Liquid feeding system for liquid chromatography
A liquid chromatograph and liquid delivery technology, applied in the field of liquid delivery systems, can solve problems such as adverse effects on analysis results, user losses, and confusion in mobile phase flow.
Active Publication Date: 2021-10-22
SHIMADZU SEISAKUSHO CO LTD
View PDF8 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
If pulsation occurs, the flow rate of the mobile phase will be disordered, which will adversely affect the analysis results and cause user losses
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0020] Hereinafter, an embodiment of the liquid delivery system of the present invention will be described with reference to the drawings.
[0021] like figure 1 As shown, the liquid chromatograph includes a liquid delivery system 2 , a sample injection part 4 , a separation column 6 , a detector 8 and a control device 10 .
[0022] The liquid delivery system 2 of the embodiment includes: a serial double-plunger liquid delivery mechanism 3, including two plunger pumps 12 (first plunger pumps) and plunger pumps 14 (second plunger pumps) connected in series. plug pump); and a pressure sensor 16, which is used to detect the liquid delivery pressure of the liquid delivery mechanism 3. A check valve 18 is provided at the inlet of the front plunger pump 12 , and a check valve 20 is provided between the outlet of the front plunger pump 12 and the inlet of the rear plunger pump 14 . The plunger pump 12 and the plunger pump 14 are configured to operate complementary to each other to ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
A liquid feeding system (2) for liquid chromatography is provided with a liquid feeding mechanism (3) configured to continuously feed a liquid by means of at least one plunger pump (12, 14) for feeding a liquid by reciprocating driving of a plunger; a pressure sensor (16) for detecting the pressure of a liquid being fed by the liquid feeding mechanism (3); and a liquid feeding failure detection unit (22) configured to cyclically obtain the pressure of the liquid being fed, detected by the pressure sensor (16) at a cycle enabling reading of a variation in one drive cycle of the liquid feeding mechanism (3), and detect failure in liquid feeding in the liquid feeding mechanism (3) by using the obtained pressure of the liquid being fed. The liquid feeding failure detection unit (22) is configured to execute, in order, a pulsation detection step for obtaining the variation range of the pressure of the liquid being fed within a prescribed drive cycle of the liquid feeding mechanism (3), and detecting pulsation on condition that the number of continuous occurrence of the cycles in which the variation range exceeds a prescribed reference value has exceeded a prescribed reference number; and a liquid feeding failure detection step for detecting failure in liquid feeding in the liquid feeding mechanism (3) when the pulsation has been detected in the pulsation detection step.
Description
technical field [0001] The invention relates to a liquid delivery system for continuously transporting mobile phase in a liquid chromatograph analysis system. Background technique [0002] A liquid delivery system for a liquid chromatograph is required to stably deliver a solvent used as a mobile phase at a set flow rate. As the liquid feeding mechanism of the liquid feeding system, a single plunger type including a single plunger pump and a double plunger type including two plunger pumps are used. [0003] When the plunger pump discharges the solvent, the compression of the solvent, the leakage of the check valve, the mixing of fine air bubbles into the flow path, the depletion of the solvent, etc. cause the pressure of the liquid to be lowered, thereby causing a so-called pulsation. When the hydraulic pressure fluctuates greatly periodically. If pulsation occurs, the flow rate of the mobile phase will be disturbed, which will adversely affect the analysis results and cau...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/32
CPCG01N30/32G01N30/8658G01N2030/027
Inventor 五味朋寛北林大介今村信也小川佳祐日光政隆军司昌秀
Owner SHIMADZU SEISAKUSHO CO LTD