Improved porous implant loaded with Schwann cell-derived exosome

Abstract

The invention discloses an exosome-loaded improved porous implant suitable for oral implantation. The implant comprises a compact layer, a porous layer and a functional layer. The inner core is a compact layer, the outer layer of the compact layer of the inner core is a communicating porous layer, bone tissue growth is facilitated, and a support is provided for the functional layer; the outer layer of the porous layer is provided with threads, and the upper section of the porous layer is provided with Morse taper connection, so that micro gaps at the joint of the implant and an abutment can be reduced, the stability of the implant is improved, and bone resorption is effectively reduced; and pores of the porous layer are filled with the functional layer, the functional layer contains a gelatin compound loaded with a Schwann cell-derived exosome, and the exosome-gelatin compound can uniformly release the Schwann cell-derived exosome to surrounding bone tissues and has the functions of repairing damaged nerves, regulating tissue inflammation and promoting bone regeneration. The implant has the effects of repairing injured nerves, regulating tissue inflammation and promoting bone regeneration, effectively solves the problem of bone resorption after implantation, and can improve the stability at the initial stage of implantation to a certain extent.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an improved porous implant loaded with Schwann cell-derived exosomes. Background technique [0002] Oral implant treatment is the restoration of missing teeth through implant materials. At present, the commonly used clinical implant materials are titanium and titanium alloy materials, which have the advantages of light weight, relatively low elastic modulus, strong shock absorption capacity, high hardness, and excellent corrosion resistance. However, there are still the following problems in the application of titanium and titanium alloy materials: 1. Titanium and titanium alloy materials are biologically inert materials, and it is difficult to establish a connection with the surrounding tissue to form a whole. Generally, it takes 3-6 months to achieve osseointegration. long. 2. The elastic modulus of titanium is much higher than that of the surrounding bone tissue, and...

AI Technical Summary

Problems solved by technology

However, there are still the following problems in the application of titanium and titanium alloy materials: 1. Titanium and titanium alloy materials are biologically inert materials, and it is difficult to establish a connection with the surrounding tissue to form a whole. Generally, it takes 3-6 months to achieve osseointegration. long

2. The elastic modulus of titanium is much higher than that of the surrounding bone tissue, and it is easy to produce stress shielding effect around the implant, resulting in bone resorption and bone atrophy around the implant, and finally causes the loosening and falling off of the implant

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