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Application of sulforaphane in preparation of drug for inhibiting and/or treating radioactive muscle fibrosis

A technology of sulforaphane and radioactivity, applied in the field of biomedicine, can solve the problems of delay, interruption of radiotherapy, affecting the treatment effect and overall survival of patients, and achieve the effect of reducing excessive accumulation and improving muscle fibrosis

Inactive Publication Date: 2021-11-30
JILIN UNIV
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Problems solved by technology

However, long-term radiotherapy toxicity to normal tissues is still unavoidable, among which radiation muscle fibrosis (RIMF) is one of the common serious long-term complications caused by radiotherapy, which not only seriously affects the appearance and quality of life of patients, but also leads to the interruption of radiotherapy and delay, and even affect the treatment effect and overall survival of patients
At present, there are no anti-fibrotic drugs clinically approved for the prevention and reversal of radioactive myofibrosis. The treatment strategy is only symptomatic and supportive treatment, such as the use of steroid hormone ointments such as mometasone furoate and betamethasone, and creams such as Biafine. But the effect is not ideal, only play a certain degree of prevention and treatment, it is difficult to meet the needs of clinical patients

Method used

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  • Application of sulforaphane in preparation of drug for inhibiting and/or treating radioactive muscle fibrosis
  • Application of sulforaphane in preparation of drug for inhibiting and/or treating radioactive muscle fibrosis
  • Application of sulforaphane in preparation of drug for inhibiting and/or treating radioactive muscle fibrosis

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Experimental program
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Effect test

Embodiment 1

[0033] Group animals:

[0034] Constructing an animal model: An animal model of radioactive muscle fibrosis was established by using an X-RAD 320 X-ray irradiator to irradiate the skeletal muscle of the left thigh of the mouse once.

[0035] (1) Blank control group (CON): no radiation treatment, subcutaneous injection of the corresponding dose of normal saline for 5 consecutive days a week, continuous injection for 4 weeks, observation until the 8th week;

[0036] (2) SFN group (SFN): no radiation treatment, and the IR / SFN group received subcutaneous injection of SFN (0.5mg / kg) simultaneously, continuous injection for 4 weeks, observation until the 8th week;

[0037] (3) Irradiation group (IR): The skeletal muscle of the left thigh of the mouse received a single 40Gy ray irradiation, and on the day of irradiation, the same dose of SFN preparation solvent (normal saline) was given, continuously injected for 5 days a week for 4 weeks, Observation until the 8th week;

[0038] (...

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Abstract

The invention provides application of sulforaphane in preparation of a drug for inhibiting and / or treating radioactive muscle fibrosis, and relates to the technical field of biological medicines. The Sulforaphane (SFN) serves as an Nrf2 agonist, can play a role in inhibiting tumors by intervening signal transduction pathways related to oxidative stress, inflammation, cell cycle, proliferation, apoptosis, angiogenesis, metastasis and the like, and can protect various tissues and organs from fibrosis. The SFN can inhibit expression of fibrosis genes by regulating Nrf2-mediated oxidative stress and TGF-beta1 / Smad signal pathways, excessive accumulation of extracellular matrix (ECM) is reduced, and therefore muscle fibrosis caused by radiation is remarkably improved, and the application has certain significance in clinical application in the future.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of sulforaphane in the preparation of drugs for inhibiting and / or treating radioactive muscle fibrosis. Background technique [0002] Radiotherapy not only kills tumor cells through ion-irradiation (IR), but also causes varying degrees of damage to normal tissues within the target area. However, long-term radiotherapy toxicity to normal tissues is still unavoidable, among which radiation muscle fibrosis (RIMF) is one of the common serious long-term complications caused by radiotherapy, which not only seriously affects the appearance and quality of life of patients, but also leads to the interruption of radiotherapy And delay, and even affect the treatment effect and overall survival of patients. At present, there are no anti-fibrotic drugs clinically approved for the prevention and reversal of radioactive myofibrosis. The treatment strategy is only...

Claims

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Application Information

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IPC IPC(8): A61K31/26A61P21/00A61P35/00
CPCA61K31/26A61P21/00A61P35/00
Inventor 姜新辛颖杨格王斌赵钦魏金龙王欢欢
Owner JILIN UNIV
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