Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Phenylpropionic acid compound, preparation method therefor and medicinal use thereof

A compound, the technology of propionic acid, which is applied in the field of medicine and chemical industry, can solve the problems such as limited use

Active Publication Date: 2014-12-03
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sphingosine 1-phosphate also has cardiovascular and bronchoconstrictive effects, which limit its usefulness as a therapeutic drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phenylpropionic acid compound, preparation method therefor and medicinal use thereof
  • Phenylpropionic acid compound, preparation method therefor and medicinal use thereof
  • Phenylpropionic acid compound, preparation method therefor and medicinal use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] The preparation of embodiment 1:4-benzyloxybenzonitrile

[0149] According to the method of reaction scheme 1, the final product was obtained after infrared drying, and the yield was 98.4%.

[0150] 1 H-NMR (400MHz, DMSO-d6) δ (ppm): .7.78 (d, J=6.8, 2H), 7.31-7.48 (m, 5H), 7.19 (d, J=8.8, 2H), 5.21 (S , 2H), ESI-MS (M+H ＋ ), 232.2.

Embodiment 2

[0151] Embodiment 2: the preparation of 4-benzyloxy thiobenzamide

[0152] According to the method of reaction scheme 1, the product was obtained after drying with a yield of 95.6%.

[0153] 1 H-NMR (400MHz, DMSO-d6) δ (ppm): 9.64, (s, 1H), 9.32, (s, 1H), 7.94 (d, J=8.8, 2H), 7.31—7.47 (brs, 5H) , 7.17 (d, J=9.2, 2H), 5.18 (S, 1H).

Embodiment 3

[0154] Embodiment 3: Preparation of 2-(4-benzyloxyphenyl)-4-thiazolic acid ethyl ester

[0155] According to the method in Reaction Scheme 1, the intermediate 2-(4-benzyloxyphenyl)-4-thiazole acid ethyl ester was obtained with a yield of 77.3%.

[0156] 1H-NMR (400MHz, DMSO-d6) δ (ppm): 8.50 (s, 1H), 7.93 (d, J = 8.8, 2H), 7.31—7.47 (brs, 5H), 7.17 (d, J = 8.8, 2H), 5.20 (S, 1H), 4.33 (q, J=6.8, 2H), 1.33 (t, J=7.2, 3H).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Densityaaaaaaaaaa
Login to View More

Abstract

Disclosed is as represented by Formula I a compound or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof of the present invention can be used as an immunosuppressant. By regulating the transport of leukocytes, and by regulating the cellular transport of lymphocytes, the lymphocytes are gathered in secondary lymphoid tissues, thus improving the integrity of blood vessels to allow for immunosuppression effect, anti-inflammatory activity, and hemostatic effect.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to phenylpropionic acid compounds or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them, their preparation methods, and their medical applications. These compounds are SlP 1 / EDG1 receptor agonist, by regulating leukocyte transport, regulating lymphocyte cell transport, making lymphocytes gather in secondary lymphoid tissue, improving the integrity of blood vessels and exerting immunosuppressive effect, anti-inflammatory activity and hemostatic effect. Background technique [0002] Immunosuppressive and anti-inflammatory drugs have been shown to be useful in many autoimmune and chronic inflammatory diseases (including systemic lupus erythematosus, chronic rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, biliary cirrhosis, grapevine Meningitis, multiple sclerosis, and other diseases such as Crohn's disease, ulcerative ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D277/56C07D277/42C07D277/30A61K31/426A61P37/02A61P37/06A61P29/00A61P9/10A61P31/04A61P31/12
CPCC07D277/56C07D277/30C07D277/42A61P9/10A61P29/00A61P31/04A61P31/12A61P37/02A61P37/06
Inventor 李松钟武林忠宝王晓奎刘洪英谢云德赵国明郑志兵肖军海李行舟
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com