A kind of batch preparation method of nicotine salt and its application in electronic cigarette

A nicotine salt and batch technology, which is applied in the field of electronic cigarettes, can solve the problems of high cost and inability to realize mass production of nicotine salt, and achieve the effects of reduced irritation, increased satisfaction, and clean and comfortable aftertaste

Active Publication Date: 2022-07-19
CHINA TOBACCO ZHEJIANG IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of existing nicotine salt generally is to mix organic acid and nicotine, stir and react to obtain nicotine salt; Mass production of nicotine salt

Method used

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  • A kind of batch preparation method of nicotine salt and its application in electronic cigarette
  • A kind of batch preparation method of nicotine salt and its application in electronic cigarette

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Step 1) The cigarette powder is placed in a supercritical extraction device for extraction, the extraction medium is propylene glycol, the extraction pressure is 20Mpa, the temperature is 45°C, and the extraction time is 1.5h to obtain;

[0017] Step 2) first-stage molecular distillation, heating temperature 85 ℃, second-stage molecular distillation, heating temperature 100 ℃, tertiary molecular distillation, heating temperature 130 ℃;

[0018] Step 3) Weigh 1kg of Class A tertiary fraction of tobacco powder and place it in a container; Weigh 2kg of ethyl acetate, pour it into the container, and stir evenly; Weigh 0.6kg of water, pour it into the container, and stir it evenly; After stratification, the layers were separated, the lower aqueous phase was removed, and the upper ethyl acetate phase was left;

[0019] Step 4) Add benzoic acid to the ethyl acetate phase, the amount of benzoic acid is 0.862n, and stir well. Weigh 2kg of water, add it to the solution, and stir...

Embodiment 2

[0024] Step 1) The cigarette powder is placed in a supercritical extraction device for extraction, the extraction pressure is 25Mpa, the temperature is 35°C, and the extraction time is 2h to obtain;

[0025] Step 2) first-stage molecular distillation, heating temperature 90 ℃, second-stage molecular distillation, heating temperature 100 ℃, tertiary molecular distillation, heating temperature 130 ℃;

[0026] Step 3) Weigh 1kg of Class A tertiary fraction of tobacco powder and place it in a container; Weigh 2kg of ethyl acetate, pour it into the container, and stir evenly; Weigh 0.6kg of water and 0.01kg of sodium chloride and pour it into the container, Stir well; let stand for 10 minutes, separate the layers after layering, remove the lower water phase, and leave the upper ethyl acetate phase;

[0027] Step 4) Add benzoic acid to the ethyl acetate phase, the amount of benzoic acid is 0.862kg, and stir well. Weigh 2kg of water, add it to the solution, and stir evenly. Let sta...

Embodiment 3

[0029] Step 1) The cigarette powder is placed in a supercritical extraction device for extraction, the extraction pressure is 30Mpa, the temperature is 55°C, and the extraction time is 3h;

[0030] Step 2) first-stage molecular distillation, heating temperature of 100 °C, secondary molecular distillation, heating temperature of 110 °C, third-stage molecular distillation, heating temperature of 150 °C;

[0031] Step 3) Weigh 1kg of Class A tertiary fraction of tobacco powder and place it in a container; Weigh 2kg of ethyl acetate, pour it into the container, and stir evenly; Weigh 0.6kg of water, pour it into the container, and stir it evenly; After stratification, the layers were separated, the lower aqueous phase was removed, and the upper ethyl acetate phase was left;

[0032] Step 4) Add benzoic acid to the ethyl acetate phase, the amount of benzoic acid is 0.862kg, and stir well. Weigh 2kg of water, add it to the solution, and stir evenly. Let stand for 10 minutes, separ...

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Abstract

The invention provides a batch preparation method of nicotine salt, which comprises: step 1) placing cigarette powder in a supercritical extraction device for extraction, the extraction pressure is 20-30Mpa, the temperature is 35-55°C, and the extraction time is 1.5~4h preparation; step 2) first-stage molecular distillation, heating temperature 85-100 ℃, second-stage molecular distillation, heating temperature 100-110 ℃, tertiary molecular distillation, heating temperature 130-150 ℃; step 3) weighing The tertiary fraction of tobacco powder is placed in a container; ethyl acetate is weighed, poured into the container, and stirred evenly; water is weighed and poured into the container, and stirred evenly; Ethyl acetate phase; Step 4) Add benzoic acid to the ethyl acetate phase, stir well; weigh water, add it to the solution, stir well; let stand, separate the layers after layering, remove the upper ethyl acetate phase, and leave the layer Water phase; the water phase was dehydrated completely by rotary evaporation.

Description

technical field [0001] The invention relates to the field of electronic cigarettes, in particular to a batch preparation method of nicotine salt and its application in electronic cigarettes. Background technique [0002] Nicotine can exist in the form of aprotic state (I) (free state), single proton state (II) or double proton state (III) (bound state, namely nicotine salt), and the nicotine in tobacco can follow the smoke when smoking. The transfer of gas from tobacco to smokers makes the autonomic nervous system and the central nervous system feel the stimulating effect. [0003] The existing preparation methods of nicotine salts are generally to mix organic acid and nicotine, stir and react to obtain nicotine salts; for example, the preparation methods of nicotine salts disclosed by CN107536099A and CN109288115A all require nicotine as a raw material, and the cost is high and cannot be realized. Bulk production of nicotine salts. SUMMARY OF THE INVENTION [0004] One ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A24B15/24A24B15/30A24F40/00
CPCA24B15/243A24B15/30A24F47/00A24F40/00
Inventor 周国俊胡安福储国海吴键汪华文夏倩肖卫强陶丰焦洋唐恒杰
Owner CHINA TOBACCO ZHEJIANG IND
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