33 results about "Phenylpropanoic acid" patented technology

The invention discloses a cistanche deserticola extract for improving bone mineral density, the total content of echinacoside and verbascoside in the cistanche deserticola extract is greater than 25wt%, and the cistanche deserticola extract is obtained by adding distilled water into cistanche tubulosa coarse powder for extraction, filtration, filtrate centrifugation, concentration, extraction, concentration and impurity removal, dilution, after-treatment, concentration and drying. The total content of echinacoside and verbascoside in the cistanche deserticola extract for improving the bone mineral density is 25-30 wt%, and the cistanche deserticola extract is rich in shikimic acid, phenylpropionic acid and alkaloid components, so that the cistanche deserticola extract can stably play a role in improving the bone mineral density.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

The present invention provides a phenylpropionic acid derivative, a preparation method, an antioxidant, and applications thereof, belonging to the fields of medicine, health, and the food industry. The phenylpropionic acid derivative is ethane-1,2-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propanoate). The present invention provides a new use for a phenylpropionic acid derivative. In vitro tests have confirmed that the phenylpropionic acid derivative provided by the present invention has good in vitro antioxidant activity and can be used as an active ingredient in an antioxidant, thus having a wide range of applications.

The present disclosure relates to a method for synthesizing a substituted phenylpropionic acid derivative. Specifically, the present disclosure relates to a method for preparing a compound as represented by formula I or a pharmaceutically acceptable salt thereof, which method exhibits a good yield.

The present application provides a compound as shown in the following formula I-1, a tautomer thereof or a pharmaceutically acceptable salt thereof, and application thereof as a GPR40 agonist.

The invention discloses application of phenylpropionic acid as a PPAR-gamma agonist in preparation of a product for preventing, relieving and / or treating enteritis, relates to the technical field of medicines, and solves the problems that the existing medicines are poor in curative effect and do not have dual effects of preventing and relieving enteritis at the same time. Phenylpropionic acid is used as a PPAR-gamma agonist, can reduce infiltration of inflammatory cells into intestinal tissues by activating PPAR-gamma receptors and inhibiting expression of adhesion molecules, and can also regulate functions of immune cells, reduce release of inflammatory mediators, remarkably reduce generation of proinflammatory cytokines and effectively relieve intestinal inflammatory response, so that the intestinal inflammatory response is reduced, and the intestinal inflammatory response is reduced. Therefore, immune-mediated intestinal injury is relieved, immune response is adjusted, and the anti-inflammatory effect is remarkable; by inhibiting the expression of a fibrosis promoting factor, the process of intestinal fibrosis is slowed down or reversed, and complications such as intestinal stenosis are prevented.

The invention discloses a high-cold-resistant flame-retardant cable and a preparation method thereof, and relates to the technical field of cables. According to the invention, 3-(3-tert-butyl-4-hydroxy) methyl phenylpropionate and N-butyl-2, 2, 6, 6-tetramethyl-4-piperidylamine are used as raw materials to form a main anti-aging agent integrating light stability and oxidation resistance, and modified porous carbon is used as a carrier to promote the slow release property of the anti-aging agent, that is, the anti-aging agent is slowly released from gaps under the action of heat, oxygen, light and a solvent, so that the anti-aging effect of the anti-aging agent is improved. Groups on the surface of the porous carbon material can improve the bonding force between polypropylene and the interface of the polypropylene, so that the two-phase interface bonding is tighter, oxygen is prevented from freely diffusing from the surface to the inside, and the anti-aging performance of the cable sheath layer is further improved; and the cold-resistant, flame-retardant and anti-aging performances of the cable sheath layer are greatly improved.

The present application relates to a method for preparing a thermoplastic molding composition based on an ABS copolymer, in which two or more compounds selected from the group consisting of A2: octadecyl 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate; a3: phenylpropionic acid, 3, 5-bis (1, 1-dimethylethyl)-4-hydroxy-, 1, 1 '-(thiodi-2, 1-ethylidene) ester, and A5: 4, 5-bis (1, 1-dimethylethyl)-4-hydroxy-, 1, 1'-(thiodi-2, 1-ethylidene) ester; and A4: a phenolic stabilizer A of 2, 4, 6-tri (3 ', 5'-di-tert-butyl-4 '-hydroxybenzyl) mesitylene, and a thio-co-stabilizer B. The invention further discloses a preparation method of the stabilizer. The ABS molding composition obtained by the method provided by the invention has good color stability.

