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Pharmaceutical composition for promoting wound healing after anorectal operation and preparation method thereof

A technology for wound healing and anorectal surgery, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations. The effect of the environment and the simplicity of the preparation method

Inactive Publication Date: 2021-06-18
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem of slow absorption of active ingredients of existing medicaments and inability to efficiently promote wound healing, the present invention provides a pharmaceutical composition for promoting wound healing after anorectal surgery and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] This example provides drug-loaded microemulsion-I and its preparation method.

[0056] The drug-loaded microemulsion in this example is a W / O emulsion, which consists of a water phase, an oil phase, and an emulsifier in a mass ratio of 2:7:1.

[0057] In this example, the oil phase is jojoba oil; the emulsifier is a mixture of Span 80 and Tween 80 with a mass ratio of 8:2.

[0058] The water phase in this example is the water extract of Chinese medicine, which is obtained by water extraction of the following Chinese medicinal materials in parts by mass: 25 parts of Astragalus, 15 parts of Bletilla striata, 10 parts of Angelica sinensis, 10 parts of Coptidis rhizome, 10 parts of Radix Radix and 10 parts of Angelica dahurica.

[0059] The preparation method of the present embodiment drug-loaded microemulsion comprises the following steps:

[0060] Step 1, prepare the aqueous phase:

[0061] Weigh 25 parts of astragalus, 15 parts of bletilla striata, 10 parts of angelica...

Embodiment 2

[0065] This example provides drug-loaded microemulsion-II and its preparation method.

[0066] The drug-loaded microemulsion in this example is a W / O emulsion, which consists of a water phase, an oil phase and an emulsifier in a mass ratio of 3:6:1.

[0067] In this example, the oil phase is comfrey oil; the emulsifier is a mixture of Span 80 and Tween 80 with a mass ratio of 7:3.

[0068] The water phase in this example is the water extract of traditional Chinese medicine, which is obtained by water extraction of the following Chinese medicinal materials in parts by mass: 30 parts of astragalus, 20 parts of bletilla striata, 15 parts of angelica, 15 parts of coptis, 15 parts of isatidis and 15 parts of angelica.

[0069] The preparation method of the present embodiment drug-loaded microemulsion comprises the following steps:

[0070] Step 1, prepare the oil phase:

[0071] Soak 10 parts of comfrey with 5 times the quality of olive oil for 12 hours, fry at 120°C for 2 hours,...

Embodiment 3

[0077] This example provides a pharmaceutical composition for promoting wound healing after anorectal surgery and a preparation method thereof.

[0078] The pharmaceutical composition provided in this example is a cream preparation, including the following components by mass: 15 parts of drug-loaded microemulsion and 75 parts of gel.

[0079] The drug-loaded microemulsion used in this example is the drug-loaded microemulsion-I prepared in Example 1, and the gel is carbomer gel.

[0080] The preparation method steps of pharmaceutical composition are as follows:

[0081] Step 1. Weigh the following components by mass: 15 parts of drug-loaded microemulsion-I and 75 parts of carbomer gel;

[0082] Step 2: After adding carbomer into water to swell at room temperature for 12 hours, adjust the pH value to 7.0 with triethanolamine, add carbomer gel to the drug-loaded microemulsion-I and stir slowly, and stir at 60 rpm for 2 hours to obtain a uniform mixture pharmaceutical compositio...

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Abstract

The invention relates to a pharmaceutical composition for promoting wound healing after anorectal operation and a preparation method thereof, and belongs to the technical field of nursing after anorectal operation. In order to solve the problems that effective components of an existing medicament are slowly absorbed and wound healing cannot be efficiently promoted, the invention provides the pharmaceutical composition for promoting wound healingafter anorectal operation. The pharmaceutical composition is a cream preparation and comprises the following components: a drug-loaded microemulsion, drug-loaded microspheres, stem cell exosome lipidosome and gel. The micron-sized water-in-oil type drug-loaded microemulsion can be rapidly absorbed by a wound surface, the oil phase provides nutritional ingredients, and the water phase rapidly exerts a drug effect and has the effects of astringing and promoting tissue regeneration, relieving swelling and pain, diminishing inflammation and stopping bleeding and preventing wound surface infection; the drug-loaded microspheres can provide sustained-release traditional Chinese medicine components, and are compounded with the drug-loaded microemulsion to further promote wound healing; The stem cell exosome component can go deep into wound tissues, improve the wound microenvironment, promote the growth of the wound tissues and angiogenesis, and accelerate the wound healing.

Description

technical field [0001] The invention belongs to the technical field of anorectal postoperative care, and in particular relates to a pharmaceutical composition for promoting anorectal postoperative wound healing and a preparation method thereof. Background technique [0002] According to the nationwide epidemiological survey of anorectal diseases, the prevalence of anorectal diseases is as high as 51.14%, which is much higher than common diseases such as cardiovascular and cerebrovascular diseases, hypertension, etc. Among them, the prevalence of anorectal diseases in men and women is 51.4% respectively. % and 50.80%, the prevalence rate of people aged 25 to 64 is relatively high, and can gradually increase with age. [0003] Anorectal diseases mainly include hemorrhoids, perianal abscess, anal fistula, anal fissure, etc. The treatment method is mainly surgery, but due to the particularity of the lesion site of anorectal diseases and the special physiological function of the ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/10A61K47/44A61K9/16A61K47/36A61K47/26A61K9/127A61K47/24A61K47/28A61K36/898A61K35/28A61P17/02A61P29/00A61P1/00A61P9/14A61K35/644A61K31/045
CPCA61K9/06A61K9/0014A61K9/1075A61K47/44A61K9/1652A61K9/1617A61K9/127A61K47/24A61K47/28A61K36/481A61K36/898A61K36/232A61K36/718A61K36/195A61K36/315A61K36/889A61K36/896A61K31/045A61K35/644A61K35/28A61P17/02A61P29/00A61P1/00A61P9/14A61K2300/00
Inventor 黄跃南于佳永郭欣
Owner HARBIN MEDICAL UNIVERSITY
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