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Chitosan hydrogel, preparation method and application of chitosan hydrogel in gastric filling agent

A technology of chitosan and chitosan, which is applied in the field of medical assistance, can solve the problems of increasing the production cost of gastric fillers, complex synthesis or modification procedures, and the absence of gastric fillers, so as to improve the effect of weight loss, simple preparation process, low cost effect

Inactive Publication Date: 2021-10-22
吴良平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It must be a long-term process to assist weight loss by taking gastric fillers. However, the current gastric fillers themselves do not have the physiological function of directly regulating the user's weight, and the weight loss effect is limited; meanwhile, the gastric filler hydrogel needs to be more complicated. The modification process, in addition to the additional risk of residual monomers or additives in the reaction process, also increases the production cost of gastric fillers, which leads to the fact that gastric fillers do not occupy a competitive advantage in the increasingly abundant weight loss treatment pathways

Method used

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  • Chitosan hydrogel, preparation method and application of chitosan hydrogel in gastric filling agent
  • Chitosan hydrogel, preparation method and application of chitosan hydrogel in gastric filling agent
  • Chitosan hydrogel, preparation method and application of chitosan hydrogel in gastric filling agent

Examples

Experimental program
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Effect test

Embodiment 1-4

[0038] A chitosan hydrogel gastric filling agent adopts the following preparation method:

[0039] S1, weigh chitosan in proportion, and be dissolved in the acetic acid solution that massfraction is shown in table 1, make the chitosan massfraction that chitosan massfraction is shown in table 1 for subsequent use;

[0040] Wherein, the molecular weight of chitosan is as shown in table 1, and the degree of hexanoylation is as shown in table 1;

[0041] S2. Weigh the polyanionic natural polysaccharide in proportion and dissolve it in water to prepare a polyanionic natural polysaccharide solution whose mass fraction is shown in Table 1 for subsequent use;

[0042] Wherein, the selected polyanionic natural polysaccharide and pure water are made into an aqueous solution with a mass fraction of 2%, and the viscosity of the aqueous solution detected at 25° C. is as shown in Table 1;

[0043] S3, in the polyanionic natural polysaccharide solution, add silicone oil above food grade, th...

Embodiment 5

[0051] A chitosan hydrogel gastric filling agent differs from Example 4 in that the mass ratio of chitosan and polyanionic natural polysaccharide is 10:0.05.

Embodiment 6

[0053] A chitosan hydrogel gastric filling agent differs from Example 4 in that the mass ratio of chitosan and polyanionic natural polysaccharide is 10:1.

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Abstract

The invention discloses chitosan hydrogel as well as a preparation method and an application of the chitosan hydrogel in gastric filling agents, and relates to the field of medical assistance. The chitosan hydrogel comprises chitosan and polyanionic natural polysaccharide. The preparation method comprises the following steps: dissolving the chitosan in a solvent A to prepare a chitosan acetic acid solution; dissolving polyanionic natural polysaccharide in a solvent B to prepare a polyanionic natural polysaccharide solution; adding silicone oil into a polyanionic natural polysaccharide solution, stirring, adding a chitosan acetic acid solution to form a solution with gel microspheres, stirring, and adjusting the pH value; seperating the gel microspheres from the solution in a centrifugal mode, rinsing the gel microspheres with pure water, obtaining the chitosan hydrogel after drying, and applying the chitosan hydrogel to the gastric filling agent. The chitosan hydrogel serving as the gastric filling agent has the high swelling ratio and the high pH sensitivity, meanwhile, the body weight can be actively adjusted, the preparation steps are simple, the cost is low, and the components are safe.

Description

technical field [0001] The invention relates to the field of medical assistance, in particular to a chitosan hydrogel, a preparation method and its application in gastric fillers. Background technique [0002] Over the past few decades, obesity and excessive weight gain have become a global epidemic. Exercise weight loss combined with diet control is recognized as the safest and most effective way to lose weight. The key is exercise, but it must also be combined with scientific diet control. While paying attention to controlling calorie intake, it must ensure that the normal nutritional needs of the human body are met. [0003] The essence of diet control is to fight against people's instinctive hunger. Ordinary people often lack the willpower to persist for a long time. For this reason, additional auxiliary means are needed to artificially provide a sense of satiety to reduce the difficulty of diet control. Hydrogel is a three-dimensional network polymer with strong hydrop...

Claims

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Application Information

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IPC IPC(8): A23L33/125A23L29/30
CPCA23L33/125A23L29/30A23V2002/00A23V2200/332A23V2250/022A23V2250/511
Inventor 吴良平戴晓江黄红艳
Owner 吴良平
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