Combined kit for predicting child asthmatic attack and application thereof

A technology for children's asthma and kits, applied in biological tests, measuring devices, material testing products, etc., can solve the problems of inconsistent risk factors, inability to accurately judge the degree of the patient's condition, and rare reports of clinical transformation applications, etc. The effect of diagnostic sensitivity and specificity
CN113533748APending Publication Date: 2021-10-22WUXI CHILDRENS HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUXI CHILDRENS HOSPITAL
Publication Date
2021-10-22

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Abstract

The invention discloses a combined kit for predicting asthmatic attack of children and application of the combined kit. Target protein is obtained by collecting peripheral blood in acute stage and remission stage of asthmatic children, TMT-TM labeled quantitative proteomics technology detection and bioinformatics analysis of differentially expressed protein, a library is established. Then quantitative analysis is carried out on the target protein through a PRM targeted proteomics technology, a plasma protein marker combination is obtained, peripheral serum of an asthma child patient is detected through an ELISA method to determine the clinical application value of the markers and the combination of the markers, and on this basis, the combined kit is used for detecting the plasma marker combination, the asthmatic attack is predicted through the detection result, and the prediction result has high diagnostic sensitivity and specificity and is expected to become a laboratory diagnostic index of the asthmatic attack.
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Description

Technical field

[0001] The invention belongs to the field of biomedical development, and more particularly to a combination kit for predicting asthma episode of children. Background technique

[0002] Asthma is a chronic airway disease, which is expressed as reversible gas flow occurs, difficult to breathe, wheezing, cough, varying degrees of airway inflammation and bronchial high reactivity. Although people have known asthma in hundreds of years ago, there is still no gold standard for asthma diagnosis.

[0003] Airway HyperResponsiveness, AHR) Test helps the diagnosis of symptoms, but AHR's role is limited: Although AHR detection can be used to exclude asthma, for non-asthma patients, Patients with sexual inflammation have high reactivity. There are 20% to 30% of adult asthma patients to excessive diagnosis.

[0004] Fiber bronchoscopy has been considered to be the most important means of diagnosis of asthma, although it can accurately invade the airway to detect, but the price...

Claims

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