40 results about "Phenylpropanoic acid" patented technology

The invention provides a phenylpropionic acid derivative, a preparation method thereof, an antioxidant and application, and belongs to the field of medicine and health and food industry. The phenylpropionic acid derivative is ethane-1, 2-diyl bis (3-(3, 5-di-tert-butyl-4-hydroxyphenyl)-propanoate, and the structural formula of the phenylpropionic acid derivative is shown in the specification, and the structural formula of the phenylpropionic acid derivative is shown in the specification, namely ethane-1, 2-diyl bis (3-(3, 5-di-tert-butyl-4-hydroxyphenyl)-propanoate. The invention provides a new application of the phenylpropionic acid derivative, and in-vitro tests prove that the phenylpropionic acid derivative provided by the invention has better in-vitro antioxidant activity, can be used as an active component of an antioxidant, and has wide application.

The invention discloses a cistanche deserticola extract for improving bone mineral density, the total content of echinacoside and verbascoside in the cistanche deserticola extract is greater than 25wt%, and the cistanche deserticola extract is obtained by adding distilled water into cistanche tubulosa coarse powder for extraction, filtration, filtrate centrifugation, concentration, extraction, concentration and impurity removal, dilution, after-treatment, concentration and drying. The total content of echinacoside and verbascoside in the cistanche deserticola extract for improving the bone mineral density is 25-30 wt%, and the cistanche deserticola extract is rich in shikimic acid, phenylpropionic acid and alkaloid components, so that the cistanche deserticola extract can stably play a role in improving the bone mineral density.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

The invention belongs to the field of pesticides, and particularly relates to a synthesis method of a pesticide intermediate 2, 6-dimethyl-1-indanone. The preparation method comprises the following steps: 1) in a polar solvent, performing base catalysis on diethyl methylmalonate and p-methyl benzyl halide to obtain diester; (2) catalyzing the diester by strong inorganic acid at a relatively low temperature, and carrying out decarboxylation reaction to obtain phenylpropionic acid; 3) carrying out acyl halogenation on phenylpropionic acid to obtain phenylpropionyl halide; and 4) carrying out Friedel-Crafts reaction on the benzene propionyl halide under the action of a catalyst, and synthesizing to obtain the 2, 6-dimethyl-1-indanone. In the diester synthesis process, the raw materials diethyl methylmalonate and p-methyl benzyl halide react in the polar solvent under the catalysis of alkali, the reaction condition is mild, the reaction temperature can be reduced from 150 DEG C to 40-50 DEG C, the energy consumption in the reaction process is greatly reduced, the intrinsic safety of the process is improved, and the method is suitable for industrial production.

The present invention provides a phenylpropionic acid derivative, a preparation method, an antioxidant, and applications thereof, belonging to the fields of medicine, health, and the food industry. The phenylpropionic acid derivative is ethane-1,2-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propanoate). The present invention provides a new use for a phenylpropionic acid derivative. In vitro tests have confirmed that the phenylpropionic acid derivative provided by the present invention has good in vitro antioxidant activity and can be used as an active ingredient in an antioxidant, thus having a wide range of applications.

The present disclosure relates to a method for synthesizing a substituted phenylpropionic acid derivative. Specifically, the present disclosure relates to a method for preparing a compound as represented by formula I or a pharmaceutically acceptable salt thereof, which method exhibits a good yield.

The present application provides a compound as shown in the following formula I-1, a tautomer thereof or a pharmaceutically acceptable salt thereof, and application thereof as a GPR40 agonist.

The invention discloses application of phenylpropionic acid as a PPAR-gamma agonist in preparation of a product for preventing, relieving and / or treating enteritis, relates to the technical field of medicines, and solves the problems that the existing medicines are poor in curative effect and do not have dual effects of preventing and relieving enteritis at the same time. Phenylpropionic acid is used as a PPAR-gamma agonist, can reduce infiltration of inflammatory cells into intestinal tissues by activating PPAR-gamma receptors and inhibiting expression of adhesion molecules, and can also regulate functions of immune cells, reduce release of inflammatory mediators, remarkably reduce generation of proinflammatory cytokines and effectively relieve intestinal inflammatory response, so that the intestinal inflammatory response is reduced, and the intestinal inflammatory response is reduced. Therefore, immune-mediated intestinal injury is relieved, immune response is adjusted, and the anti-inflammatory effect is remarkable; by inhibiting the expression of a fibrosis promoting factor, the process of intestinal fibrosis is slowed down or reversed, and complications such as intestinal stenosis are prevented.

