Drug solubilizing system and application thereof in pesticide preparation

A technology for pesticide preparations and medicines, which is applied to a medicine solubilization system and its application field in pesticide preparations, can solve the problems of unstable dispersed aqueous solution and insoluble medicines in water, etc.

Active Publication Date: 2021-08-24
ZHEJIANG UNIV OF TECH +1
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a drug solubilization system and its application in pesticide preparations to solve the problems of insoluble drugs in water and instability of dispersed aqueous solutions in view of the shortcomings of the above-mentioned solid dispersions.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug solubilizing system and application thereof in pesticide preparation
  • Drug solubilizing system and application thereof in pesticide preparation
  • Drug solubilizing system and application thereof in pesticide preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Select the poloxamer high molecular polymer, and stir the poloxamer and hydroxymethylated rosin in an oil bath at 80°C for 1.5 hours by hot-melt method to obtain a uniform and stable hot-melt product, and then add pyrimidine Strobestrobin and Kungfu-thrin, continue magnetic stirring for 30 minutes to obtain a homogeneous system, cool to obtain a drug-loaded solid dispersion. The experimental components are shown in Table 1.

[0016] Table 1

[0017]

Embodiment 2

[0019] Select PEG 6000 high molecular polymer, and PEG 6000 and hydroxymethylated rosin were stirred magnetically for 1.5 hours in an oil bath at 80°C by hot-melt method to obtain a uniform and stable hot-melt product, and then added azoxystrobin, kung fu Pyrethrin, continue magnetic stirring for 30 minutes to obtain a homogeneous system, cool to obtain a drug-loaded solid dispersion, the experimental components are shown in Table 2.

[0020] Table 2

[0021]

[0022] Put 1 g of the obtained solid dispersion into a beaker, add 250 ml of hard water, and stir on a 100 r / min magnetic stirrer at 25° C. Record the complete disintegration time of the drug solid in the beaker. Dilute the above-mentioned completely disintegrated drug solution by 100 times, take the supernatant after standing still, inject the sample through a 0.45 μm microporous membrane, measure the peak area by HPLC, and calculate the dissolved amount of the drug in water according to the standard curve.

Embodiment 3

[0024] Select PVP K30 high molecular polymer, dissolve PVP K30 and hydroxymethylated rosin with methanol through solvent evaporation method, then add azoxystrobin and kaufthrin, stir magnetically for 30 minutes, and obtain a homogeneous system after the solvent is evaporated, cool, The drug-loaded solid dispersion was obtained, and the experimental components are shown in Table 3.

[0025] table 3

[0026]

[0027] Put 1 g of the obtained solid dispersion into a beaker, add 250 ml of hard water, and stir on a 100 r / min magnetic stirrer at 25° C. Record the complete disintegration time of the drug solid in the beaker. Dilute the above-mentioned completely disintegrated drug solution by 100 times, take the supernatant after standing still, inject the sample through a 0.45 μm microporous membrane, measure the peak area by HPLC, and calculate the dissolved amount of the drug in water according to the standard curve.

[0028] The results obtained for the above examples are sho...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a drug solubilizing system and application thereof in pesticide preparation, the drug solubilizing system is formed by compounding hydroxymethylated rosin and poloxamer, and the mass ratio of the hydroxymethylated rosin to the poloxamer is 1: (1-6). The pesticide is an indissolvable drug, the indissolvable drug and the drug solubilizing system are compounded to form a pesticide preparation, and the mass ratio of the indissolvable drug in the pesticide preparation is 10-50%. According to the invention, hydroxymethylated rosin and poloxamer are compounded to form the solubilizing system for solubilizing insoluble drugs. Poloxamer converts an insoluble drug crystal into a non-crystal, distribution of the insoluble drug in water is greatly stabilized by amphipathicity of hydroxymethylated rosin acid, and hydroxymethylated rosin and poloxamer are combined through hydrogen bonds to form a stable system so that the stability of the pharmaceutical preparation is further improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and more specifically relates to a drug solubilizing system and its application in pesticide preparations. Background technique [0002] Pharmaceutical preparations are an important part of drug entry into the market. Whether it is human medicine or animal medicine, the same processing of pharmaceutical dosage forms for agricultural use is also particularly important. Raw materials need to be prepared into specific dosage forms through some processes before they can enter the market and be used. The traditional pesticide formulations mainly include water formulations, water dispersible granules, wettable powders, and emulsifiable concentrates. Traditional formulations of pesticides have many defects, such as the waste of a large amount of drugs and the potential harm to the environment. Gradually, many environmentally friendly pesticide formulations such as aqueous emulsions, microemul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N25/14A01N43/54A01N53/08A01P7/04
CPCA01N43/54A01N53/00A01N25/10A01N25/14Y02A50/30
Inventor 翟晚娜蒋园佳付媛丽王纯洁金志敏龚国华
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap