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Laetiporus cinnabarinus and application thereof

A technology of sulfur bacteria and vermilion, applied in the field of microorganisms, can solve problems such as abnormal liver function, blood lipid disorder, hospitalization or death of patients, and achieve a quick effect

Active Publication Date: 2021-11-30
孙长春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently, patients receiving IL-6 or TNF-α antibody therapy have an increased risk of infection, abnormal liver function, and dyslipidemia, which can lead to hospitalization or death in severe cases

Method used

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  • Laetiporus cinnabarinus and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Preservation information of Laetiporus sulphureus ttys-997

[0027] The Laetiporus sulphureus ttys-997 of the present invention has been preserved in the General Microbiology Center of the China Microbiological Culture Collection Management Committee on December 3, 2020. The preservation address is: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing , and the deposit number is CGMCC No.21084.

Embodiment 2

[0028] Example 2, Isolation, identification and cultivation of Laetiporus sulphureus ttys-997

[0029]The fruiting body of the bacterial strain is obtained by picking from the stump, and a piece of the fruiting body is taken, placed on a PDA plate after aseptic treatment, and cultured at 28 degrees, and filamentous mycelium grows after 14 days. Take part of the filamentous mycelium and place it in a liquid medium for 28 days on a shaking table, and a large number of red granules are formed. The red particles were centrifuged and collected for genetic analysis and identification. The strain had a 18S rDNA-ITS fragment (as shown in SEQ ID NO: 1), and the sequence length was 578bp. After gene comparison, combined with the appearance of fruiting bodies, the The strain was identified as Laetiporus (Sulfur bacteria), as Laetiporus sulfureus (Sulfur bacteria vermilion). Its taxa are Eukaryota; Fungi; Dikarya; Basidionmycota; Agaricomycotina; Agaricomycetes; Polyporales; Laetiporus. ...

Embodiment 3

[0031] Embodiment 3, the effect of bacterial strain on inflammation model mouse serum IL-6 and TNF-α content

[0032] 1. Animal model: Rats were used as animal models, and 5% dextran sulfate sodium was administered intragastrically to establish a colitis model.

[0033] 2. Experimental animals: SD rats, male 180-220g. (Rearing environment: 22±2°C, humidity 45-65%, 12 hours day and night); free to eat and drink.

[0034] 3. Experimental method:

[0035] 1) Modeling: Raised in single cages. Except for the blank group, the other 5 groups were continuously administered with 5% dextran sulfate sodium (0.75g / kg) for 10 days, once a day, and the blank group was given the same amount of normal saline.

[0036] 2) Grouping and administration:

[0037] Rats were randomly divided into blank group, model group, experimental low-, medium-, and high-dose groups (adding 1mL / 100g, 2mL / 100g, and 4mL / 100g of Laetiporus sulphureus ttys-997, respectively), intestinal Raw 0.15g / kg, 10 in each ...

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Abstract

The invention relates to the technical field of microorganisms, in particular to laetiporus cinnabarinus and application thereof. The strain provided by the invention has a 18S rDNA-ITS sequence which is at least 99% consistent with the sequence as shown in SEQ ID NO: 1. The strain provided by the invention can significantly reduce the level of interleukin 6 (IL-6) and tumor necrosis factor (TNF-alpha) so as to treat and prevent interleukin 6 (IL-6) and / or tumor necrosis factor (TNF-alpha) pathway abnormality related diseases, and has the advantages of fast effect, greenness, safety and reliability.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a sulfur fungus vermilion and its application. Background technique [0002] Sulfur bacteria vermilion, Chinese alias sulfur polypore vermilion variant, red sulfur fungus, cockscomb, etc., belongs to Basidiomycota (Basidiomycota), Agaricomycetes (Agaricomycetes), non-fold bacteria (Polyporales), sulfur bacteria ( Laetiporus), widely distributed in my country's Heilongjiang, Hebei, Sichuan, Tibet, Xinjiang, Taiwan and other regions, is a large rare fungus with both food and medicine. The fruiting bodies are edible when they are young and mature, delicious and nutritious, and become cheese-like when they are old, not suitable for eating, but can be used as medicine. It is warm in nature, sweet in taste, and has various effects such as improving human immunity, but because its specific mechanism is not clear, its therapeutic indications in modern diseases are not clear. [0003] I...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/07A61P29/00A61P37/02A61P35/00A61P3/00A61P17/06A61P1/00A61P19/02A61P27/02A23L33/10C12R1/645
CPCA61K36/07A61P29/00A61P37/02A61P35/00A61P3/00A61P17/06A61P1/00A61P19/02A61P27/02A23L33/10A23V2002/00A23V2200/308A23V2200/324A23V2200/30A23V2250/208Y02A50/30
Inventor 孙长春
Owner 孙长春
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