76 results about "Phenylpropanoic acid" patented technology

The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor alpha (PPARalpha), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride).It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1),their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

The invention belongs to the field of microbial fermentation, and especially relates to a fermentation metabolite having an effect of protecting skins, and a preparation method and applications thereof. The product is prepared by taking lactobacillus plantarum, lactobacillus casei, lactobacillus lactentis, bifidobacterium animalis and lactobacillus rhamnosus as fermentation strains and taking sucrose, seaweed meal, soybean meal and milk powder as fermentation raw materials through mixing and fermentation. The product contains specific fermentation metabolites, such as malonylgenistin, genistein, hyaluronic acid, irone, Preaustinoid A and daidzein, which are helpful for the enhancement of a skin protection effect; and tartaric acid, malic acid, succinic acid, salicylic acid, vanillic acid, phenylpropionic acid and other organic acid generated by fermentation can control pathogenic bacteria and spoilage microbial flora, so that skin flora balance can be maintained, and a natural antiseptic effect can be achieved. Efficacy tests show that the product has the efficacy of removing wrinkles, increasing skin elasticity, resisting inflammation and repairing skin barriers, and is significant in effect.

The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and exhibit potent lipid-decreasing action, and processes for preparing them.It relates to substituted phenylpropionic acid derivatives represented by a general formula (1)[wherein R1 denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents, R2 denotes a hydrogen atom, lower alkyl group with carbon atoms of 1 to 4 or lower alkoxy group with carbon atoms of 1 to 3, R3 denotes a lower alkoxy group with carbon atoms of 1 to 3, and the binding mode of A portion denotes —CH2CONH—, —NHCOCH2—, —CH2CH2CO—, —CH2CH2CH2—, —CH2CH2O—, —CONHCH2—, —CH2NHCH2—, —COCH2O—, —OCH2CO—, —COCH2NH— or —CHCH2CO—], their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

The invention discloses a novel thermal-insulation energy-saving material which is composed of the following components in parts by weight: 8-9 parts of expanded perlite, 8-9 parts of ash calcium powder, 1-2 parts of dioctyl phthalate, 6-7 parts of hydroxy polyphosphate, 3-4 parts of polypropylene fiber, 1-2 parts of white clay powder, 1-2 parts of sodium fluosilicate, 3-4 parts of sodium silicate, 1-2 parts of aluminum dihydrogen phosphate, 6-7 parts of fly ash, 1-2 parts of polysulfide rubber and 1-2 parts of isooctyl 3,5-di-tert-butyl-4-hydroxy phenylpropionate. The novel thermal-insulation energy-saving material has favorable effects of heat preservation, sound insulation, thermal insulation and energy saving.

The present invention relates to a kind of pyrimidine substituted phenylpropionic acid derivative compounds of formula I which includes itsgeometric isomer, enantiomer, diastereoisomer, racemate, and mixture therefore or pharmaceutically acceptable salt thereof. The present invention also relates to the preparation method and use of such compound. Compounds of present invention are useful in the treatment of polycystic kidney disease.

This invention relates to a cytotoxic phenylallyl phenylacrylate as shown in formula (1) and its analogs or phenylpropyl phenylpropionate as shown in formula (2), its analogs and its offcinal salts or solvates. This invention also relates to the preparation method for these compounds and the intermediates for preparation. Besides, this invention still relates to the pharmacological use of these compounds and their blended composites. The compounds in this invention have growth inhibitory activity towards tumor cells and are estimated to be used as antineoplastics.

The invention provides a pyrimidine substituted phenylpropionic acid compound shown in formula (I), and application of enantiomer, racemic modification, a pharmaceutically acceptable salt of the compound, or a mixture of the enantiomer, the racemic modification and the pharmaceutically acceptable salt of the compound to preparation of medicine for preventing and / or treating diabetes mellitus. The compound as PPAR-gamma excitant can participate in the regulation of genetic transcription through activating PXR / PPAR heterodimer, thereby effectively treating and / or preventing the diabetes mellitus. The invention also provides a medicine composition which contains the compound and has the effect of preventing and / or treating the diabetes mellitus.

The invention provides a new strain-Saccharomyces cerevisiae CGMCC NO.3361 and application thereof in preparing (R)-(+)-beta-hydroxy-benzenepropanoic acid ethylester by microbial transformation. The Saccharomyces cerevisiae was collected in China General Microbiological Culture Collection Center (CGMCC), the address of which is Institute of Microbiology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101. The collection date is October 23, 2009 and the collection number is CGMCC NO.3361. The beneficial effects of preparing (R)-(+)-beta-hydroxy-benzenepropanoic acid ethylester by the microbial transformation method in the invention are mainly as follows: (1) the biocatalyst is a microbial thallus, thus is lower in cost than the chemical catalysts; (2) the environment is friendly, the reaction conditions are mild and the transformation can be carried out smoothly under normal temperature and normal pressure; (3) the strain used in the production is safe and nontoxic; (4) the method is not influenced by seasons and is easy to realize large-scale industrial production; (5) the production operation is simple and convenient and the biotransformation rate is higher; and (6) coenzyme is unnecessary to be added in the whole reaction process.

The invention belongs to the field of synthesis of drug intermediates, and particularly relates to a preparation method of p-bromomethyl isophenylpropionic acid, which comprises the following steps: A, synthesis of alpha-methyl benzyl chloride: carrying out addition reaction on styrene serving as a raw material and hydrogen chloride gas in an organic solvent to generate alpha-methyl benzyl chloride, B, synthesis of 2-phenylpropionic acid: preparing alpha-methyl benzyl chloride into a Grignard solution through a Grignard reaction, the Grignard solution and carbon dioxide gas are subjected to acarboxylation reaction to generate a carboxylation solution, and the carboxylation solution is hydrolyzed to obtain 2-phenylpropionic acid, and C, synthesis of p-bromomethyl isophenylpropionic acid: carrying out bromomethylation reaction of 2-phenylpropionic acid, hydrobromic acid and polyformaldehyde so that p-bromomethyl isophenylpropionic acid is generated. The preparation method of p-bromomethyl isophenylpropionic acid provided by the invention has the advantages of cheap and accessible raw materials and simple technique, and is suitable for industrial production.

The invention discloses a lubricant for food machinery and a preparation method thereof. The lubricant for food machinery comprises the following components in parts by mass: 50-80 parts of vegetable oil, 5-20 parts of sucrose, 1-8 parts of sodium chloride, 1-2 parts of amino acid, 2-6 parts of sodium aliphatate, 1-3 parts of sorbitol, 1-3 parts of citric acid, 3-8 parts of methyl aspartyl phenylpropionate and 0.5-2.5 parts of emulsifier. The amino acid is leucine or isoleucine. The emulsifier is oil-base amino acid sodium. All the components in the lubricant are food-grade materials which are safe and nontoxic, and the components are precisely proportioned to prepare the lubricant with excellent frictional property.

The invention provides corrosion inhibitor for carbon steel in the oil field acid environment, and particularly relates to preparation and application of low-toxicity and efficient corrosion inhibitor for restraining corrosion of carbon steel and products of the carbon steel in oil field acid pickling liquid or a saturated CO2 medium. According to the preparing method of the corrosion inhibitor, 3-phenylpropionic acid and diethylenetriamine are subjected to the dehydration reaction, and the phenylpropionic acid imidazoline ramification is obtained. According to the product, comprehensive corrosion and local corrosion is prevented from being generated in the process that the carbon steel makes contact with the acid pickling liquid or the CO2 medium. The compound does not serve as metal corrosion inhibitor at current. By adoption of the corrosion inhibitor, production is simple and convenient, toxicity is small, the inhibition rate is high, corrosion damage to the carbon steel from the acid pickling liquid or CO2 can be effectively restrained, and wide application prospects are achieved. The steps are simple, operation is convenient, and practicability is high.

