A kind of preparation technology of penicillin preparation

A preparation process, penicillin technology, applied in the direction of packaging automatic control, packaging, sorting, etc., can solve the problems of inability to realize real-time monitoring, inability to achieve comprehensive detection, waste of raw materials, etc., achieve short measurement time, reduce production efficiency, The effect of reducing the defective rate

Active Publication Date: 2021-08-27
SUZHOU ERYE PHARMA CO LTD +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] This detection method is sampling detection, which cannot achieve comprehensive detection, and has hysteresis, cannot realize real-time monitoring, and is easy to waste raw materials

Method used

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  • A kind of preparation technology of penicillin preparation
  • A kind of preparation technology of penicillin preparation
  • A kind of preparation technology of penicillin preparation

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preparation example Construction

[0065] In the entire preparation process of penicillin preparations, the most likely cause of defective products is that the deviation between the filling dose and the standard dose exceeds the specified value. Through long-term production practice, it has been found that more than 90% of the defective products with different weights are caused by insufficient filling dosage caused by the failure of packaging equipment, and the situation of defective products caused by excessive filling dosage is relatively low. few.

[0066] The current weight inspection is by manual sampling, and the proportion of random inspection is low, usually only about 1%. The filling dose of a certain batch is judged by the results of random inspection. This method is less comprehensive and has a lag.

[0067] Based on this, in this embodiment, the following detection process is added to the penicillin preparation preparation process, specifically including the following steps:

[0068] S401. Determ...

Embodiment 1

[0098] Embodiment 1: the preparation technology of penicillin sodium for injection

[0099] Remove the outer packaging of the 7ml molded vials and place them on the bottle unscrambling table. After rejecting unqualified bottles, the undamaged vials are neatly arranged and pushed to the bottle delivery mesh belt to be washed, and then sent to the bottle turntable by the conveyor belt, and then sent to the ultrasonic wave. Bottle washing machine. After ultrasonic cleaning, purified water and water for injection rinse, the cleaned bottles are blown with nitrogen and sent to the mouth of the tunnel oven through a conveyor belt under A-level laminar flow protection, and pushed into the tunnel oven by a bottle pusher for high-temperature sterilization and drying. Among them, the water pressure of purified water is ≥0.2MPa, the water pressure of injection water is ≥0.2MPa, and the pressure of high-pressure nitrogen gas is ≥0.2Mpa.

[0100] Use KSZ1200 / 180 tunnel type sterilization a...

Embodiment 2

[0116] The penicillin sodium of embodiment 1 is replaced by azlocillin sodium, amosodium, ampicillin sodium, oxacillin sodium, furobuta sodium, cloxacillin sodium, mezacillin sodium, piperacillin sodium, and other technological processes are not changed. Change. The results show that the penicillin preparation preparation process of the present invention has an accurate subpackage volume and meets preset requirements.

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Abstract

The invention provides a preparation process and a dose detection device of penicillin drugs for injection. Firstly, the standard dose height after the standard dose of penicillin preparations are filled into the vials and shaken to level off is determined; then the first dose is determined based on the standard dose line height. Preset height; during the subpackaging process of penicillin preparations, use a laser inspection system to detect the highest height of the powder pile formed after penicillin preparations are filled into vials to obtain the first actual height; when the first actual height is lower than At the first preset height, an alarm is given, or the vial is marked or picked out. The invention realizes the on-line dose detection of the piperacillin, ampicillin and other series of penicillin injection sterile powder packaging products, and can quickly detect the products with obviously insufficient filling dose, thereby reducing the defective rate of the products.

Description

technical field [0001] The invention relates to the technical field of preparation of sterile powder medicine for injection, in particular to a preparation process of penicillin preparations for injection and a dose detection device. Background technique [0002] Penicillin antibiotics are a kind of antibacterial drugs commonly used in clinical practice. They are used to treat infectious inflammation caused by various sensitive bacteria. They have the advantages of definite curative effect, low toxicity and low price. Clinically, it is mostly used in the form of sterile powder for injection. According to the provisions of the National Pharmacopoeia, the difference in the filling volume of the sterile powder for injection products should be controlled within a certain range to ensure the accuracy of the dosage. [0003] Through long-term production practice, it has been found that more than 90% of the defective products with different weights are due to the problem of insuff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B07C5/10B07C5/36B07C5/02B65B57/18B65B65/00B65B65/08
CPCB07C5/02B07C5/10B07C5/362B65B57/18B65B65/003B65B65/08
Inventor 陈学文沈灏李志永华军杰吴永锋
Owner SUZHOU ERYE PHARMA CO LTD
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