Application of itaconic acid in preparation of medicine for treating or relieving allergic airway inflammation diseases

A technology of airway inflammation and itaconic acid, applied in the direction of allergic diseases, drug combinations, respiratory diseases, etc., to achieve significant effects and broaden the effect of drug types
CN113209067APending Publication Date: 2021-08-06THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
Publication Date
2021-08-06

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Abstract

The invention belongs to the field of airway inflammation medicine application, and relates to application of itaconic acid in preparation of a medicine for treating or relieving allergic airway inflammation diseases. In the application, itaconic acid inhibits lung tissue inflammatory cell infiltration, mucus secretion, Th2 cytokine generation, NLRP3 inflammasome activation and oxidative stress injury in a targeted mode for treating or relieving allergic airway inflammation. According to the application, the immune metabolite itaconic acid is introduced into the treatment of the allergic airway inflammation disease for the first time, a new method for treating or relieving the allergic airway inflammation is found, and a new target and a brand new idea are provided for preparing the medicine for treating the allergic airway inflammation disease. The itaconic acid is an endogenous immune metabolite and has the characteristics of high safety and low toxicity, and the application of the itaconic acid to the development process of drugs related to the allergic airway inflammation diseases broadens the types of drugs for treating the allergic airway inflammation diseases such as asthma, allergic bronchitis and allergic rhinitis.
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Description

technical field

[0001] The invention relates to the medical application field of airway inflammation, and relates to a new application of a substance, in particular to an application of itaconic acid in the preparation of a medicine for treating or alleviating allergic airway inflammation. Background technique

[0002] Itaconic acid is an important chemical raw material, also known as methylene succinic acid, methylene succinic acid, formosuccinic acid, etc. Itaconic acid and toluidine undergo a series of reaction processes to produce 4-[1-methylbenzene-2-pyrrolidone-4-yl]-methoxybenzoic acid, which is esterified with coenzyme A in the body , has a strong inhibitory effect on cholesterol synthase and fatty acid synthase. Thereby inhibiting the synthesis of fatty acids and cholesterol in the human body, it is a new drug for preventing and treating various diseases such as arteriosclerosis, diabetes and obesity.

[0003] During in vivo metabolism, the immune metabolite Itaco...

Claims

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