The invention belongs to the technical field of preparation of organic framework materials, and particularly relates to a magnetic covalent organic framework material as well as a preparation method and application thereof. The magnetic covalent organic framework material is spherical particles and comprises Fe3O4 and COF, the COF wraps the Fe3O4 nanoparticles to form a shell layer, and the shell layer formed by the COF is obtained by connecting a first construction monomer and a second construction monomer through a covalent bond. The magnetic covalent organic framework material has strong adsorption capacity on ester compounds such as ethyl benzoate, ethyl phenylacetate, phenethyl acetate or ethyl phenylpropionate, and the maximum adsorption capacity can be 55.56 mg / g, 52.63 mg / g, 56.18 mg / g and 58.82 mg / g respectively.

The invention relates to the technical field of chinlon, in particular to a plant-source composite anti-ultraviolet functional chinlon filament and a preparation method thereof, and the plant-source composite anti-ultraviolet functional chinlon filament comprises the following raw materials: nylon 6, a functionalized lignin compound, tetra [beta-(3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid) propyl] pentaerythritol ester and polyvinylpyrrolidone. According to the invention, furan groups are introduced into the lignin, so that the polar structure of the lignin can be effectively adjusted, the dispersion stability of the lignin in an organic phase system is improved, the lignin and polyamide molecules can form hydrogen bonds and pi-pi interaction, the interface bonding force and compatibility are remarkably enhanced, and the spinning defect caused by agglomeration of traditional lignin is avoided; the conjugated double bond in the furan ring and the aromatic skeleton of the lignin have a synergistic effect, so that ultraviolet radiation energy can be shielded, and non-radiation dissipation can be realized, thereby inhibiting the photooxidation fracture of the chinlon molecular chain and improving the ultraviolet aging resistance of the filament.

The invention relates to the field of biological medicine, in particular to oligonucleotide with modified nucleotide residues at the 5'terminal and application of the oligonucleotide. The invention provides a uracil derivative which is uracil modified by an aromatic compound, and the aromatic compound is selected from thiophene, pyridine or phenylpropionic acid. The invention provides an oligonucleotide, the 5'terminal of the oligonucleotide is a residue with a modified basic group, and the modification is selected from thiophene modification, pyridine modification or phenylpropionic acid modification. The invention also provides an oligonucleotide conjugate and a pharmaceutical composition related to the oligonucleotide, and application of the oligonucleotide conjugate and the pharmaceutical composition in preparation of nucleic acid drugs. Specific structural modification is carried out on the 5'tail end of oligonucleotide, so that the affinity of oligonucleotide and AGO2 is improved, the silencing efficiency of a drug on a target gene is improved, and diseases and symptoms related to the expression level of the target gene can be prevented and treated.

The application discloses application of a phenylpropionic acid compound in detection of monosaccharide composition of traditional Chinese medicine polysaccharide. The phenylpropionic acid compound has a structure as shown in formula (I). The application provides a new application of the phenylpropionic acid compound, and preliminary realization of quality control research on traditional Chinese medicine preknowing polysaccharide. Compared with a method for detecting monosaccharide composition of traditional Chinese medicine polysaccharide by using 1-phenyl-3-methyl-5-pyrazolone as a pre-column derivatization reagent, the application has the following advantages: 1. Derivatization of aldehyde sugar and ketose can be simultaneously realized; 2. The reaction temperature is more moderate, and the safety of the reaction is greatly improved; 3. The detection wavelength of HPLC-UV is improved from 245 nm to 274 nm, interference is reduced, and sensitivity is improved; and 4. The pre-column derivatization reagent is low in cost and easy to obtain.

The present application relates to a salt-tolerant microorganism Jejubacter sp. and its application, and belongs to the technical field of microorganisms. The Jejubacter sp. DT01 has a preservation number of CGMCC No. 26777. The Jejubacter sp. DT01 can grow normally under the conditions of high salt concentration (0-150 g / L) and high phenolic compound concentration (0-1000 mg / L), and has substrate diversity. In addition to the ordinary carbon sources such as glucose, fructose and the like which can be directly utilized, the Jejubacter sp. DT01 can not only decompose phenolic compounds such as m-hydroxyphenylpropionic acid, phenylpropionic acid, cinnamic acid, ferulic acid, benzoic acid and p-hydroxybenzoic acid, but also can utilize the above-mentioned phenolic compounds as the sole carbon source for growth.

