Fingerprint spectrum construction and preparation method of compound pearl detoxification oral liquid

Abstract

A method comprises the following steps: preparing a test solution from a compound pearl detoxification oral liquid, preparing a reference solution, taking an acetonitrile-0. 2% phosphoric acid aqueous solution as a mobile phase system, respectively injecting the test and reference solutions into a high performance liquid chromatograph for determination, and introducing an obtained chromatogram into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system for analysis to obtain the fingerprint spectrum (as shown in the figure 5 in the specification) of the compound pearl detoxification oral liquid. The fingerprint spectrum method of the compound pearl detoxification oral liquid has the characteristics of high precision, good stability, good repeatability and the like, can better reflect the quality information of the compound pearl detoxification oral liquid, can comprehensively control the quality of the compound pearl detoxification oral liquid, and ensures the stability and uniformity of the product.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, and in particular relates to the establishment of a fingerprint method for compound pearl detoxification oral liquid. Background technique [0002] Compound pearl detoxification oral liquid is a traditional Chinese medicine compound preparation made of six medicinal materials such as pearl layer powder, honeysuckle, Smilax cocos, rehmannia glutinosa, licorice, and tortoise shell. It has the functions of clearing away heat and cooling blood, nourishing yin and detoxifying. It is suitable for mild acne caused by heat, toxin and blood stasis on the skin. [0003] As a compound preparation of traditional Chinese medicine, compound pearl detoxification oral liquid contains many kinds of traditional Chinese medicines and chemical components, and there are certain difficulties in quality control and evaluation. According to the existing implementation standard is the State Drug Administration Sta...

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Problems solved by technology

[0003] As a compound preparation of traditional Chinese medicine, compound pearl detoxification oral liquid contains many kinds of traditional Chinese medicines and chemical components, and there are certain difficulties in quality control and evaluation.

According to the existing implementation standard is the State Drug Administration Standard (Trial) (ws-5267 (B-0267)-2017Z), which only uses thin-layer chromatography to detect the three kinds of chlorogenic acid, liquiritin and astilbin. The identification of chemical components and the use of high perfor

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