The invention discloses a method for synthesizing 2-phenylpropionic acid through reaction of styrene and carbon dioxide under the catalysis of nickel, which comprises the following steps: adding styrene, a nickel compound, an organic ligand and manganese into a reactor, reacting with carbon dioxide in an organic solvent medium at a certain temperature and pressure, then adding diluted hydrochloric acid, and stirring at normal temperature to complete the reaction, and extracting the reaction mixed solution with an organic extractant to separate out an organic phase, and carrying out reduced pressure distillation on the organic solvent on the organic phase to obtain 2-phenylpropionic acid. According to the invention, styrene is taken as a raw material, under the action of the nickel compound catalyst, direct carboxylation reaction of styrene and carbon dioxide is effectively realized, and compared with the traditional oxidation, hydrolysis and other multi-step carboxylic acid preparation methods, the method provided by the invention has the advantages of high atom utilization rate, simple technical process and other industrial application sustainable development characteristics; particularly, the atom economy of the synthetic reaction is highlighted by recycling the carbon dioxide.

The invention discloses a high-cold-resistant flame-retardant cable and a preparation method thereof, and relates to the technical field of cables. According to the invention, 3-(3-tert-butyl-4-hydroxy) methyl phenylpropionate and N-butyl-2, 2, 6, 6-tetramethyl-4-piperidylamine are used as raw materials to form a main anti-aging agent integrating light stability and oxidation resistance, and modified porous carbon is used as a carrier to promote the slow release property of the anti-aging agent, that is, the anti-aging agent is slowly released from gaps under the action of heat, oxygen, light and a solvent, so that the anti-aging effect of the anti-aging agent is improved. Groups on the surface of the porous carbon material can improve the bonding force between polypropylene and the interface of the polypropylene, so that the two-phase interface bonding is tighter, oxygen is prevented from freely diffusing from the surface to the inside, and the anti-aging performance of the cable sheath layer is further improved; and the cold-resistant, flame-retardant and anti-aging performances of the cable sheath layer are greatly improved.

A thermoplastic polyurethane precursor, which can be used for preparing thermoplastic polyurethane having low initial chromaticity, high yellowing resistance, high thermal-oxidative aging resistance, high hydrolysis resistance, and a low crystal point. The thermoplastic polyurethane precursor comprises polyisocyanate, a chain extender, a polymer polyol, and a first auxiliary agent, wherein the first auxiliary agent comprises: (d1) phenylpropionic acid-3,5-bis(1,1-dimethylethyl)-4-hydroxy-C7-C9 branched alkyl ester; (d2) phosphorous acid mixed with 2,4-bis(1,1-dimethylpropyl)phenyl and 4-(1,1-dimethylpropyl)phenyl triester; (d3) 4-tert-butyl-2-(5-tert-butyl-2-oxo-3H-benzofuran-3-yl)phenyl-3,5-di-tert-butyl-4-hydroxybenzoate; and (d4) at least one of a compound of formula (I) and a compound of formula (II), wherein R1 is C12 alkenyl.

Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producinges, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.

The present application relates to a method for preparing a thermoplastic molding composition based on an ABS copolymer, in which two or more compounds selected from the group consisting of A2: octadecyl 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate; a3: phenylpropionic acid, 3, 5-bis (1, 1-dimethylethyl)-4-hydroxy-, 1, 1 '-(thiodi-2, 1-ethylidene) ester, and A5: 4, 5-bis (1, 1-dimethylethyl)-4-hydroxy-, 1, 1'-(thiodi-2, 1-ethylidene) ester; and A4: a phenolic stabilizer A of 2, 4, 6-tri (3 ', 5'-di-tert-butyl-4 '-hydroxybenzyl) mesitylene, and a thio-co-stabilizer B. The invention further discloses a preparation method of the stabilizer. The ABS molding composition obtained by the method provided by the invention has good color stability.