This application relates to the use of hydroxyphenylpropanoate compounds of formula (I), (II), (III), (IV), or (V), or pharmaceutically acceptable salts, solvates, and / or ester prodrugs thereof, compositions comprising the same, and their use in, for example, cancer immunotherapy, for increasing antitumor immunity. More particularly, this application relates to compounds useful in the treatment of diseases, disorders, or conditions that can be treated by increasing intracellular antitumor immunity, such as cancer.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a novel Pichia manshurica strain as well as a microbial agent and application thereof. In order to develop more pichia pastoris new strains and enrich microbial resources in fermented food, a pichia pastoris new strain 2J17 is separated, screened and identified from Maotai-flavor fermented grains, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.39013. The strain not only can grow under high acidity, but also can generate a plurality of volatile aroma compounds, such as ethyl phenylpropionate, ethyl caprylate, isopropyl phenylpropionate, 2-methylbutyric acid-2-phenethyl ester, amyl-gamma-butyrolactone and the like. Therefore, when the strain is applied to fermented food, the flavor of the product can be more prominent, the flower and fruit fragrance and the nut fragrance can be provided at the same time, and the strain has important practical significance for improving the flavor of the fermented food, especially white spirit in production.

This invention discloses an antibacterial spinning oil suitable for acetate fibers used in cigarette filters, comprising an emulsifier, mineral oil, water, and an antibacterial agent. Before phase inversion, it is a transparent water-in-oil liquid; after phase inversion, it becomes a white oil-in-water emulsion. Phase inversion occurs in water or water containing the antibacterial agent. The mass ratio of the spinning oil to the water used for phase inversion or water containing the antibacterial agent before phase inversion is (1–49):(99–51). The antibacterial agent is a commercially available water-soluble antibacterial agent, selected from one or more of the following: 4-chloro-3-cresol, dichlorophenoxychlorophenol, bromochlorobisphenol, benzyl chloroethylammonium, benzalkonium chloride, dodecyl dimethyl ethylphenoxyethyl ammonium bromide, guanidine and guanidine polymers, quaternary ammonium salts, silver ions, copper ions, sodium phenylpropionate, nifedipine, dimethyl fumarate, sorbic acid, and dehydroacetic acid. The concentration of the antibacterial agent in water is 0.1 wt%–100 wt%.

The invention mainly relates to a synthesis method of 1-indanone and derivatives thereof under a ternary composite catalytic system, which comprises the following steps: by taking phenylpropionic acid or derivatives thereof as raw materials, methanesulfonic acid as a basic catalyst, phosphorus pentoxide as a water absorbent and amino acid substances as an accelerant, synthesizing 1-indanone and derivatives thereof under the ternary composite catalytic system; the raw materials are wide in source, the reaction system is simple, no organic solvent is needed, only water serves as a by-product, and compared with a traditional synthesis route with acyl chloride as a substrate, the method has the obvious advantage in the aspect of environmental protection. Therefore, the production cost can be greatly saved in the aspects of raw material cost, equipment corrosion prevention, product separation, three-waste treatment and the like, the method is particularly suitable for industrial amplification, and a brand-new, more environment-friendly and economic synthesis way is provided for large-scale production of indanone compounds.

This invention discloses a method for preparing a high-temperature resistant modified nylon 66 composite fiber material, relating to the field of nylon technology. The method includes the steps of preparing a composite reinforcing antioxidant component, preparing modified nano-silica, and obtaining the composite fiber material. The raw materials used to prepare the composite reinforcing antioxidant component include maleic anhydride-grafted polyolefin elastomer, 1,6-hexanediamine, processing stabilizer, 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid, and p-toluenesulfonic acid. The raw materials used to prepare the modified nano-silica include nano-silica and a composite silane coupling agent. The raw materials used to obtain the composite fiber material include nylon 66 resin, the composite reinforcing antioxidant component, modified nano-silica, pentaerythritol stearate, epoxy resin, and a composite antioxidant additive. The nylon 66 composite fiber material prepared by this invention exhibits strong high-temperature resistance, excellent mechanical properties, and superior aging resistance.

