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A kind of preparation method and application of the composition containing nmn

A composition and water-soluble polymer technology, which can be applied in the directions of medical preparations containing active ingredients, drug combinations, and non-active ingredients medical preparations, etc., can solve problems such as NMN decomposition, and achieve improved utilization and efficacy. , to maintain the efficacy of the drug

Active Publication Date: 2022-04-22
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above problems, the present invention provides a preparation method and application of a composition containing NMN. By combining the preparation stage of NMN with the preparation stage of capsules, the method effectively simplifies the preparation process of NMN capsules, and alleviates the NMN easily affected by the outside world. Factors affecting the problem of decomposition

Method used

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  • A kind of preparation method and application of the composition containing nmn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a composition containing NMN, comprising the steps of:

[0028] (1) Mix the NMN aqueous solution purified after preparation by microbial fermentation with the extractant (ethanol) in a ratio of 1:10 by volume, then stir for 30 minutes, leave the resulting mixture for 30 minutes, and separate the liquid after layering Add it into a separatory funnel to separate the oily liquid, which is an oily mixture of NMN and water, and then extract the oily liquid twice with the above-mentioned extractant to obtain an oily liquid containing NMN for future use.

[0029] (2) Mix the oily liquid finally obtained in step (1) with monoglycerides and phospholipids in a mass ratio of 25:35:20, stir evenly, and then granulate in a granulator to obtain NMN-containing lipids quality particles, spare. Wherein, the monoglyceride of fatty acid is glycerol monooleate, and the phospholipid is soybean phospholipid.

[0030] (3) Add the NMN-containing lipid particles obtain...

Embodiment 2

[0032] A preparation method of a composition containing NMN, comprising the steps of:

[0033] (1) Mix the NMN aqueous solution purified after preparation by microbial fermentation with the extractant (ethanol) at a ratio of 1:8 by volume, then stir for 30 minutes, leave the resulting mixture for 30 minutes, and separate the liquid after layering Add it into a separatory funnel to separate the oily liquid, which is an oily mixture of NMN and water, and then extract the oily liquid twice with the above-mentioned extractant to obtain an oily liquid containing NMN for future use.

[0034] (2) Mix the oily liquid finally obtained in step (1) with monoglycerides and phospholipids according to the mass ratio of 20:30:15, stir evenly, and then granulate in a granulator to obtain NMN-containing lipids quality particles, spare. Wherein, the monoglyceride of fatty acid is glyceryl monostearate, and the phospholipid is sunflower phospholipid.

[0035] (3) Add the NMN-containing lipid p...

Embodiment 3

[0037] A preparation method of a composition containing NMN, comprising the steps of:

[0038] (1) Mix the NMN aqueous solution purified after preparation by microbial fermentation with the extractant (isopropanol) in a ratio of 1:12 by volume, then stir for 30 minutes, and leave the obtained mixture for 35 minutes, and wait for the layering Add the liquid into the separatory funnel to separate the oily liquid, which is the oily mixture formed by NMN and water, and then extract the oily liquid once more with the above-mentioned extractant to obtain the oily liquid containing NMN for later use.

[0039] (2) Mix the oily liquid finally obtained in step (1) with monoglycerides and phospholipids in a mass ratio of 45:40:30, stir evenly, and then granulate in a granulator to obtain NMN-containing lipids quality particles, spare. Wherein, the monoglyceride of fatty acid is glycerol monolaurate, and the phospholipid is yellow lecithin.

[0040](3) Add the NMN-containing lipid parti...

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Abstract

The present invention relates to the technical field of NMN preparation, in particular to a preparation method and application of a NMN-containing composition. The method comprises: (1) mixing the NMN aqueous solution obtained after being prepared by microbial fermentation with an extractant, and standing for separation After layering, take off the oily liquid containing NMN of the layer, and set aside. (2) Mix the oily liquid with monoglycerides and phospholipids evenly, and then granulate to obtain lipid granules containing NMN, which are set aside. (3) adding the NMN-containing lipid particles into the enteric coating solution containing bone powder for coating, and drying after completion to obtain the NMN-containing composition. The method of the invention integrates the preparation stage of NMN and the preparation stage of capsules, effectively simplifies the preparation process of NMN capsules, and alleviates the problem that NMN is easily decomposed by external factors.

Description

technical field [0001] The invention relates to the technical field of NMN preparation, in particular to a preparation method and application of a composition containing NMN. Background technique [0002] NMN, β-nicotinamide mononucleotide, is a naturally occurring biologically active nucleotide. NMN has two different forms, α and β, and the β isomer is the active form of NMN. NMN is widely distributed in daily food, such as vegetables, fruits, meat, etc. are rich in NMN, and the human body will continue to synthesize NMN. Modern scientific research shows that: NMN plays an important role in the energy generation of human cells. It participates in the synthesis of NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion) in cells. Nicotinamide mononucleotide W+NMN It can increase NAD in organs, thereby inhibiting the aging of nerves and blood vessels, and can also improve the symptoms of diabetes. However, with age, the body's ability to syn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/706A61K9/50A61K47/46A61K47/14A61K47/24A61P3/02A61P3/14
CPCA61K31/706A61K9/5073A61K9/5015A61K9/5063A61P3/02A61P3/14
Inventor 卢伟尹训娟刘长峰水清洋潘庆晓张建华
Owner SHANDONG RUNDE BIOTECH CO LTD
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