The invention belongs to the technical field of preparation of organic framework materials, and particularly relates to a magnetic covalent organic framework material as well as a preparation method and application thereof. The magnetic covalent organic framework material is spherical particles and comprises Fe3O4 and COF, the COF wraps the Fe3O4 nanoparticles to form a shell layer, and the shell layer formed by the COF is obtained by connecting a first construction monomer and a second construction monomer through a covalent bond. The magnetic covalent organic framework material has strong adsorption capacity on ester compounds such as ethyl benzoate, ethyl phenylacetate, phenethyl acetate or ethyl phenylpropionate, and the maximum adsorption capacity can be 55.56 mg / g, 52.63 mg / g, 56.18 mg / g and 58.82 mg / g respectively.

The invention relates to the technical field of chinlon, in particular to a plant-source composite anti-ultraviolet functional chinlon filament and a preparation method thereof, and the plant-source composite anti-ultraviolet functional chinlon filament comprises the following raw materials: nylon 6, a functionalized lignin compound, tetra [beta-(3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid) propyl] pentaerythritol ester and polyvinylpyrrolidone. According to the invention, furan groups are introduced into the lignin, so that the polar structure of the lignin can be effectively adjusted, the dispersion stability of the lignin in an organic phase system is improved, the lignin and polyamide molecules can form hydrogen bonds and pi-pi interaction, the interface bonding force and compatibility are remarkably enhanced, and the spinning defect caused by agglomeration of traditional lignin is avoided; the conjugated double bond in the furan ring and the aromatic skeleton of the lignin have a synergistic effect, so that ultraviolet radiation energy can be shielded, and non-radiation dissipation can be realized, thereby inhibiting the photooxidation fracture of the chinlon molecular chain and improving the ultraviolet aging resistance of the filament.

The invention relates to the field of biological medicine, in particular to oligonucleotide with modified nucleotide residues at the 5'terminal and application of the oligonucleotide. The invention provides a uracil derivative which is uracil modified by an aromatic compound, and the aromatic compound is selected from thiophene, pyridine or phenylpropionic acid. The invention provides an oligonucleotide, the 5'terminal of the oligonucleotide is a residue with a modified basic group, and the modification is selected from thiophene modification, pyridine modification or phenylpropionic acid modification. The invention also provides an oligonucleotide conjugate and a pharmaceutical composition related to the oligonucleotide, and application of the oligonucleotide conjugate and the pharmaceutical composition in preparation of nucleic acid drugs. Specific structural modification is carried out on the 5'tail end of oligonucleotide, so that the affinity of oligonucleotide and AGO2 is improved, the silencing efficiency of a drug on a target gene is improved, and diseases and symptoms related to the expression level of the target gene can be prevented and treated.

The application discloses application of a phenylpropionic acid compound in detection of monosaccharide composition of traditional Chinese medicine polysaccharide. The phenylpropionic acid compound has a structure as shown in formula (I). The application provides a new application of the phenylpropionic acid compound, and preliminary realization of quality control research on traditional Chinese medicine preknowing polysaccharide. Compared with a method for detecting monosaccharide composition of traditional Chinese medicine polysaccharide by using 1-phenyl-3-methyl-5-pyrazolone as a pre-column derivatization reagent, the application has the following advantages: 1. Derivatization of aldehyde sugar and ketose can be simultaneously realized; 2. The reaction temperature is more moderate, and the safety of the reaction is greatly improved; 3. The detection wavelength of HPLC-UV is improved from 245 nm to 274 nm, interference is reduced, and sensitivity is improved; and 4. The pre-column derivatization reagent is low in cost and easy to obtain.

