Potassium ion sustained and controlled release tablet and preparation method thereof

A slow-release tablet and potassium ion technology, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as increased risk, reduce production costs, and achieve long release times. , the effect of improving uric acid excretion

Pending Publication Date: 2021-06-04
陕西思瑰瑞食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excessive doses may still cause the release to be too fast when first taken, increasing the risk

Method used

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  • Potassium ion sustained and controlled release tablet and preparation method thereof
  • Potassium ion sustained and controlled release tablet and preparation method thereof
  • Potassium ion sustained and controlled release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Potassium ion sustained and controlled release tablet, composed of a tablet core and a sustained release coating, the tablet core includes the following raw materials in parts by weight: 10 parts of potassium citrate, 5 parts of cyclodextrin, and 2 parts of binder , the water balance; the slow-release coating includes the following raw materials in parts by weight: 20 parts of ethyl cellulose, 10 parts of oxidized hydroxypropyl starch, 2 parts of sodium lactate, 3 parts of sodium carboxymethyl cellulose, toughening agent 2 parts, 1 part of coloring agent, 1 part of auxiliary agent, and the balance of solvent.

[0035] The preparation method of the potassium ion sustained and controlled release tablet comprises the following steps:

[0036] (1) Mix potassium citrate and cyclodextrin in parts by weight, after grinding, pass through a 200-mesh sieve, add binder in parts by weight, continue to stir for 8 hours, add water, and continue to stir to make the solution viscous s...

Embodiment 2

[0040] Potassium ion sustained and controlled release tablet, which is composed of a tablet-shaped drug core and a sustained-release coating. The tablet-shaped drug core includes the following raw materials in parts by weight: 15 parts of potassium citrate, 8 parts of cyclodextrin, and 3 parts of binder , the water balance; the slow-release coating includes the following raw materials in parts by weight: 80 parts of ethyl cellulose, 20 parts of oxidized hydroxypropyl starch, 10 parts of sodium lactate, 5 parts of sodium carboxymethyl cellulose, toughening agent 15 parts, 5 parts of coloring agent, 5 parts of auxiliary agent, and the balance of solvent.

[0041] The preparation method of the potassium ion sustained and controlled release tablet comprises the following steps:

[0042] (1) Mix potassium citrate and cyclodextrin in parts by weight, after grinding, pass through a 200-mesh sieve, add binder in parts by weight, continue to stir for 16 hours, add water, and continue t...

Embodiment 3

[0046] Potassium ion sustained and controlled release tablet, consisting of a tablet core and a sustained release coating, the tablet core includes the following raw materials in parts by weight: 13 parts of potassium citrate, 6 parts of cyclodextrin, and 3 parts of binder , the water balance; the slow-release coating includes the following raw materials in parts by weight: 50 parts of ethyl cellulose, 15 parts of oxidized hydroxypropyl starch, 6 parts of sodium lactate, 4 parts of sodium carboxymethyl cellulose, toughening agent 10 parts, 3 parts of coloring agent, 3 parts of auxiliary agent, and the balance of solvent.

[0047] The preparation method of the potassium ion sustained and controlled release tablet comprises the following steps:

[0048] (1) Mix potassium citrate and cyclodextrin in parts by weight, after grinding, pass through a 200-mesh sieve, add binder in parts by weight, continue to stir for 12 hours, add water, and continue to stir to make the solution viscou...

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Abstract

The invention relates to the technical field of potassium ion sustained release, in particular to a potassium ion sustained and controlled release tablet and a preparation method thereof. The potassium ion sustained and controlled release tablet comprises a tablet-shaped drug core and a sustained release coating, wherein the tablet-shaped drug core comprises the following raw materials: 10-15 parts of potassium citrate, 5-8 parts of cyclodextrin, 2-3 parts of a binder and the balance of water; and the sustained release coating comprises the following raw materials: 20-80 parts of ethyl cellulose, 10-20 parts of oxidized hydroxypropyl starch, 2-10 parts of sodium lactate, 3-5 parts of sodium carboxymethyl cellulose, 2-15 parts of a toughening agent, 1-5 parts of a coloring agent, 1-5 parts of an auxiliary agent and the balance of a solvent. According to the potassium ion sustained and controlled release tablet and the preparation method thereof, slow release of potassium ions is achieved, effective absorption of the potassium ions is enhanced, and the potassium ion sustained and controlled release tablet has the effects that slight alkalinity of blood is adjusted, long-acting constant-speed release is achieved, abrasion resistance is good, the toughness of the coating is improved, and the shape or structure of the sustained and controlled release tablet is not damaged.

Description

technical field [0001] The invention relates to the technical field of potassium ion sustained release, in particular to a potassium ion sustained and controlled release tablet and a preparation method thereof. Background technique [0002] Potassium ions are an indispensable nutrient element for the human body and an indispensable substance for the contraction of muscles, especially cardiomyocytes. As the pace of life accelerates, the proportion of plant foods decreases (potassium ions mainly exist in plant-derived foods), and modern people begin to have insufficient potassium ions from normal diets. Although potassium ions are indispensable, short-term large doses of potassium ions will increase the blood potassium concentration instantaneously, which will easily lead to myocardial overexcitation and myocardial infarction. Therefore, for people who need potassium supplementation, only slow potassium supplementation can be used. After potassium ions are absorbed, they are ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/36A61K47/32A61K47/69A61K47/36A61K47/12A61K47/38A61K31/194A61P3/02A61P7/00A61P19/06
CPCA61K9/2027A61K47/6951A61K9/286A61K9/282A61K9/2866A61K9/2893A61K31/194A61P3/02A61P7/00A61P19/06
Inventor 贾毅
Owner 陕西思瑰瑞食品科技有限公司
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