Compound cordycepin agent as well as preparation method and application thereof in preparation of products against small cell lung cancer

A compound cordycepin and cordycepin technology, which can be used in applications, functions of food ingredients, and medical preparations containing active ingredients, etc., can solve problems such as upper abdominal pain, and achieve the goal of curbing hyperplasia, reducing side effects, and enhancing drug efficacy Effect

Inactive Publication Date: 2021-09-03
南京生命原健康科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it also has some side effects at the same time, such as mild poisoning, or only itching of the oral mucosa and throat, which can be completely relieved through its own metabolism after several hours, and those with severe poisoning may have upper abdominal pain, nausea, vomiting, Diarrhea and other symptoms

Method used

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  • Compound cordycepin agent as well as preparation method and application thereof in preparation of products against small cell lung cancer
  • Compound cordycepin agent as well as preparation method and application thereof in preparation of products against small cell lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) Preparation of compound cordycepin preparation

[0070] According to the mass of cordycepin, yew extract and solanum nigrum extract, each composition was weighed as 50 mg: 900 mg: 50 mg, mixed and dissolved in 1 L of physiological saline water.

[0071] (2) Four groups of mice were set up for gavage experiment. There were 5 male and female mice in each group. High-dose group, middle-dose group, low-dose group and blank control group were used respectively. The dosage for the mice in the high-dose group was 80 mg / kg, the dosage for the mice in the middle-dose group was 50 mg / kg, and the dosage for the mice in the low-dose group was 20 mg / kg. The blank control group was an equal volume of normal saline. 2 times a day. Lasts 22 days. The detection method refers to the above method.

[0072] The experimental results are shown in Table 1-Table 3:

[0073] Table 1

[0074] Group Weight loss rate (%) stool hardness blood in stool / occult blood hair...

Embodiment 2

[0080] (1) Preparation of compound cordycepin preparation

[0081] According to the mass of cordycepin, yew extract, and nightshade extract, each composition was weighed as 900 mg: 50 mg: 50 mg, mixed and dissolved in 1 L of physiological saline water.

[0082] (2) Four groups of mice were set up for gavage experiment. There were 5 male and female mice in each group. High-dose group, middle-dose group, low-dose group and blank control group were used respectively. The dosage for the mice in the high-dose group was 80 mg / kg, the dosage for the mice in the middle-dose group was 50 mg / kg, and the dosage for the mice in the low-dose group was 20 mg / kg. The blank control group was an equal volume of normal saline. 2 times a day. Lasts 22 days. The detection method refers to the above method.

[0083] The experimental results are shown in Table 4-Table 6:

[0084] Table 4

[0085] Group Weight loss rate (%) stool hardness blood in stool / occult blood hair re...

Embodiment 3

[0091] (1) Preparation of compound cordycepin preparation

[0092] According to the mass of cordycepin: yew extract: solanum nigrum extract: 50 mg: 50 mg: 900 mg, each composition was weighed, mixed and dissolved in 1 L of physiological saline water.

[0093] (2) Four groups of mice were set up for gavage experiment. There were 5 male and female mice in each group. High-dose group, middle-dose group, low-dose group and blank control group were used respectively. The dosage for the mice in the high-dose group was 80 mg / kg, the dosage for the mice in the middle-dose group was 50 mg / kg, and the dosage for the mice in the low-dose group was 20 mg / kg. The blank control group was an equal volume of normal saline. 2 times a day. Lasts 22 days. The detection method refers to the above method.

[0094] The experimental results are shown in Table 7-Table 9:

[0095] Table 7

[0096] Group Weight loss rate (%) stool hardness blood in stool / occult blood hair remo...

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Abstract

The invention discloses a compound cordycepin agent as well as a preparation method and an application thereof in preparation of products against small cell lung cancer. The compound cordycepin agent comprises the following components in parts by weight: 20-500 parts of cordycepin, 5-100 parts of black nightshade herb extract and 1-20 parts of taxus chinensis extract. The compound cordycepin agent provided by the invention not only can enhance therapeutic efficacy on small cell lung cancer, but also can reduce the side effects.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a compound cordycepin preparation, a preparation method thereof and an application in preparation of anti-small cell lung cancer products. Background technique [0002] Small cell lung cancer accounts for about 15%-20% of bronchial lung cancers. When small cell lung cancer is diagnosed, about 30% of the patients are in the limited stage, and the rest are in the extensive stage (when the tumor spreads beyond the supraclavicular area, it is extensive). Expect). Compared with other types of lung cancer, small cell lung cancer has better efficacy of chemotherapy and radiotherapy. But because the tumor is likely to have spread widely by the time SCLC is diagnosed, SCLC is often difficult to treat. [0003] Cordycepin, also known as cordycepin, cordycepin, and cordycepin, also known as 3′-deoxyadenosine, is the first nucleoside antibiotic isolated from fungi. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P11/00A61P35/00A23L33/105A61K36/068A61K36/13A61K31/7076
CPCA61K36/068A61K36/81A61K36/13A61K31/7076A61P11/00A61P35/00A23L33/105A23V2002/00A61K2300/00A23V2200/314A23V2200/308Y02A50/30
Inventor 应汉杰唐成伦陈勇温庆仕刘庆国赵南
Owner 南京生命原健康科技有限公司
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