The present application relates to a salt-tolerant microorganism Jejubacter sp. and its application, and belongs to the technical field of microorganisms. The Jejubacter sp. DT01 has a preservation number of CGMCC No. 26777. The Jejubacter sp. DT01 can grow normally under the conditions of high salt concentration (0-150 g / L) and high phenolic compound concentration (0-1000 mg / L), and has substrate diversity. In addition to the ordinary carbon sources such as glucose, fructose and the like which can be directly utilized, the Jejubacter sp. DT01 can not only decompose phenolic compounds such as m-hydroxyphenylpropionic acid, phenylpropionic acid, cinnamic acid, ferulic acid, benzoic acid and p-hydroxybenzoic acid, but also can utilize the above-mentioned phenolic compounds as the sole carbon source for growth.

This application relates to the use of hydroxyphenylpropanoate compounds of formula (I), (II), (III), (IV), or (V), or pharmaceutically acceptable salts, solvates, and / or ester prodrugs thereof, compositions comprising the same, and their use in, for example, cancer immunotherapy, for increasing antitumor immunity. More particularly, this application relates to compounds useful in the treatment of diseases, disorders, or conditions that can be treated by increasing intracellular antitumor immunity, such as cancer.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a novel Pichia manshurica strain as well as a microbial agent and application thereof. In order to develop more pichia pastoris new strains and enrich microbial resources in fermented food, a pichia pastoris new strain 2J17 is separated, screened and identified from Maotai-flavor fermented grains, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.39013. The strain not only can grow under high acidity, but also can generate a plurality of volatile aroma compounds, such as ethyl phenylpropionate, ethyl caprylate, isopropyl phenylpropionate, 2-methylbutyric acid-2-phenethyl ester, amyl-gamma-butyrolactone and the like. Therefore, when the strain is applied to fermented food, the flavor of the product can be more prominent, the flower and fruit fragrance and the nut fragrance can be provided at the same time, and the strain has important practical significance for improving the flavor of the fermented food, especially white spirit in production.

This invention discloses an antibacterial spinning oil suitable for acetate fibers used in cigarette filters, comprising an emulsifier, mineral oil, water, and an antibacterial agent. Before phase inversion, it is a transparent water-in-oil liquid; after phase inversion, it becomes a white oil-in-water emulsion. Phase inversion occurs in water or water containing the antibacterial agent. The mass ratio of the spinning oil to the water used for phase inversion or water containing the antibacterial agent before phase inversion is (1–49):(99–51). The antibacterial agent is a commercially available water-soluble antibacterial agent, selected from one or more of the following: 4-chloro-3-cresol, dichlorophenoxychlorophenol, bromochlorobisphenol, benzyl chloroethylammonium, benzalkonium chloride, dodecyl dimethyl ethylphenoxyethyl ammonium bromide, guanidine and guanidine polymers, quaternary ammonium salts, silver ions, copper ions, sodium phenylpropionate, nifedipine, dimethyl fumarate, sorbic acid, and dehydroacetic acid. The concentration of the antibacterial agent in water is 0.1 wt%–100 wt%.

The invention mainly relates to a synthesis method of 1-indanone and derivatives thereof under a ternary composite catalytic system, which comprises the following steps: by taking phenylpropionic acid or derivatives thereof as raw materials, methanesulfonic acid as a basic catalyst, phosphorus pentoxide as a water absorbent and amino acid substances as an accelerant, synthesizing 1-indanone and derivatives thereof under the ternary composite catalytic system; the raw materials are wide in source, the reaction system is simple, no organic solvent is needed, only water serves as a by-product, and compared with a traditional synthesis route with acyl chloride as a substrate, the method has the obvious advantage in the aspect of environmental protection. Therefore, the production cost can be greatly saved in the aspects of raw material cost, equipment corrosion prevention, product separation, three-waste treatment and the like, the method is particularly suitable for industrial amplification, and a brand-new, more environment-friendly and economic synthesis way is provided for large-scale production of indanone compounds.

The invention relates to a thermoplastic polyurethane precursor which can be used for preparing thermoplastic polyurethane with low initial chroma, high yellowing resistance, high thermo-oxidative aging resistance, high hydrolysis resistance and low crystal point. The thermoplastic polyurethane precursor comprises a polyisocyanate, a chain extender, a polymer polyol and a first auxiliary agent, and the first auxiliary agent comprises (d1) phenylpropionic acid-3, 5-bis (1, 1-dimethylethyl)-4-hydroxy-C7-C9 branched alkyl ester, (d2) phenylpropionic acid-3, 5-bis (1, 1-dimethylethyl)-4-hydroxy-C7-C9 branched alkyl ester, (d3) phenylpropionic acid-3, 5-bis (1, 1-dimethylethyl)- (d2) mixing phosphorous acid with 2, 4-bis (1, 1-dimethyl propyl) phenyl and 4-(1, 1-dimethyl propyl) phenyl triester; (d3) 4-tert-butyl-2-(5-tert-butyl-2-oxy-3H-benzofuran-3-yl) phenyl-3, 5-di-tert-butyl-4-hydroxybenzoate, and (d4) 4-tert-butyl-2-(5-tert-butyl-2-oxy-3H-benzofuran-3-yl) And (d4) at least one of a compound of formula (I) and a compound of formula (II) [Formula (I)] # imgabs0 # wherein R1 is a C12 alkenyl group; [Formula (II)] # imgabs1 #

This invention discloses a method for preparing a high-temperature resistant modified nylon 66 composite fiber material, relating to the field of nylon technology. The method includes the steps of preparing a composite reinforcing antioxidant component, preparing modified nano-silica, and obtaining the composite fiber material. The raw materials used to prepare the composite reinforcing antioxidant component include maleic anhydride-grafted polyolefin elastomer, 1,6-hexanediamine, processing stabilizer, 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid, and p-toluenesulfonic acid. The raw materials used to prepare the modified nano-silica include nano-silica and a composite silane coupling agent. The raw materials used to obtain the composite fiber material include nylon 66 resin, the composite reinforcing antioxidant component, modified nano-silica, pentaerythritol stearate, epoxy resin, and a composite antioxidant additive. The nylon 66 composite fiber material prepared by this invention exhibits strong high-temperature resistance, excellent mechanical properties, and superior aging resistance.

The present invention belongs to the technical field of photocatalytic organic chemical synthesis, and relates to a method for continuously preparing isobufenprofen using a microchannel module reaction device. Isobutylbenzene and methyl 2-bromopropionate are dissolved in a solvent to obtain a solution A; a photocatalyst and an alkali are dissolved in a solvent to obtain a solution B; solution A and solution B are respectively and simultaneously pumped into a first microstructure reactor of a microchannel module reaction device for photoreaction to obtain a first reaction liquid; the first reaction liquid obtained and an acidic aqueous solution are respectively and simultaneously pumped into a second microstructure reactor of a microchannel module reaction device for hydrolysis reaction to obtain a second reaction liquid; the second reaction liquid is washed with water, extracted, separated and purified to obtain isobufenprofen. The method for continuously preparing isobufenprofen using a microchannel module reaction device provided by the present invention has high reaction efficiency, low energy consumption, mild reaction conditions, and a safer, more efficient and green reaction process, and has great potential in later industrial applications.

The invention discloses a method for preparing a dihydrofuran-containing compound by using alpha-halogenated ester, which comprises the following steps of: adding 2-chloro-3-oxo-3-methyl phenylpropionate, 1, 1-disubstituted ethylene, N-methylindole, alkali and lewis acid into an organic solvent, reacting at room temperature under the irradiation of blue light, and then performing chromatography to obtain the dihydrofuran-containing compound. According to the method, methyl 2-chloro-3-oxo-3-phenylpropionate, 1, 1-disubstituted ethylene and N-methylindole are used as reactants, and the dihydrofuran-containing compound is obtained through one-step reaction under room-temperature blue light irradiation. The synthesis method has the advantages of high efficiency, simple conditions, high yield and environmental friendliness, and the target molecule has important application value in the fields of medicines and pesticides.