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Nano drug delivery system as well as preparation method and application thereof

A drug delivery system and nano technology, applied in the field of nano drug delivery system and its preparation, can solve the problems of large side effects, poor treatment effect, cardiotoxicity, etc., and achieve the effects of reducing side effects, good application prospects, and uniform particle size.

Pending Publication Date: 2021-10-22
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the present invention proposes a nanometer drug delivery system, which can effectively solve the problems of existing drugs for treating tumors, which have large side effects, poor therapeutic effect, and are prone to cardiotoxicity.

Method used

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  • Nano drug delivery system as well as preparation method and application thereof
  • Nano drug delivery system as well as preparation method and application thereof
  • Nano drug delivery system as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The construction of embodiment 1 nano drug delivery system

[0053] In this embodiment, a nano drug delivery system is constructed, and the specific process is as follows:

[0054] 1. Synthesis of mesoporous Prussian blue nanoparticles (MPB NPs)

[0055] Weigh 3.0g PVP and dissolve in 40mL 0.01M HCl solution, then add 132mg K 3 [Fe(CN) 6 ] After stirring for 30min, it was transferred to a polytetrafluoroethylene reactor and placed in an oven at 80°C for 24h. Then take it out to room temperature (25°C) to cool, and centrifuge at 12000rpm for 30min to collect the blue precipitate; then wash with ethanol and water three times to remove unreacted raw materials, and centrifuge to obtain MPB NPs.

[0056] 2. Synthesis of EGCG-Fe NPs

[0057] Weigh 1.0g PVP and dissolve it in 10mL pure water, then add 0.2mL FeCl 3 solution (100 mg / mL); after stirring for 1 h, 1 mL of EGCG solution (3.36 mg / mL) was added dropwise to the above mixture and stirred for 12 h. After the reacti...

Embodiment 2

[0062] Example 2 Construction of nano drug delivery system MPB-EGCG / DOX@PCM

[0063] In this example, a nano drug delivery system MPB-EGCG / DOX@PCM is constructed, and the specific process is as follows:

[0064] 1. Synthesis of mesoporous Prussian blue nanoparticles (MPB NPs)

[0065] Weigh 3.0g PVP and dissolve in 40mL 0.01M HCl solution, then add 132mg K 3 [Fe(CN) 6 ] After stirring for 30min, it was transferred to a polytetrafluoroethylene reactor and placed in an oven at 80°C for 24h. Then take it out to room temperature (25°C) to cool, and centrifuge at 12000rpm for 30min to collect the blue precipitate; then wash with ethanol and water three times to remove unreacted raw materials, and centrifuge to obtain MPB NPs.

[0066] 2. Synthesis of EGCG-Fe NPs

[0067] Weigh 1.0g PVP and dissolve it in 10mL pure water, then add 0.2mL FeCl 3 solution (100 mg / mL); after stirring for 1 h, 1 mL of EGCG solution (3.36 mg / mL) was added dropwise to the above mixture and stirred for...

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Abstract

The invention discloses a nano drug delivery system and a preparation method and an application thereof, and the nano drug delivery system is obtained by taking mesoporous Prussian blue nanoparticles as a matrix, coupling the mesoporous Prussian blue nanoparticles with EGCG-Fe NPs, and adding a temperature-sensitive phase change material for modification. The nano drug delivery system prepared by the scheme of the invention is simple to prepare, uniform in particle size, good in near-infrared photothermal conversion efficiency, good in photothermal stability and excellent in biocompatibility, effectively improves the curative effect of anthracycline antitumor drugs, reduces the side effect of tumor treatment drugs, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a nano drug delivery system and its preparation method and application. Background technique [0002] Malignant tumors have become a serious threat to human life and health. Chemotherapy is one of the main means of treating cancer. As a widely used anticancer drug, anthracyclines are widely used in solid tumors such as breast cancer and liver cancer It plays an important role in the clinical treatment of hematological malignancies such as myeloma. [0003] Prussian blue (Prussian blue, PB), as a dye with a long history, has attracted great attention in the past 300 years since its accidental discovery by Berlin chemist Diesbach (Diesbach) in 1704. PB is considered to be the first synthetic metal-organic coordination polymer reported in the literature. The synthesis is simple and the raw materials are easy to obtain. The US Food and Drug Administration (FDA) has already app...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/10A61K47/58A61K47/52A61K47/69A61K31/353A61K31/704A61K41/00A61P35/00B82Y5/00B82Y40/00
CPCA61K9/1635A61K47/58A61K47/52A61K47/6933A61K47/6929A61K31/353A61K31/704A61K41/0052A61P35/00B82Y5/00B82Y40/00A61K2300/00Y02E60/14
Inventor 周小雁梁景兰吴城广薛巍顾珩廖兵
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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