The invention discloses an environment-friendly light brush plate for an urban cleaning vehicle. The brush plate is light in dead weight, high in homogeneity, capable of effectively improving the work efficiency of cleaning equipment and low in production cost. The brush plate is prepared from the following materials in parts by weight: 75-80 parts of a PP regenerated material, 12-18 parts of a PE regenerated material, 2.5-4 parts of modified polypropylene, 0.4-1 part of sodium bicarbonate, 0.4-1 part of azodicarbonamide, 0.05-0.1 part of tetra(3.5-bitertiary butyl-4-hydroxyl) phenylpropionic acid pentaerythritol ester, 0.05-0.1 part of stearic acid, 0.05-0.1 part of paraffin and 1-2 parts of a color master batch. The invention also provides a preparation method of the environment-friendly light brush plate for the urban cleaning vehicle.

The present invention provides a new strain-Saccharomyces cerevisiae CGMCC NO.3361 and application thereof in preparing (R)-(+)-beta-hydroxy-benzenepropanoic acid ethylester by microbial transformation. The Saccharomyces cerevisiae was collected in China General Microbiological Culture Collection Center (CGMCC). The collection date is October 23, 2009 and the collection number is CGMCC NO.3361. The beneficial effects of preparing (R)-(+)-beta-hydroxy-benzenepropanoic acid ethylester by the microbial transformation method in the invention are mainly as follows: (1) the biocatalyst is a microbial thallus, thus is lower in cost than the chemical catalysts; (2) the environment is friendly, the reaction conditions are mild and the transformation can be carried out smoothly under normal temperature and normal pressure; (3) the strain used in the production is safe and nontoxic; (4) the method is not influenced by seasons and is easy to realize large-scale industrial production; (5) the production operation is simple and convenient and the biotransformation rate is higher; and (6) coenzyme is unnecessary to be added in the whole reaction process.

The invention discloses a method for extracting perillaseed hydrophilic chemical components from perillaseed oil residue. The method employs perillaseed oil residue as a raw material to extract hydrophilic chemical components in the perillaseed. The method adopts specific methods including solvent extraction, organic solvent extraction and resin separation and purification. The obtained hydrophilic chemical components mainly comprise flavone, flavone glycosides, phenylpropionic acid, phenpropionate and glycosides such as rosmarinic acid and rosmarinic acid glycoside. Calculated by rosmarinic acid as a representative component, yield of the representative component in the perillaseed oil residue is higher or close to yield of the component in perillaseed; therefore, perillaseed oil residue can be used as a substitute for raw material for preparation of perillaseed hydrophilic component.

The invention discloses a high-load brush disc for a window wiper. The high-load brush disc is characterized by being prepared from the following raw materials in parts by weight: 75 to 80 parts of a PP (Polypropene) reworked material, 12 to 18 parts of a PE (Polyethylene) reworked material, 5 to 14 parts of modified PP, 10 to 20 parts of ammonium trimethyl methyl sulfate, 4 to 10 parts of sodium bicarbonate, 5 to 8 parts of azodicarbonamide, 2 to 6 parts of pentaerythritol phenylpropionate, 30 to 35 parts of fatty alcohol polyoxyethylene ether, 2 to 4 parts of azodiisobutyronitrile, 6 to 8 parts of amino-2-methyl-1-propanol, 10 to 20 parts of a lubricant, 10 to 20 parts of a coupling agent, 1 to 2 parts of masterbatches and 2 to 3 parts of an antioxidant. According to the high-load brush disc disclosed by the invention, the PP reworked material and the PE reworked material are utilized as basic materials, full foaming and uniform extruding are carried out on the PP reworked material and the PE reworked material, heat absorption and heat release are balanced during a foaming process, higher melt strength of polypropene is kept, bubble pores are uniform and dense, no cracking exists, the homogeneity of a brush disc product can be increased, the density and the self weight of the brush disc product are reduced, and load during a working process can be borne to a larger extent by using the brush disc product as the brush disc of the window wiper.

