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Preparation method and application of novel ionic liquid functionalized injectable conductive hydrogel

A technology of conductive hydrogel and ionic liquid, which is applied in application, electrotherapy, liquid delivery, etc., can solve the problems of unfavorable human body and inability to cover the wound area, and achieve the effect of short gelation time, excellent antibacterial performance and stable structure

Active Publication Date: 2021-10-01
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
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Problems solved by technology

However, current electrode-based ES strategies suffer from some limitations, for example, the applied ES cannot cover the entire wound area, and high-parameter ES applied on large wounds is also unfavorable to the human body (Y.Lu, Y.Wang, J. Zhang, X. Hu, Z. Yang, Y. Guo, Y. Wang, Acta Biomaterialia, 2019, 89: 217-226)

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  • Preparation method and application of novel ionic liquid functionalized injectable conductive hydrogel
  • Preparation method and application of novel ionic liquid functionalized injectable conductive hydrogel
  • Preparation method and application of novel ionic liquid functionalized injectable conductive hydrogel

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Embodiment 1

[0064] Embodiment 1 A preparation method of a novel ionic liquid functionalized injectable conductive hydrogel, comprising the following steps:

[0065] (1) PolyPBAimBF 4 Preparation of ionic liquids;

[0066] (a) PBAimBF 4 Preparation of ionic liquid:

[0067] Dissolve 1-(3-aminopropyl)imidazole (7mmol, 0.876g) in acetonitrile, add 0.216gNaH at 0°C, and transfer it to an oil bath after reacting for 3h. After the temperature rises to 80°C, 1,2-Dibromoethylene (3mmol, 0.558g) was added dropwise, under the protection of N2, the reaction was stirred by magnetic force for 24h. After the solvent was removed by rotary evaporation, the product was dissolved in a small amount of methanol and washed three times with anhydrous ether. Subsequently, the product was added to a saturated aqueous solution of sodium tetrafluoroborate, and stirred at room temperature for 2 h. After the reaction stopped, dichloromethane extracted several times, and dilute AgNo 3 Solution confirmed Br - an...

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Abstract

The invention belongs to the technical field of biomedical material preparation, and particularly relates to a preparation method and application of novel ionic liquid functionalized injectable conductive hydrogel. Through preparing bis-aminoimidazole tetrafluoroborate ionic liquid containing positive charge active groups, namely 1, 1'-(ethyl-1, 2-)-bis-(3-(3-aminopropyl))-1H imidazole tetrafluoroborate ionic liquid, after polymerizing, aldehyde group functionalized hyaluronic acid is then mixed in a mass ratio of 3: (1-4), and through a Schiff base reaction , a novel injectable conductive hydrogel PIL-OHA is obtained. The hydrogel PIL-OHA prepared by the invention has excellent antibacterial property and mechanical property, and can remarkably promote skin wound healing of diabetic model mice when coupled with external alternating current stimulation.

Description

[technical field] [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a preparation method and application of a novel ionic liquid functionalized injectable conductive hydrogel. [Background technique] [0002] More than 6.5 million people worldwide suffer from diabetic wounds, with an annual healthcare cost of over US$25 billion (Y.Lu, Y.Wang, J.Zhang, X.Hu, Z.Yang, Y.Guo, Y.Wang, ActaBiomaterial, 2019 , 89: 217-226). The current treatment methods for diabetic wounds include hyperbaric oxygen therapy, negative pressure wound therapy, growth factors and the application of skin substitutes, but these strategies are costly, take a long time, and cannot achieve satisfactory therapeutic results. Therefore, the accelerated and thorough treatment of chronic wounds Treatment is facing great challenges (Q. Bai, K. Han, K. Dong, C. Zheng, Y. Zhang, Q. Long, T. Lu, International Journal of Nanomedicine, 2020, 15: 971...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K50/00A61K9/06A61K31/728A61K31/787A61P17/02A61P31/04A61L24/08A61L24/06A61L24/00C08J3/075C08B37/08
CPCA61K9/0009A61K9/06A61K31/728A61K31/787A61P17/02A61P31/04A61P7/04A61L24/08A61L24/06A61L24/0015A61L24/0031A61L24/001C08J3/075C08B37/0072A61L2400/06A61L2400/04A61L2300/232A61L2300/216A61L2300/404A61L2300/418C08J2305/08C08L5/08A61K2300/00
Inventor 李春涯刘盼王炎英何梦
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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