Preparation process of pebiprofen
A technology for the preparation of pebiprofen and its preparation technology is applied in the field of preparation technology of pebiprofen to achieve the effects of high reaction yield, mild conditions and easy post-treatment
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0030] Embodiment 1: a kind of preparation technology of pebiprofen comprises the following steps:
[0031] Step 1: Preparation of methyl 2-(4-bromomethylphenyl)propionate
[0032] Dissolve 2-(4-bromomethylphenyl)propionic acid (32g) in toluene (100ml) solution, add methanol (38g) and concentrated sulfuric acid (17g) successively, and react at 30°C for 5 hours under temperature control, and the reaction is complete , cooling and layering, the organic phase was washed with alkali, washed with water, dried and then concentrated under reduced pressure to obtain 33.4g of the compound 2-(4-bromomethylphenyl)methyl propionate, an orange-yellow transparent oily liquid with a purity of more than 98%.
[0033] Step 2: Preparation of methyl 2-(4-formylphenyl)propionate
[0034] Add 24.5g of hexamethylenetetramine and 50ml of water into the reaction flask, stir to dissolve, add 30g of methyl 2-(4-bromomethylphenyl) propionate and 220ml of ethanol, heat and reflux for 5 hours; add 45ml o...
Embodiment 2
[0040] Embodiment 2: a kind of preparation technology of pebiprofen comprises the following steps:
[0041] Step 1: Preparation of methyl 2-(4-bromomethylphenyl)propionate
[0042]Dissolve 2-(4-bromomethylphenyl)propionic acid (32g) in toluene (100ml) solution, add methanol (38g) and concentrated sulfuric acid (17g) successively, and react at 20°C for 8 hours under temperature control, and the reaction is complete , cooling and layering, the organic phase was washed with alkali, washed with water, dried, and then concentrated under reduced pressure to obtain 30.3 g of the compound 2-(4-bromomethylphenyl) methyl propionate, an orange-yellow transparent oily liquid with a purity of more than 98%.
[0043] Step 2: Preparation of methyl 2-(4-formylphenyl)propionate
[0044] Add 24.5g of hexamethylenetetramine and 50ml of water into the reaction flask, stir to dissolve, add 30g of methyl 2-(4-bromomethylphenyl) propionate and 200ml of ethanol, heat and reflux for 3 hours; add 45ml...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com