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Composition for preventing or treating respiratory diseases caused by fine dust and comprising extract of wrinkled gianthyssop herb and licorice root as active ingredients

A technique for respiratory diseases and Agaricus radix extract, which is applied in the field of compositions for respiratory diseases, can solve the problems of no forced discharge, difficult discharge and the like, and achieve the effects of reducing cough, reducing inflammation, and inhibiting sputum production.

Active Publication Date: 2021-10-22
科丝美诗纽芝丽株式会社 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] If the fine dust flows in through the respiratory system, it is not easy to discharge, and there is no way to force it to be discharged. It is impossible to know exactly when and what kind of problems will occur due to this damage. Therefore, it is urgent to develop a method that can prevent, alleviate, treat or improve. Respiratory tract and lung damage caused by fine dust and a new therapeutic agent for the treatment of respiratory diseases caused by it

Method used

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  • Composition for preventing or treating respiratory diseases caused by fine dust and comprising extract of wrinkled gianthyssop herb and licorice root as active ingredients
  • Composition for preventing or treating respiratory diseases caused by fine dust and comprising extract of wrinkled gianthyssop herb and licorice root as active ingredients
  • Composition for preventing or treating respiratory diseases caused by fine dust and comprising extract of wrinkled gianthyssop herb and licorice root as active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of Huoxiang extract and licorice extract

[0052] 1-1: Preparation of Huoxiang extract (comparative example 1)

[0053] 100 g of dried Huoxiang was added into 1.5 L of 30% alcohol, and extracted at a temperature of 70° C. for 4 hours. The extracted sample was filtered under reduced pressure using Whatman No. 2 filter paper, and the filtered extract was concentrated and dried using a vacuum rotary concentrator to prepare the Patchouli extract.

[0054] 1-2: Preparation of licorice extract (comparative example 2)

[0055] Except having used 100 g of dried licorice, it carried out in the same manner as 1-1, and as a result, the licorice extract was prepared.

[0056] 1-3: Preparation of Huoxiang and Licorice Extract (weight ratio 1:1) (Experimental Example 1)

[0057] Except having used 50 g of dried patchouli and 50 g of dried licorice, it carried out in the same manner as 1-1, and as a result, the patchouli and licorice extract (r...

Embodiment 2

[0062] Example 2: Confirmation of the cough-reducing effect of the extracts of Huoxiang and Licorice

[0063] In the present invention, in order to confirm the cough-reducing efficacy of the extracts of Patchouli and Glycyrrhiza licorice, the degree of expression of the transient receptor potential vanillic acid subtype 1, which is known as a cough receptor, was confirmed.

[0064] First, in RPMI1640 medium containing 10% fetal bovine serum (FBS), 100 U / ml penicillin and 100 μg / ml streptomycin (streptomycin), at 37 ° C, 5% CO 2 MH-S cells were cultured as alveolar macrophages under the conditions of . Add cells to a 6-well culture plate to reach 5 x 10 5 cells / ml, a mixture prepared by dissolving 50 mg / ml of coal and 50 mg / ml of fly ash as components of fine dust in DMSO (CFA) After treatment at a concentration of 200 μg / ml, the reaction caused by the fine powder was induced for 1 hour, and the solution of dimethyl sulfoxide and fetal bovine serum mixed at a ratio of 1:1 w...

Embodiment 3

[0072] Example 3: Confirmation of the Pulmonary Inflammation Inhibitory Effect of Huoxiang and Licorice Compound Extract

[0073] In the present invention, the expression levels of CXCR1 and CXCR2 were confirmed in order to confirm whether the composite extract of Huoxiang and Glycyrrhizae inhibits lung inflammation.

[0074] First, in RPMI1640 medium containing 10% fetal bovine serum, 100 U / ml penicillin and 100 μg / ml streptomycin, at 37°C, 5% CO 2 MH-S cells were cultured as alveolar macrophages under the conditions of . Add cells to a 6-well culture plate to reach 5 x 10 5 cells / ml, after the mixture (CFA) prepared by dissolving 50mg / ml coal and 50mg / ml fly ash as a component of fine dust in DMSO was treated at a concentration of 200μg / ml, the induction After 1 hour of the reaction caused by the fine dust, the solution of mixing dimethyl sulfoxide and fetal calf serum at 1:1 was treated with the concentration of 60 μg / ml for each of the single Agastache extract prepared...

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Abstract

The present invention relates to a composition for preventing or treating respiratory diseases, comprising an extract of wrinkled gianthyssop herb and licorice root as active ingredients, and more particularly, to the composition for preventing or treating respiratory diseases caused by fine dust, which contains, as an active ingredient, an extract obtained by mixing wrinkled gianthyssop herb and licorice root at a weight ratio of 1: 1 to 6: 1. The Agastache rugosus and licorice extract of the present invention has the efficacy of reducing cough by inhibiting the activity of transient receptor potential vanillic acid subtype 1, reducing lung inflammation by inhibiting the activity of CXCR1 and CXCR2, reducing the proportion of GR-1+CD11b+ cells, and inhibiting sputum production by inhibiting mucoprotein 5AC. In particular, it is confirmed that a composite mixture of agastache rugosus and licorice maximizes efficacy at a specific mixing ratio, and thus it can be effectively used as the composition for preventing or treating respiratory diseases caused by fine dust.

Description

technical field [0001] The present invention relates to a composition for preventing or treating respiratory diseases comprising extracts of Patchouli and Glycyrrhiza as active ingredients, more specifically, relates to a composition comprising Patchouli and Glycyrrhiza in a weight ratio of 1:1 to 6:1 A composition for the prevention or treatment of respiratory diseases caused by fine dust, which uses the mixed extract as an active ingredient. Background technique [0002] Recently, with the development of industrial economy, respiratory diseases are rapidly increasing due to environmental pollution and changes in dietary life. The increase in mortality and morbidity caused by air pollution is one of the greatest risk factors threatening human health. According to the report of the World Health Organization, three million people die from air pollution every year (accounting for about 5% of all deaths) ), these effects on the human body are known to be mainly caused by fine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61P11/00A61P11/10A61P11/14A23L33/105A61K36/484
CPCA61K36/532A61K36/484A61P11/00A61P11/10A61P11/14A23L33/105A23V2002/00A61K2300/00A23V2200/314
Inventor 琹正淏金惠林金镇学崔水英
Owner 科丝美诗纽芝丽株式会社
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