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Bupi Yichang Gastrointestinal Separation-dissolving Pill and Preparation Method

A gastrointestinal and stomach-dissolving technology, which is applied in the directions of pill delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Qualification, increase in scrap rate and other issues, to achieve the effect of reducing labor, saving material costs, reducing scrap rate and production cost

Active Publication Date: 2022-04-29
GUANGZHOU BAIYUNSHAN CHENLIJI PHARMA FAB CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual production, it often happens that the outer powder cannot coat the enteric-coated pills or is easy to remove the powder, resulting in unqualified product quality, increased scrap rate, and increased costs

Method used

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  • Bupi Yichang Gastrointestinal Separation-dissolving Pill and Preparation Method
  • Bupi Yichang Gastrointestinal Separation-dissolving Pill and Preparation Method
  • Bupi Yichang Gastrointestinal Separation-dissolving Pill and Preparation Method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment is a kind of pill for nourishing the spleen and benefiting the stomach and intestines, and its preparation method is as follows:

[0034] (1) Preparation of the enteric-coated powder: take 5 parts of Yuanhu, 5 parts of lychee core, 3 parts of dried ginger, 5 parts of licorice, 6 parts of Fangfeng, 5 parts of woody fragrance, 5 parts of psoralen, and 15 parts of red stone fat , crushed, that is;

[0035] (2) Preparation of the stomach dissolving powder: take 10 parts of Astragalus membranaceus, 7.5 parts of Codonopsis pilosula, 3 parts of Amomi, 15 parts of Radix Paeoniae Alba, 2.5 parts of Angelica sinensis, 5 parts of Atractylodes Rhizoma Atractylodes Rhizome, 1.5 parts of cinnamon, and pulverize to obtain final product;

[0036] (3) Preparation of binder: get 2% hydroxypropylmethylcellulose (HPMC, viscosity 50mPa.s), 47% ethanol and 51% water, add the described hydroxypropylmethylcellulose in the water, and Stir and dissolve at a temperature of 50-60°...

Embodiment 2

[0043] This embodiment is a kind of pill for nourishing the spleen and benefiting the stomach and intestines, and its preparation method is as follows:

[0044] (1) Preparation of the enteric-coated powder: take 5 parts of Yuanhu, 5 parts of lychee core, 3 parts of dried ginger, 5 parts of licorice, 6 parts of Fangfeng, 5 parts of woody fragrance, 5 parts of psoralen, and 15 parts of red stone fat , crushed, that is;

[0045] (2) Preparation of the stomach dissolving powder: take 10 parts of Astragalus membranaceus, 7.5 parts of Codonopsis pilosula, 3 parts of Amomi, 15 parts of Radix Paeoniae Alba, 2.5 parts of Angelica sinensis, 5 parts of Atractylodes Rhizoma Atractylodes Rhizome, 1.5 parts of cinnamon, and pulverize to obtain final product;

[0046] (3) Preparation of binder: get 1.3% hydroxypropylmethylcellulose (HPMC, viscosity 50mPa.s), 56.7% ethanol and 42% water, add the described hydroxypropylmethylcellulose in the water, and Stir and dissolve at a temperature of 50-6...

Embodiment 3

[0053] This embodiment is a kind of pill for nourishing the spleen and benefiting the stomach and intestines, and its preparation method is as follows:

[0054] (1) Preparation of the enteric-coated powder: take 5 parts of Yuanhu, 5 parts of lychee core, 3 parts of dried ginger, 5 parts of licorice, 6 parts of Fangfeng, 5 parts of woody fragrance, 5 parts of psoralen, and 15 parts of red stone fat , crushed, that is;

[0055] (2) Preparation of the stomach dissolving powder: take 10 parts of Astragalus membranaceus, 7.5 parts of Codonopsis pilosula, 3 parts of Amomi, 15 parts of Radix Paeoniae Alba, 2.5 parts of Angelica sinensis, 5 parts of Atractylodes Rhizoma Atractylodes Rhizome, 1.5 parts of cinnamon, and pulverize to obtain final product;

[0056] (3) Preparation of adhesive: 1% hydroxypropylmethylcellulose (HPMC, viscosity 50mPa.s), 56% ethanol and 43% water. Add the hydroxypropylmethylcellulose into the water, stir and dissolve at 50-60°C, and then add the ethanol to ...

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Abstract

The invention relates to a gastrointestinally dissolving pill for invigorating the spleen and benefiting the intestines and a preparation method thereof. The spleen-invigorating, gastrointestinal, and enteric-soluble pills include an enteric-coated inner pill, a gastric-coated layer, and a transition layer; wherein, the enteric-coated inner pill is made of enteric-coated powder; and the enteric-coated powder is made of raw materials including the following components Made: Yuanhu, litchi core, dried ginger, licorice, windproof, woody, psoralen and red stone fat; the stomach-soluble layer is made of stomach-soluble powder; the stomach-soluble powder is made of raw materials including the following components Made: Radix Astragali, Codonopsis pilosula, Amomi, Radix Paeoniae Alba, Angelica, Atractylodes Rhizoma Atractylodes Rhizome and Cinnamon; The transition layer is prepared by using the stomach-melting powder and an adhesive, and the adhesive includes the following group by weight percentage: Ingredients: hydroxypropyl methylcellulose 0.5-5%, water 20-65%, ethanol 30-75%. The gastro-coated layer and the enteric-coated layer of the Spleen Yichang Gastrointestinal Dissolvable Pill are tightly combined and completely coated, and can effectively ensure timely disintegration and release of the medicine in the stomach and intestinal tract respectively.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a separate dissolving pill for invigorating the spleen and benefiting the intestines and stomach and intestines and a preparation method thereof. Background technique [0002] Chronic nonspecific ulcerative colitis is a relatively common chronic inflammatory bowel disease in the colonic mucosa and submucosa that is prone to repeated attacks in clinical practice. It is clinically characterized by lower abdominal pain, diarrhea or thin stool, mucus or blood in the stool. Due to the long course of the disease, recurrent attacks, difficult to cure, and potential malignant lesions, the patients suffer very much. And because it is an autoimmune disease of unknown cause, there are few good therapeutic methods and medicines at home and abroad. [0003] Chinese patent CN87106202A discloses a preparation process of gastrointestinally soluble Chinese patent medicine pills. Acco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/36A61K9/20A61K47/38A61P1/04A61P1/00A61K33/26
CPCA61K36/66A61K36/77A61K36/9068A61K36/484A61K36/238A61K36/285A61K36/487A61K33/26A61K36/481A61K36/344A61K36/9064A61K36/71A61K36/65A61K36/232A61K36/284A61K36/54A61K9/2866A61K9/2068A61P1/04A61P1/00A61K2300/00
Inventor 彭富全谢嘉伟刘敏石洪超林庆义
Owner GUANGZHOU BAIYUNSHAN CHENLIJI PHARMA FAB CO LTD
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