The invention discloses a 6-bromotryptamine derivative as well as a preparation method and application thereof. The 6-bromotryptamine derivative is characterized by being expressed by a structural formula (I) and comprising 6-bromotryptamine chloro-phenylacetic acid and 6-bromotryptamine phenylpropionic acid. The preparation method comprises the following steps: weighing chloro-phenylacetic acid or phenylpropionic aci, dissolving with dichloromethane, further adding EDC.HCl till a white muddy liquid is generated, further adding HOBt, stirring for 30 minutes at normal temperature till a white muddy phenomenon is vanished, detecting the reaction process through thin-layer chromatography, when new points occur, dropping dichloromethane in which 6-bromotryptamine is dissolved into a reaction liquid, performing stirring reaction at room temperature, leaving to stand over night, performing thin-layer chromatography detection, terminating reaction if raw material points are eliminated, boiling off a solvent so as to obtain a crude product, finally separating a trace product by using semi-preparative type liquid chromatogram, and purifying, thereby obtaining the 6-bromotryptamine derivative. The 6-bromotryptamine derivative has the advantages that AchE can be remarkably inhibited, and the 6-bromotryptamine derivative has the potential of being developed into medicines for treating the Alzheimer's disease.

Disclosed is as represented by Formula I a compound or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof of the present invention can be used as an immunosuppressant. By regulating the transport of leukocytes, and by regulating the cellular transport of lymphocytes, the lymphocytes are gathered in secondary lymphoid tissues, thus improving the integrity of blood vessels to allow for immunosuppression effect, anti-inflammatory activity, and hemostatic effect.

Provided are a phenylalanine compound having a nitrogen heterocyclic link that can substantially lower blood sugar and regulate glycolipid metabolic activity, pharmaceutically acceptable salts or stereoisomers thereof, pharmaceutical compositions having the compound, and the use of the compound in preparing medicines for diabetics and glycolipid metabolic disorders, in particular, the use thereof in preparing medicines for treating type II diabetes. The compound has a structure as presented in formula I.

The invention discloses a preparation method and electrocatalytic application of a perovskite electrode material. The method is characterized by comprising the following steps of: mixing La(NO3)3.6H2Oserving as a lanthanum source with an iron source Fe(NO3)3.9H2O, a cobalt source Co(NO3)2.6H2O or a nickel source Ni(NO3)2.6H2O, taking citric acid monohydrate as a complexing agent, and adopting a sol-gel method to obtain a perovskite electrode material, using the obtained perovskite electrode material as a cathode material for acetophenone asymmetric electrocarboxylation reaction to synthesize2-hydroxy-2-phenylpropionic acid with optical activity, and carrying out electrocarboxylation reaction under normal-pressure saturated carbon dioxide. Compared with the prior art, the electrode material is simple to prepare and low in cost, has good catalytic activity in electrocarboxylation reaction of acetophenone, is an electrocatalytic material with a good application prospect, can effectivelyutilize carbon dioxide gas with a greenhouse effect, and realizes conversion of acetophenone and effective synthesis of chiral substances.

The invention discloses a polyurethane material and polyurethane foam. The polyurethane material comprises a deodorant, wherein the deodorant comprises (1) isooctyl 3,5-di-tert-butyl-4-hydroxyphenylpropionate, (2) poly(dipropylene glycol)phenyl phosphite ester, and (3) 2-(2-hydroxy-5-methylphenyl)benzotriazole or 2-hydroxy-4-n-octyloxybenzophenone; According to the invention, by adding the composition with specific components, odor removal effect is achieved, the odor of the polyurethane material is greatly reduced, and the polyurethane material is more environmentally friendly and worthy of popularization.

