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Application of short-chain fatty acid in prevention or/and treatment of liver injury

A short-chain fatty acid and liver injury technology, applied in the field of medicine, can solve the problems of unclear effector molecules, high requirements for storage conditions, and cumbersome extraction methods, and achieve the effects of low cost, significant prevention and treatment effect, and reduced lymphocyte infiltration

Inactive Publication Date: 2021-07-30
SHANDONG SHANWEI IMMUNOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction methods of the above components are cumbersome, the cost is high, and the components are complex, the effect molecules are not clear, and the storage conditions are high.

Method used

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  • Application of short-chain fatty acid in prevention or/and treatment of liver injury
  • Application of short-chain fatty acid in prevention or/and treatment of liver injury
  • Application of short-chain fatty acid in prevention or/and treatment of liver injury

Examples

Experimental program
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Effect test

Embodiment 1

[0040] 1. Determination of the effect of propionic acid or butyric acid on the survival rate of hepatocytes exposed to alcohol

[0041] It should be noted that in the present invention, the experimental cells are human hepatoma cells HepG2, and the medium used for cell culture is Hyclone containing 10% fetal bovine serum and 1% double antibody (penicillin 100U / mL, streptomycin 100 μg / mL). High glucose DMEM medium.

[0042] The specific measurement method is as follows:

[0043] After the recovery of HepG2 cells, after passage once, the cells in the logarithmic growth phase were collected and inoculated in a 96-well plate at a concentration of 5,000 cells per well, and placed at 37°C, 5% CO 2 Incubate overnight in the incubator. In the experiment, a blank group, a negative control group and an administration group were set up, with 5 duplicate wells in each group, the original medium was sucked and discarded, the blank control group was replaced with fresh serum-free DMEM, an...

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Abstract

The invention discloses application of short-chain fatty acid in prevention or / and treatment of liver injury. The short-chain fatty acid is a product of intestinal flora glycolysis dietary fibers, belongs to an endogenous substance, is small in toxic and side effects, simple in structure, easy to metabolize, convenient to obtain and low in price, and can inhibit liver fatty degeneration and liver inflammation, improve liver functions and prevent or / and treat liver injury.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of short-chain fatty acids in preventing or / and treating liver damage. Background technique [0002] Liver injury is a common clinical disease, mainly divided into open liver injury, pathological liver injury, closed liver injury and chemical liver injury. With the development of society, the incidence of chemical liver injury is increasing, among which alcoholic liver injury caused by long-term or heavy drinking is particularly high, and has become one of the common diseases that seriously endanger human health, mainly including alcoholic fatty liver, Alcoholic hepatitis and cirrhosis. In our country, the incidence of alcoholic liver injury and its related mortality are increasing year by year, so it is very important to find effective methods to prevent and treat alcoholic liver injury. At present, the pathogenesis of alcoholic liver injury is rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61P1/16
CPCA61K31/19A61P1/16A61K2300/00
Inventor 徐琦穆岩王泉博查尔斯·雷伊·麦凯
Owner SHANDONG SHANWEI IMMUNOTECH CO LTD
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