The invention discloses a method for preparing a dihydrofuran-containing compound by using alpha-halogenated ester, which comprises the following steps of: adding 2-chloro-3-oxo-3-methyl phenylpropionate, 1, 1-disubstituted ethylene, N-methylindole, alkali and lewis acid into an organic solvent, reacting at room temperature under the irradiation of blue light, and then performing chromatography to obtain the dihydrofuran-containing compound. According to the method, methyl 2-chloro-3-oxo-3-phenylpropionate, 1, 1-disubstituted ethylene and N-methylindole are used as reactants, and the dihydrofuran-containing compound is obtained through one-step reaction under room-temperature blue light irradiation. The synthesis method has the advantages of high efficiency, simple conditions, high yield and environmental friendliness, and the target molecule has important application value in the fields of medicines and pesticides.

The present disclosure provides an additive for a spunbond nonwoven geotextile and a geotextile. The additive for a spunbond nonwoven geotextile includes titanium dioxide, tris(2,4- di-tert-butylphenyl)phosphite, tetrakis (3,5-di-tert-butyl-4-hydroxy) phenylpropanoic acid pentaerythritol ester, N,N'-ethylenebis(stearamide), zinc stearate, and hard acid ester. The additive can be added during a process of preparing a geotextile with polyethylene terephthalate. The additive can effectively improve the aging resistance of a light-weight geotextile fabric. When the existing geotextiles are used in a construction process, it is necessary to take activity-maintaining measures such as covering and light avoiding. When used outdoors, the geotextile prepared by the present disclosure does not require light-avoiding protection measures, which saves a lot of manpower, materials, and financial resources. 20 24 22 01 08 26 S ep 2 02 4 A B S T R A C T T h e p r e s e n t d i s c l o s u r e p r o v i d e s a n a d d i t i v e f o r a s p u n b o n d n o n w o v e n g e o t e x t i l e a n d a g e o t e x t i l e . T h e a d d i t i v e f o r a s p u n b o n d n o n w o v e n g e o t e x t i l e i n c l u d e s t i t a n i u m d i o x i d e , t r i s ( 2 , 4 - S e p 2 0 2 4 2 2 0 1 0 8 2 6 2 0 2 4 d i - t e r t - b u t y l p h e n y l ) p h o s p h i t e , t e t r a k i s ( 3 , 5 - d i - t e r t - b u t y l - 4 - h y d r o x y ) p h e n y l p r o p a n o i c a c i d p e n t a e r y t h r i t o l e s t e r , N , N ' - e t h y l e n e b i s ( s t e a r a m i d e ) , z i n c s t e a r a t e , a n d h a r d a c i d e s t e r . T h e a d d i t i v e c a n b e a d d e d d u r i n g a p r o c e s s o f p r e p a r i n g a g e o t e x t i l e w i t h p o l y e t h y l e n e t e r e p h t h a l a t e . T h e a d d i t i v e c a n e f f e c t i v e l y i m p r o v e t h e a g i n g r e s i s t a n c e o f a l i g h t - w e i g h t g e o t e x t i l e f a b r i c . W h e n t h e e x i s t i n g g e o t e x t i l e s a r e u s e d i n a c o n s t r u c t i o n p r o c e s s , i t i s n e c e s s a r y t o t a k e a c t i v i t y - m a i n t a i n i n g m e a s u r e s s u c h a s c o v e r i n g a n d l i g h t a v o i d i n g . W h e n u s e d o u t d o o r s , t h e g e o t e x t i l e p r e p a r e d b y t h e p r e s e n t d i s c l o s u r e d o e s n o t r e q u i r e l i g h t - a v o i d i n g p r o t e c t i o n m e a s u r e s , w h i c h s a v e s a l o t o f m a n p o w e r , m a t e r i a l s , a n d f i n a n c i a l r e s o u r c e s . A B S T R A C T S e p 2 0 2 4 2 2 0 1 0 8 2 6 2 0 2 4

The invention discloses a method for synthesizing a polysubstituted thiophene compound. According to the method, trans-beta-styrene sulfonyl chloride or trans-beta-styrene sulfinic acid sodium salt, or trans-beta-styrene sulfonyl chloride and phenylacetylene, or trans-beta-styrene sulfonyl chloride and ethyl 2-fluoro-3-oxo-3-phenylpropionate are used as raw materials, and are fully reacted under the action of triphenylphosphine and a transition metal catalyst to obtain the 2-fluoro-3-oxo-3-phenylpropionate. The polysubstituted thiophene compound is obtained. The method is simple and convenient to operate, and thiophene compounds with different structures can be obtained by changing different substrates and reaction conditions.

