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Application of flaxseed active polypeptide in preparation of products for preventing, intervening/treating colitis

An active peptide, flaxseed technology, applied in the field of food or medicine, can solve the problem that the effect and mechanism of flaxseed peptides have not been reported.

Pending Publication Date: 2021-07-06
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, scholars at home and abroad have studied and reported various functional activities of flaxseed protein and its active peptides, such as anti-oxidation, antibacterial, anti-hypertensive, and lowering cholesterol. However, the effect of flaxseed peptide on improving colitis Effect and mechanism studies have not been reported

Method used

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  • Application of flaxseed active polypeptide in preparation of products for preventing, intervening/treating colitis
  • Application of flaxseed active polypeptide in preparation of products for preventing, intervening/treating colitis
  • Application of flaxseed active polypeptide in preparation of products for preventing, intervening/treating colitis

Examples

Experimental program
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Effect test

Embodiment 1

[0022] This example further proves the intervention and improvement effect of linseed active polypeptide on ulcerative colitis through animal experiments. The specific experiments are as follows:

[0023] 1. Experimental materials and instruments

[0024] 1.1 Experimental materials: Linseed was purchased from Kunming, Yunnan Province, China.

[0025] 1.2 Main reagents: male C57BL / 6J mice were purchased from Hunan SJA Experimental Animal Co., Ltd.; dextran sodium sulfate (DSS, MW: 40000Da) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; selection medium was purchased from Qingdao Haibo Biology Technology Co., Ltd.; ELISA assay kit was purchased from Nanjing Jiancheng Institute of Bioengineering, China.

[0026] 1.3 Main instruments: FD50R vertical automatic pressure steam sterilizer, Zhiwei (Xiamen) Instrument Co., Ltd.; XMTD-204 digital display constant temperature stirring water bath, Jintan Baita Xinbao Instrument Factory; ALPHA 1-2 LD plus Freeze dry...

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Abstract

The invention discloses application of flaxseed active polypeptide in preparation of products for preventing, intervening / treating colitis, and belongs to the technical field of food or medicine. Animal experiments prove that the flaxseed active polypeptide has a remarkable intervention effect on colon injury of DSS-induced ulcerative colitis mice, effectively relieves weight loss, diarrhea, bloody stool and intestinal mucosa ulcer symptoms caused by colitis, relieves intestinal inflammation and oxidative stress level of the mice, and plays a role in regulating and controlling expression of protein in an NF-kB signal channel. The flaxseed active polypeptide has a remarkable prevention and treatment effect, is simple in preparation method, high in safety and easily available in raw materials, and has a good application prospect in the aspect of development of functional food, special diet or medicine for colitis.

Description

technical field [0001] The invention relates to the application of linseed active polypeptide in the preparation of products for preventing, intervening / treating colitis, and belongs to the technical field of food or medicine. Background technique [0002] Inflammatory bowel disease (IBD) is a recurrent non-specific intestinal inflammatory disease, mainly including ulcerative colitis and colonic Crohn's disease. The pathogenesis is still not completely clear due to the influence of multiple factors such as genetics and environment. IBD can cause intestinal mucosal damage, accompanied by clinical manifestations such as abdominal pain, diarrhea, and blood in the stool, and can easily lead to the occurrence of toxic colitis and colitis-related colon cancer after development. At present, some colitis intervention preparations such as anti-inflammatory drugs, immunosuppressants, and glucocorticoids have achieved certain results in the prevention and control of IBD. However, the...

Claims

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Application Information

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IPC IPC(8): C12P21/06C07K1/34C07K1/14A61K38/01A61P1/00A61P1/04A23L33/18
CPCC12P21/06C07K1/34C07K1/14A61K38/011A61P1/00A61P1/04A23L33/18A23V2002/00A23V2200/32
Inventor 李莉蓉洪理杰杨振光韩兴
Owner KUNMING UNIV OF SCI & TECH
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