Veterinary altrenogest composition, veterinary altrenogest soft capsule as well as preparation method thereof and applications of veterinary altrenogest composition or veterinary altrenogest soft capsule

A technology of allyrogestin and soft capsule, which is applied in the directions of capsule delivery, drug combination, medical preparations of inactive ingredients, etc., can solve the problems of inaccurate dosage, influence on content, inconvenience, etc

Pending Publication Date: 2021-10-08
吉林吉力生物技术研究有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the dosage form of allylgestrol on the market is an oral solution, which is inaccurate in dosage, inconvenient for storage and transportation, needs utensils or sprayed on food, and is extre

Method used

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  • Veterinary altrenogest composition, veterinary altrenogest soft capsule as well as preparation method thereof and applications of veterinary altrenogest composition or veterinary altrenogest soft capsule
  • Veterinary altrenogest composition, veterinary altrenogest soft capsule as well as preparation method thereof and applications of veterinary altrenogest composition or veterinary altrenogest soft capsule
  • Veterinary altrenogest composition, veterinary altrenogest soft capsule as well as preparation method thereof and applications of veterinary altrenogest composition or veterinary altrenogest soft capsule

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[0039] The present invention also provides a preparation method of the above-mentioned allylgestin soft capsule for animals, comprising the following steps:

[0040] Mix the vitamin E and part of the vegetable oil, heat to 55-65° C., mix the allylgestrin and the remaining vegetable oil after cooling to obtain a soft capsule filling liquid; the weight ratio of the part of the vegetable oil to the remaining vegetable oil is 3: 2;

[0041] Mix the gelatin, plasticizer, opacifier, flavoring agent and water, heat up to 75°C, vacuumize, filter through a 100-mesh screen, keep warm at 55-65°C, and obtain the shell material of the soft capsule;

[0042] The filling liquid of the soft capsule is mixed with the shell material of the soft capsule, and pelletized to obtain the allylregestin soft capsule for animals.

[0043] In the present invention, the vitamin E is mixed with part of the vegetable oil, heated to 55-65° C., and after cooling, the allylgestrin and the remaining vegetable ...

Example Embodiment

[0049] Example 1

[0050] A composition of allylrenogest for veterinary use is composed of the following components: 0.5g of allylregestin, 6g of vitamin E and 86g of refined soybean oil.

Example Embodiment

[0051] Example 2

[0052] A composition of allylrenogest for animals is composed of the following components: 5g of allylregestin, 2g of vitamin E and 85g of refined peanut oil.

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Abstract

The invention belongs to the technical field of veterinary drug preparation, and particularly relates to a veterinary altrenogest composition, a veterinary altrenogest soft capsule as well as a preparation method thereof and applications of the veterinary altrenogest composition or the veterinary altrenogest soft capsule. The veterinary altrenogest composition includes, in parts by weight, 0.5-5 parts of altrenogest, 1-6 parts of vitamin E and 80-95 parts of vegetable oil. By compounding the proper altrenogest, the vitamin E and the vegetable oil, female hormone concentration of female livestock is increased, fertility is improved, abortion is prevented, the vitamin E and the main drug altrenogest have a synergistic effect, the utilization rate of the drug can reach the maximum, and the vitamin E can make the stability of the preparation better. The oxidation influence caused by long-term storage is avoided.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary medicines, and in particular relates to a composition of veterinary allylprogesterone, a veterinary use of allylrenogest soft capsule and a preparation method and application thereof. Background technique [0002] Allylgestrol is an orally active progestin that inhibits gonadotropin release in a mode of action similar to that of natural progesterone. Allylregestin is insoluble in water but soluble in organic solvents. It is chemically very unstable and sensitive to oxygen. [0003] At present, the dosage form of allylgestrol on the market is an oral solution, which is inaccurate in dosage, inconvenient for storage and transportation, requires utensils or sprayed on food, and is extremely inconvenient to use, and the stability of oral solutions is generally poor. , Long-term storage is easy to oxidize and affect the content, which in turn affects the bioavailability and curative ...

Claims

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Application Information

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IPC IPC(8): A61K31/567A61K31/355A61K47/44A61K47/22A61K9/48A61P15/06A61P15/08
CPCA61K31/567A61K31/355A61K47/44A61K47/22A61K9/4858A61P15/06A61P15/08A61K2300/00
Inventor 张国军岑岳明陈博王兆哲齐宇蒋依倩
Owner 吉林吉力生物技术研究有限公司
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