Frequency shift super-resolution optical chip for solving illumination light dispersion problem in imaging process
An optical chip and super-resolution technology, applied in the field of frequency-shifting super-resolution optical chips, can solve problems such as illumination light dispersion, achieve the effects of expanding the range of light sources, facilitating promotion and mass production, and reducing production and use costs
Active Publication Date: 2021-08-24
ZHEJIANG UNIV
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Problems solved by technology
The present invention can effectively solve the illumination light dispersion problem existing in the on-chip frequency-shifting super-resolution imaging process
Method used
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[0075] Such as figure 1 The shown frequency-shifting super-resolution microchip, taking a rectangular waveguide as an example, includes the following parts: an Al2O3 substrate 101 as a functional layer, an Al2O3 substrate 102 as an imaging layer, a grating Pm' for eliminating dispersion, and a shifting Frequency diffraction grating Pm, etc.
[0076] Such as figure 2 The structure of the imaging system shown includes the following parts: a polychromatic light source array 201 as an illumination source, a sample stage 202, a frequency-shifting super-resolution microchip 203, a microscopic objective lens 204, a lens for super-resolution image collection, and a color camera etc., and the image reconstruction unit 207.
[0077] The sample stage 202 can fine-tune the distance between the lens and the frequency-shifting super-resolution microchip and the distance between the lens and the color camera through the fine-tuning knob.
[0078] The grating Pm’ used to eliminate dispers...
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Abstract
The invention discloses a frequency shift super-resolution optical chip for solving the problem of illumination light dispersion in the imaging process, the optical chip is composed of two substrates made of the same material, one substrate is a functional layer, the other substrate is an imaging layer, the two substrates are parallel, and m circles of paired gratings are respectively engraved on the upper surface and the lower surface of the functional layer. Light with different wavelengths is incident at the same angle, and finally converges into a beam of composite light after passing through the double-grating structure, so that the convergence effect of the grating on the light is realized, and the effect of eliminating dispersion of the previous grating is achieved. The problem of illumination light dispersion of the frequency-shift optical super-resolution microscopic chip is solved by utilizing the de-dispersion characteristic of the double gratings, the illumination dispersion caused by the wide spectrum of complex-color illumination light is reduced, the resolution of an imaging system is effectively improved, the obstacle that the chip uses a complex-color light source is solved, and the method is of great significance to diversification of illumination light of the frequency-shift super-resolution microscopic chip and cost reduction.
Description
technical field [0001] The invention relates to the field of frequency-shifting super-resolution optical chips, in particular to a frequency-shifting super-resolution optical chip for solving the dispersion problem of illumination light in the imaging process. Background technique [0002] The life activities of organisms are all completed by cells, and the specific conditions of life activities of living bodies can be learned through the study of cells. However, biological microscopes are limited by the Abbe diffraction limit, and their resolution often cannot meet the requirements for clearly seeing cell activities. In order to study various life activities of cells, it is necessary to use a microscope with higher resolution, so super-resolution technology is required. Classical super-resolution microscopy methods such as SIM and PSIM require complex optical paths and heavy equipment to realize. Optical super-resolution microchips can simplify complex structures and integ...
Claims
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IPC IPC(8): G01N21/84G01N21/01G02B5/18
CPCG01N21/84G01N21/01G02B5/1823G02B5/1809G02B5/1842
Inventor 杨青李雪驰罗贤勇汤明炜
Owner ZHEJIANG UNIV