The invention discloses a silane crosslinked flame-retardant semiconductive polyolefin sheathing material, a preparation method therefor and an application of the sheathing material. The sheathing material comprises a raw material A and a raw material B, wherein the raw material A comprises linear low-density polyethylene, an ethylene-vinyl acetate copolymer, an ethylene-octylene copolymer, a flame retardant, conductive carbon black, vinyl-containing silane, an initiator and a pre-crosslinking resisting agent, and the raw material B comprises linear low-density polyethylene and a hydrolyst; and the pre-crosslinking resisting agent is prepared through subjecting 2-vinyl-1H-benzimidazole and 3-phenyl-2-methyl-2-acryl propionate to copolymerization. The preparation method comprises the stepsof preparing the silane grafted raw material A, then, mixing the silane grafted raw material A with the raw material B according to a formula, carrying out extrusion molding, and then, carrying out water-cooking crosslinking, thereby preparing the sheathing material. The invention further discloses a coal-mine gas exhaust pipe containing the above-mentioned material. The sheathing material disclosed by the invention not only has good electric conductivity and flame retardancy, but also has the characteristics of excellent mechanical properties, high-temperature resistance, long service life and the like.

The invention discloses a tenofovir bisphenylpropionate phosphoramidate compound and salt thereof, and also discloses a preparation method and a pharmaceutical composition containing the tenofovir bisphenylpropionate phosphoramidate compound. Tests prove that the compound has the activity of inhibiting HBV virus replication, and has the advantages of higher activity, higher development coefficientand the like than the existing drug tenofovir disoproxil fumarate (TAF) for treating AIDS. The tests also prove that the compound also has the activity of inhibiting HIV1 virus replication, and can be used for developing medicines for treating AIDS or medicines for treating hepatitis B.

The invention relates to a synthetic method of novel chemicals, in particular to a preparation method of 2-guanidino phenylpropionic acid. The preparation method comprises the main steps: step one, stirring and mixing phenylalanine with purified water, thus forming a mixed solution; step two, regulating the PH (Potential of Hydrogen) value of the mixed solution to be 8 to 10 by using liquid caustic soda; step three, starting to dropwise add hydrogen cyanamide while rising the temperature of the mixed solution obtained in the step two to 60 to 80 DEG C; step four, starting to cool to 20 DEG C or less after keeping warm for 2 hours; step five, regulating the PH value of the mixed solution to be 6 to 8 by using hydrochloric acid; step six, centrifuging, drying and packaging. The 2-guanidino phenylpropionic acid is a new compound, a small amount of information shows that the 2-guanidino phenylpropionic acid is a derivative of aromatic amino acid needed by a human body, and the 2-guanidinophenylpropionic acid has a very important function in the fields of medicinal intermediates, food and feed. According to the preparation method disclosed by the invention, the 2-guanidino phenylpropionic acid is produced by adopting the phenylalanine, the liquid caustic soda, the hydrochloric acid and the hydrogen cyanamide as main raw materials, and the preparation method has the advantages thatthe technology is simple, the reaction is mild, the yield is high, the product purity is high, greening and environment protection are realized, and the like.

The invention relates to a new preparation method of a 3-alkenyl benzyne liquid crystal compound, comprising the following steps of: by using phenylpropionic acid as a raw material, carrying out a halogenation reaction to prepare an intermediate I-1; carrying out an esterification reaction on the intermediate I-1 and alcohol under the catalysis of acid or acyl chloride to prepare an intermediate I-2; letting the intermediate I-2 react with an ethynylation reagent under an alkaline condition and a transition metal catalyst to obtain I-3; preparing I-4 from I-3 under the reduction of hydroboron;preparing I-5 from I-4 through selective oxidation under the action of an oxidizing agent; and carrying out a wittig reaction on the I-5 to prepare the 3-alkenyl benzyne liquid crystal compound. According to the novel preparation method, generation of by-products in the synthesis process can be avoided, the synthesis efficiency is high, the product quality is high, the cost is low, the post-treatment method is simple and easy to implement, industrial mass production is facilitated, and the product completely meets the requirements for high quality of liquid crystal materials at present.