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Fingerprint spectrum construction and preparation method of compound pearl detoxification oral liquid

A fingerprint and oral liquid technology, which is applied in the field of establishing the fingerprint method of compound pearl detox oral liquid, can solve the problems of incompleteness, difficulty in quality control and evaluation, and difficulty in the inherent quality of compound pearl detox oral liquid, and achieve objective quality Effect

Pending Publication Date: 2021-07-20
GUANGXI HEBABIZ PHARM TECH CO LTD
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Problems solved by technology

[0003] As a compound preparation of traditional Chinese medicine, compound pearl detoxification oral liquid contains many kinds of traditional Chinese medicines and chemical components, and there are certain difficulties in quality control and evaluation.
According to the existing implementation standard is the State Drug Administration Standard (Trial) (ws-5267 (B-0267)-2017Z), which only uses thin-layer chromatography to detect the three kinds of chlorogenic acid, liquiritin and astilbin. The identification of chemical components and the use of high performance liquid chromatography to detect the content of only one chemical component of chlorogenic acid as the quality control standard of the compound pearl detoxification oral liquid ignore the synergy between the various types and components of the traditional Chinese medicine compound pearl detoxification oral liquid function, it is impossible to comprehensively, accurately and objectively evaluate the quality of compound pearl detoxification oral liquid, and it is difficult to truly reflect the intrinsic quality of compound pearl detoxification oral liquid

Method used

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  • Fingerprint spectrum construction and preparation method of compound pearl detoxification oral liquid
  • Fingerprint spectrum construction and preparation method of compound pearl detoxification oral liquid
  • Fingerprint spectrum construction and preparation method of compound pearl detoxification oral liquid

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Embodiment Construction

[0045] An example of establishing a fingerprint method for compound pearl detoxification oral liquid by using high performance liquid chromatography.

[0046] 1. Instruments and reagents

[0047]Instruments: Agilent 1260 infinit Ⅱ high performance liquid chromatography (Agilent Technologies (China) Co., Ltd.), Shimadzu LC20A high performance liquid chromatography (Shimadzu Enterprise Management) (China) Co., Ltd.), KQ-500DA CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.), SHB-IV double-A circulating water multi-purpose vacuum pump (Zhengzhou Great Wall Science and Industry Trade Co., Ltd.), GH-202 analytical balance (A&D Company, Limited)

[0048] Reagents: methanol, phosphoric acid, ethanol, hydrochloric acid, etc. were of analytical grade; acetonitrile and methanol were of chromatographic grade, purchased from Thermo Fisher Scientific China Co., Ltd.; purified water, purchased from Hangzhou Wahaha Group Co., Ltd.; Acid reference substance (batch number 1107...

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Abstract

A method comprises the following steps: preparing a test solution from a compound pearl detoxification oral liquid, preparing a reference solution, taking an acetonitrile-0. 2% phosphoric acid aqueous solution as a mobile phase system, respectively injecting the test and reference solutions into a high performance liquid chromatograph for determination, and introducing an obtained chromatogram into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system for analysis to obtain the fingerprint spectrum (as shown in the figure 5 in the specification) of the compound pearl detoxification oral liquid. The fingerprint spectrum method of the compound pearl detoxification oral liquid has the characteristics of high precision, good stability, good repeatability and the like, can better reflect the quality information of the compound pearl detoxification oral liquid, can comprehensively control the quality of the compound pearl detoxification oral liquid, and ensures the stability and uniformity of the product.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, and in particular relates to the establishment of a fingerprint method for compound pearl detoxification oral liquid. Background technique [0002] Compound pearl detoxification oral liquid is a traditional Chinese medicine compound preparation made of six medicinal materials such as pearl layer powder, honeysuckle, Smilax cocos, rehmannia glutinosa, licorice, and tortoise shell. It has the functions of clearing away heat and cooling blood, nourishing yin and detoxifying. It is suitable for mild acne caused by heat, toxin and blood stasis on the skin. [0003] As a compound preparation of traditional Chinese medicine, compound pearl detoxification oral liquid contains many kinds of traditional Chinese medicines and chemical components, and there are certain difficulties in quality control and evaluation. According to the existing implementation standard is the State Drug Administration Sta...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/8686G01N2030/027
Inventor 周詹姆斯程林友苏加乐苏岳兰张纲陈建雄钟庆坤
Owner GUANGXI HEBABIZ PHARM TECH CO LTD
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