heat to 60°C, dip and extract 3 times, After 4 hours each time, filter the impregnation solution and combine the filtrates, concentrate to obtain 41 g of the desired dry paste, and recover the solvent.

[0041] (2) after the dilute hydrochloric acid solution of 2% is dissolved in the concentration of passing 100ml in 41g dry ointment, flow into self-made tubular continuous extraction device 1 by pipeline (such as figure 1 Shown), continue to feed 2% concentration of dilute hydrochloric acid solution to adjust the pH, and use a pH meter to online control the pH at 5-6.5. Add 250 ml of chloroform to the pH-adjusted aqueous paste acid s...

Embodiment 2

[0050] The only difference from Example 1 is that the dilute hydrochloric acid solution is replaced by formic acid (mass concentration is 8%), and other steps and experimental parameters are the same as in Example 1. 29.3 g of scopolamine, 5.1 g of scopolamine and desmethylscopolamine were obtained, and the extraction rate of scopolamine was 84%, and the extraction rate of scopolamine and demethylscopolamine was 83%.

Embodiment 3

[0052] The only difference from Example 1 is that the ammonia water is replaced by sodium bicarbonate solution (mass concentration is 30%), and other steps and experimental parameters are the same as in Example 1. 28.9 g of scopolamine, 5.2 g of scopolamine and desmethacine were obtained, the extraction rate of scopolamine was 83%, and the extraction rate of scopolamine and desmethacine was 85%.

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Abstract

The invention provides a method for extracting scopolamine, hyoscyamine and pseudohyoscyamine from flos daturae. An impregnation method is combined with an acid extraction method, a water phase and an organic phase are respectively dissolved by using a weak base solution or an acid solution, the pH value is adjusted, chloroform is introduced for extraction, and through a self-made continuous tube type extraction device, a mixture of scopolamine, hyoscyamine and pseudohyoscyamine is obtained through continuous on-line multi-stage circular extraction separation. The method is simple, the extraction rate is high, and the method can be used as a means for large-scale extraction of flos daturae with different contents.

Description

technical field [0001] The invention belongs to the technical field of extraction of natural medicines, and in particular relates to a method for extracting hyoscyamine, hyoscyamine and demethylscopolamine from datura flower. Background technique [0002] Datura datura is the dried flower of Datura datura, a plant in the Solanaceae family. It has the effects of anesthesia, sedation, and analgesia. Dajinhua contains 0.3%-0.43% alkaloids, of which scopolamine accounts for about 85%, hyoscyamine and demethacine account for about 15%. Scopolamine is a tropane-type alkaloid with a bitter, pungent and toxic taste, and can form crystalline salts with various inorganic and organic acids. Scopolamine is the strongest alkaloid in the pharmacological effects of belladonna. It can be used to block the parasympathetic nerves and can also be used as a central nervous system inhibitor. Its effect is similar to belladonna, but the effect is stronger and shorter. [0003] At present, the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 彭学东张梅赵金召
Owner ZHANG JIA GANG VINSCE BIO PHARM
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