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Anti-hair loss and hair growth integrated core-shell microneedle patch and preparation method thereof

A technology of anti-hair loss and hair growth and microneedle sticking, which is applied in the direction of sheet delivery, medical formula, and medical preparations of non-active ingredients, etc., can solve the problems of severe hair loss and difficulty in hair growth, and achieve the promotion of hair follicle growth, low price, and method simple effect

Pending Publication Date: 2021-11-30
TANGYI HLDG(SHENZHEN) LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an integrated core-shell microneedle patch for anti-hair loss and hair growth and its preparation method, so as to solve the above-mentioned problems of severe hair loss and difficulty in hair growth in humans

Method used

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  • Anti-hair loss and hair growth integrated core-shell microneedle patch and preparation method thereof
  • Anti-hair loss and hair growth integrated core-shell microneedle patch and preparation method thereof
  • Anti-hair loss and hair growth integrated core-shell microneedle patch and preparation method thereof

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Embodiment 1

[0037] A method for preparing an anti-hair loss integrated core-shell microneedle patch, comprising the following steps,

[0038] (1) Preparation of the microneedle shell structure: dissolving the nanozyme in the aqueous solution of the shell matrix material to form a mixture, centrifuging the mixture to remove air and depositing it on a polydimethylsiloxane (PDMS) microneedle negative mold, and then The PDMS microneedle negative mold is centrifuged to make the mixture flow into the forming hole of the microneedle negative mold, and the microneedle positive mold matched with the PDMS microneedle negative mold is pressed into the microneedle negative mold and placed in a desiccator at room temperature Keep for 2 hours, the shell matrix material adopts polyvinyl alcohol;

[0039] (2) Preparation of microneedle nucleus structure: Human bone marrow mesenchymal stem cells were cultured, and exosomes derived from mesenchymal stem cells were isolated from the cell culture medium usin...

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Abstract

The invention discloses an anti-hair loss and hair growth integrated core-shell microneedle patch and a preparation method thereof. The anti-hair loss and hair growth integrated core-shell microneedle patch comprises a backing and a core-shell microneedle array attached to one side of the backing, the core-shell microneedle array comprises a plurality of microneedles arranged on the backing in an array mode, each microneedle comprises a shell matrix material and an inner core, the shell matrix material is loaded with a nano-enzyme for removing excessive active oxygen. According to the anti-hair loss and hair growth integrated core-shell microneedle patch and the preparation method thereof, the shell matrix material is rapidly degraded after the microneedle patch is applied to the skin, and the loaded nano-enzyme can passively release and remove active oxygen and promote the generation of blood vessels in the microenvironment around hair follicles, exosome derived from mesenchymal stem cells is loaded in the inner core of the microneedle, and the inner exosome is released and conveyed to a hair follicle ecological niche after the shell matrix material is degraded, so that the pigmentation can be improved, and the hair regeneration is promoted.

Description

technical field [0001] The invention relates to the technical field of microneedle patches, in particular to a core-shell microneedle patch for preventing hair loss and hair growth and a preparation method thereof. Background technique [0002] Hair loss is a common ailment in humans due to a variety of reasons including aging, disease, and medications. It is estimated that more than 50% of the general population suffers from alopecia. The current clinical treatment of alopecia mainly relies on hair follicle transplantation, but it is limited by high surgical costs, invasiveness, and shortage of donors. In contrast, non-invasive, inducing intrinsic hair follicle regeneration is one of the effective methods to address hair loss. [0003] Typically, human hair follicles undergo a cycle of quiescence, regeneration, and degeneration regulated by hair follicle stem cells, which can be activated by signals primarily from their niche and enter the telogen-anagen transition from ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/43A61K9/70A61K47/32A61P17/14
CPCA61K38/43A61K9/7023A61K47/32A61P17/14A61M37/0015A61M2037/0046A61M2037/0023A61K9/0021B29K2883/00B29L2031/7544B29L2031/756B29K2029/04B29C41/04B29C41/38A61K35/28C12N5/0663B29C43/021B29C43/003B29C2043/025A61M2037/0053
Inventor 郑斌曹毓琳李博文孙维程世翔
Owner TANGYI HLDG(SHENZHEN) LTD
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