The invention relates to the technical field of daily necessities, in particular to an outdoor anti-aging waterproof insulating adhesive tape. The outdoor anti-aging waterproof insulating adhesive tape comprises a release film layer and an anti-aging waterproof layer, the aging-resistant waterproof layer is prepared from the following raw materials in parts by weight: 20 to 50 parts of 3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid isooctyl ester, 30 to 50 parts of epoxy resin, 15 to 30 parts of polysebacic anhydride, 5 to 12 parts of adhesive, 1 to 4 parts of antioxidant and 10 to 20 parts of aging-resistant filler. According to the invention, the specific anti-aging filler is prepared in the raw materials, so that the adhesive tape has good anti-aging and waterproof performance and also has good viscosity and peel strength, the comprehensive performance of the outdoor anti-aging and waterproof insulating adhesive tape can be remarkably improved, and strict requirements of outdoor application are met.

The invention discloses a preparation method and a preparation method of a tablet for treating rheumatoid arthritis. The tablet is prepared from the following raw materials in parts by weight. The preparation method comprises the following steps: 1, preparing an additive, namely, gram of isobutylphenylpropionic acid, gram of diclofenac, gram of methotrexate, gram of leflunomide, gram of microcrystalline cellulose, gram of lactose, gram of croscarmellose sodium and gram of sodium carboxymethyl starch, and the additive is composed of a lubricant and an adhesive, and the preparation method comprises the following steps: 1, adjusting the formula; b) preparing raw materials; c) processing the raw materials; d) adding materials; step e) packaging treatment; step a) formula adjustment; the formula of the tablet is determined according to the magnitude of rheumatoid arthritis and application requirements. The aryl propionic acid belongs to an ibuprofen non-steroidal anti-inflammatory drug, and the synthesis of prostaglandin is reduced by inhibiting the activity of epoxidase, so that the inflammatory reaction and pain are relieved, the inflammation of rheumatoid arthritis is reduced, and the pain is reduced.

The invention belongs to the technical field of binders for lithium supplementation, and discloses a composite binder for a lithium supplementation agent, a preparation method of the composite binder and a lithium ion battery, the composite binder for the lithium supplementation agent comprises a solvent, polyvinylidene fluoride and an antioxidant additive, and the antioxidant additive is selected from tetra (3, 4-dichlorophenyl)-1, 2, 3, 4-tetrakis (3, 4-dichlorophenyl)-1, 2, 3, 4-tetrakis (3, 4-dichlorophenyl)-1, 2, the preparation method comprises the following steps: adding 2, 5-di-tert-butyl-4-hydroxy) phenylpropionic acid pentaerythritol ester, beta-(3, 5-di-tert-butyl-4-hydroxy phenyl) n-octadecanol propionate, 2, 6-di-tert-butyl-4-methylphenol, 4-[(4, 6-dioctylsulfanyl-1, 3, 5-triazine-2-yl) amino]-2, 6-di-tert-butylphenol, 3-(3, 5-di-tert-butyl-4-hydroxy phenyl)-N '-[3-(3, 5-di-tert-butyl-4-hydroxy phenyl)-1, 3, 5-triazine-2-yl) amino]-2, 6-di-tert-butylphenol, 4-(4, 6-dioctyl sulfenyl-1, 3, 5- the compound is selected from at least one of 2, 5-di-tert-butyl-4-hydroxyphenyl) propionyl] propionyl hydrazine. The anti-oxidation additive can absorb active oxygen generated by the lithium supplement agent and is combined with the active oxygen to inhibit side reaction caused by the active oxygen, so that the formation gas production rate of the lithium supplement battery is effectively reduced, and the problem of high-temperature circulation or storage gas production of the lithium supplement battery is solved.