The invention relates to a synthetic method of novel chemicals, in particular to a preparation method of 2-guanidino phenylpropionic acid. The preparation method comprises the main steps: step one, stirring and mixing
phenylalanine with
purified water, thus forming a
mixed solution; step two, regulating the PH (Potential of
Hydrogen) value of the
mixed solution to be 8 to 10 by using liquid caustic soda; step three, starting to dropwise add
hydrogen cyanamide while rising the temperature of the
mixed solution obtained in the step two to 60 to 80 DEG C; step four, starting to cool to 20 DEG C or less after keeping warm for 2 hours; step five, regulating the PH value of the mixed solution to be 6 to 8 by using
hydrochloric acid; step six, centrifuging,
drying and packaging. The 2-guanidino phenylpropionic acid is a new compound, a small amount of information shows that the 2-guanidino phenylpropionic acid is a derivative of aromatic
amino acid needed by a
human body, and the 2-guanidinophenylpropionic acid has a very important function in the fields of medicinal intermediates, food and feed. According to the preparation method disclosed by the invention, the 2-guanidino phenylpropionic acid is produced by adopting the
phenylalanine, the liquid caustic soda, the
hydrochloric acid and the
hydrogen cyanamide as main raw materials, and the preparation method has the advantages thatthe technology is simple, the reaction is mild, the yield is high, the product purity is high,
greening and environment protection are realized, and the like.