Wound exudate responsive controlled released hydrogen sulfide probe and preparation method and application thereof
A technology of exudate and hydrogen sulfide, applied in the field of medical materials, can solve problems such as toxic by-products, achieve rapid and efficient release, good repair effect, fast and efficient real-time self-monitoring effect
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[0048] Preparation of Precursor Compound III-2:
[0049] 5-(4-(Diphenylamine)phenyl)thiophene-2-carbaldehyde (354 mg, 1.0 mmol), 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene Methyl)malononitrile (301mg, 1.5mmol) was placed in a mixed solvent of ethanol / tetrahydrofuran (6:4 by volume), and stirred under reflux for 5h under a nitrogen atmosphere. After the reaction was completed, purification was carried out by silica gel column chromatography to obtain III-2 with a yield of ~59%. 1 H NMR (CDCl 3 , 400MHz): δ7.81(d, J=16.0Hz, 1H), 8.20(dt, J 1 =8.8Hz,J 2 = 4.4Hz,J 3 =2.4Hz, 2H), 7.44(d, J=4.4Hz, 1H), 7.34(d, J=1.6Hz, 1H), 7.33-7.28(m, 4H), 7.19-7.09(m, 6H), 7.06 (d, J=8.8Hz, 2H), 6.62(d, J=15.6Hz, 1H), 1.76(s, 6H); 13 C NMR (CDCl 3 ,101MHz):δ175.65,173.06,153.94,149.56,146.67,139.61,137.89,137.47,129.57,127.19,125.48,124.26,124.06,121.89,112.08,112.00,111.30,110.87,104.97,97.05,96.71,77.33, 77.22, 77.01, 76.69, 29.70, 26.54. ESI-HRMS: m / z [M+H + ] Theory C 34 h 25 N ...
Embodiment 1
[0052] Preparation of probe I-2:
[0053] Weigh 10mg of precursor compound III-2, dissolve it with DMSO and configure it into a 10.5mmol / L solution; weigh 5mgNa 2 S, dissolved in ultrapure water and made into a 100mmol / L solution; take 950μL of the 10.5mmol / L solution of III-2, add 50μL Na 2 100mmol / L solution of S and mix well to obtain probe I-2.
[0054] The structure of I-2 is:
[0055]
Embodiment 2
[0057] Preparation of probe II-2:
[0058] Weigh 10mg of precursor compound III-2, dissolve it in DMSO and make it into a 10.5mmol / L solution; weigh 5mg of NaHS, dissolve it in ultrapure water and make it into a 200mmol / L solution; take III-2’s 10.5mmol / L Solution 950μL, add 50μL NaHS 200mmol / L solution and mix well to obtain probe II-2.
[0059] The structure of II-2 is:
[0060]
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