System for prognosis of small cell lung cancer patient and application thereof
A technology for small cell lung cancer, patients, applied in the field of biomedicine, can solve problems such as few studies
Active Publication Date: 2021-12-03
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology
Therefore, m6A is an important factor involved in the occurrence and development of tumors, but its regulatory mechanism and role in small cell lung cancer are few and far between.
Method used
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Embodiment 1
[0064] Example 1. Prognostic model of small cell lung cancer established based on m6A and model verification
[0065] Download the GSE40275 cohort from the GEO database (https: / / www.ncbi.nlm.nih.gov / geo / ) as an international cohort for constructing a small cell lung cancer prognostic marker model; download the GSE60052 cohort as a Shanghai cohort for the above Validation of the model; and the National Cancer Center collected formalin-fixed paraffin-embedded FFPE tissues from patients with small cell lung cancer as the NCC cohort for model validation. The clinical characteristics of all patients are shown in Table 1.
[0066] Table 1 Clinical characteristics of patients with lung cancer
[0067]
[0068] Note: NA means not available
[0069] In the NCC cohort, the inclusion criteria for patients with small cell lung cancer were as follows: 1) the patient was diagnosed as small cell lung cancer by the National Cancer Center; 2) the patient’s diagnosis and treatment informat...
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Abstract
The invention discloses a system for prognosis of small cell lung cancer patients and an application thereof. The invention discloses the system for the prognosis of a small cell lung cancer patient. The system comprises a system and a data processing device, wherein the system is used for detecting expression quantities of eleven genes including PRRC2A, IGF2BP1, METTL5, METTL14, G3BP1, ZCCHC4, IGF2BP3, RBM15B, ALKBH5, YTHDC2 and IGF2BP2. Experiments prove that the system for the prognosis of the small cell lung cancer patient is a reliable prediction model for the prognosis of the small cell lung cancer patient, can be used for the prognosis of the small cell lung cancer patient, can become a clinically useful tool, and is beneficial to promoting the accurate prediction and individualized comprehensive treatment of the prognosis of the small cell lung cancer patient. The system for the prognosis of the small cell lung cancer patients and the application thereof has an important application value.
Description
technical field [0001] The invention relates to a system for prognosis of patients with small cell lung cancer and its application in the field of biomedicine. Background technique [0002] Small cell lung cancer (SCLC) is a high-grade neuroendocrine tumor with high lethality, accounting for about 15% of lung cancers, and the five-year survival rate is less than 7%. Despite the continuous development of new therapeutic measures such as molecularly targeted drugs and immune checkpoint inhibitors, there have been no significant breakthroughs in the treatment strategies for patients with small cell lung cancer in recent decades. Most small cell lung cancer patients rapidly develop drug resistance after treatment even though they are sensitive to chemotherapy. Moreover, the patient's condition progresses rapidly and is prone to metastasis, so the treatment options are limited. Therefore, there is an urgent clinical need to accurately screen suitable and beneficial small cell l...
Claims
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IPC IPC(8): C12Q1/6886C12N15/11C12Q1/6851G16B5/00G16B25/10G16B25/20G16H50/30
CPCC12Q1/6886C12Q1/6851G16B5/00G16B25/10G16B25/20G16H50/30C12Q2600/158C12Q2600/118C12Q2600/166C12Q2531/113C12Q2563/107C12Q2545/101C12Q2537/165
Inventor 赫捷孙楠张志慧张超奇张国超
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI