A cervical cancer prognosis scoring system and its application
A technology for seeding cervix and cervical cancer, applied in the field of cervical cancer prognostic scoring system, can solve problems such as insufficient objectivity and uniformity, controversy, insufficient treatment, etc.
Active Publication Date: 2022-05-20
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology
Although clinicopathological staging has certain guiding significance for judging prognosis, there are still some controversies.
The criteria for interpretation of pathological factors (such as LVSI, depth of stromal invasion) are not objective and uniform enough, leading to overtreatment or undertreatment of some patients
Method used
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[0059] 1. Research object
[0060] The research objects of this implementation case are postoperative tumor tissue samples of patients with FIGO I-II and IIIC cervical cancer. Inclusion criteria: clear pathological diagnosis of cervical cancer squamous cell carcinoma, adenosquamous cell carcinoma or common adenocarcinoma; complete pathological sections and paraffin specimens; follow-up time of at least 3 months; complete clinical data.
[0061] Exclusion criteria: FIGO IIIA, IIIB and IV stages; preoperative neoadjuvant chemotherapy; preoperative radiation therapy; combined with ovarian cancer, cervical cancer and other gynecological malignancies; other pathological types, such as mucinous adenocarcinoma, clear cell carcinoma, small cell carcinoma Carcinoma; missing pathological sections or paraffin specimens; no follow-up time less than 3 months.
[0062] 2. Research methods
[0063] 2.1 Collection of clinical data
[0064] By consulting the patient's inpatient medical reco...
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Abstract
The invention provides a reagent and a prognosis scoring system for judging the postoperative recurrence risk of cervical cancer patients. FIGO (2018) After radical surgery, patients with stage I–II and IIIC cervical cancer were staged and assigned risk scores according to clinical physical examination and pathological examination; The expression of PD-L1, VISTA, and B7-H4 was detected chemically, and a risk score was assigned. The sum of the above two scores is the recurrence risk or prognosis score. According to this scoring system, cervical cancer patients are stratified into low-risk, intermediate-risk and high-risk. This prognostic scoring system has a higher ability to judge recurrence than the existing FIGO staging and helps to avoid overtreatment and undertreatment.
Description
technical field [0001] The invention relates to the field of biomedicine, in particular to a cervical cancer prognosis scoring system and its application. Background technique [0002] Cervical cancer is the most common gynecological malignancy in my country. For patients with early-stage cervical cancer, surgical treatment is the main treatment method, and for patients with high-risk factors after surgery, adjuvant chemotherapy and radiotherapy should be accepted. At present, the choice of treatment for cervical cancer is mainly based on clinical stage and postoperative pathological factors (such as tumor size, depth of tumor invasion, LVSI of vascular tumor thrombus, parametrial invasion, surgical margin status, and lymph node metastasis). In 2018, FIGO, the International Federation of Obstetrics and Gynecology, revised the staging of cervical cancer, changing the original clinical staging to clinicopathological staging, and incorporating imaging examination and pathologi...
Claims
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IPC IPC(8): G01N33/574G01N33/68A61B5/00
CPCG01N33/57442G01N33/57484G01N33/6893G01N33/6872A61B5/41G01N2333/70532
Inventor 向阳宗丽菊杨隽钧曹冬焱陈杰于双妮孔雨佳周云灿
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI