A hydrogel drug-loaded coating for treatment in oxidative stress environment and preparation method thereof

Abstract

The invention discloses a hydrogel drug-loaded coating for treatment in an oxidative stress environment and a preparation method thereof, comprising the following steps: S1 catechol-modified hyaluronic acid; S2 modified hyaluronic acid and cysteine Amine cross-linking; S3 Preparation of hydrogel drug-loaded coating. By modifying hyaluronic acid and cross-linking, a hydrogel with S-S bonds can be formed, and the hydrogel and allicin are sprayed sequentially on the substrate deposited with polydopamine, which can be prepared for oxidation Hydrogel drug-loaded coatings for stressful environments. The coating can achieve intelligent and precise drug release for specific pathological environments such as myocardial infarction, septic cardiomyopathy, atherosclerosis and other heart diseases caused by oxidative stress, so as to achieve the inhibition of oxidative stress and its subsequent Regulation of inflammatory responses.

Description

technical field [0001] The invention relates to the technical field of preparation of hydrogel carriers, in particular to a drug-loaded hydrogel coating for treatment in an oxidative stress environment and a preparation method thereof. Background technique [0002] According to the statistics of the World Health Organization, cardiovascular disease has become one of the main causes of abnormal human death in the world, and it is the highest morbidity and mortality rate among all diseases in my country, and it is higher than other diseases such as tumors. It poses a huge threat to human health and life. Among them, coronary heart disease (coronary heart disease) is a class of vascular-derived diseases with extremely high hazards caused by atherosclerosis. Atherosclerosis generally refers to lesions that occur in the intima of large and medium arteries, and is a disease caused by abnormal deposition of lipids in the plasma in the intima of the vessel wall. Atherosclerosis is...

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Problems solved by technology

[0006] The current research on the problem of interventional drug-loaded coatings for the treatment of cardiovascular diseases has the following deficiencies: (1) The existing interventional materials mainly use spraying technology, and the bonding force between the coating and the stent is poor. After implantation, the coating It is easy to fall off and has poor adhesion, which is not conducive to cell growth; (2) The coating is mostly made of polymer materials, and the degradation products have certain toxic and side effects. For example, the degradation products of polylactic acid have certain acidity, which will change the physiological local microenvironment , thereby affecting normal physiological functions; (3) Commonly used anticoagulant and antiproliferative drugs, such as rapamycin and paclitaxel, will inhibit hyperplasia in the early stage of treatment, so they will also inhibit the process of endothelialization, thereby causing side effects such as late thrombosis. (4) Gels without dynamic chemical bonds cannot respond to release drugs according to changes in the microenvironment of cardiovascular disease lesions, and cannot treat diseases according to the real-time situation of lesions

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